Skip to main content
SpringerLink
Log in

Polymorphism of the adrenergic receptor alpha 2a −1291C>G genetic variation and clozapine-induced weight gain

  • Published:
Journal of Neural Transmission Aims and scope Submit manuscript

Summary.

Weight gain, leading to further morbidity and poor treatment compliance, is a common consequence of treatment with clozapine. The substantial interindividual and interracial differences in drug-induced weight gain suggest that genetic factors may be important. Several studies showed that alpha-2, adrenoceptor may related to feeding behavior with rat or lipolytic activity of human adipocyte tissue, they are related to body weight change. In the study, we try to test the possible relation of clozapine-induced weight gain and adrenergic receptor alpha 2a −1291C>G genetic polymorphism in a long term follow up (14.0 ± 6.2 months). Our results show the genotype GG (8.45 ± 7.2 Kg) with higher mean body weight gain than genotype CC (2.79 ± 6.1 Kg) (p = 0.023). The finding identify a genetic factor associated with clozapine-induced weight gain in schizophrenic patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • DB Allison JL Mentore M Heo LP Chandler JC Cappelleri MC Infante PJ Weiden (1999) ArticleTitleAntipsychotic-induced weight gain: a comprehensive research synthesis. Am J Psychiatry 156 1686–1696 Occurrence Handle10553730

    PubMed  Google Scholar 

  • DB Allison JA Mackell DD McDonnell (2003) ArticleTitleThe impact of weight gain on quality of life among persons with schizophrenia. Psychiatr Serv 54 565–567 Occurrence Handle10.1176/appi.ps.54.4.565 Occurrence Handle12663847

    Article  PubMed  Google Scholar 

  • YM Bai CC Lin JY Chen CY Lin (1999) ArticleTitleWeight gain among patients on clozapine. Psychiatr Serv 50 704–705 Occurrence Handle10332914

    PubMed  Google Scholar 

  • DB Bylund (1988) ArticleTitleSubtypes of alpha 2-adrenoceptors: pharmacological and molecular biological evidence converge. Trends Pharmacol Sci 9 356–361 Occurrence Handle10.1016/0165-6147(88)90254-4 Occurrence Handle2855960

    Article  PubMed  Google Scholar 

  • DE Casey SH Zorn (2001) ArticleTitleThe pharmacology of weight gain with antipsychotics. J Clin Psychiatry 62 IssueID[Suppl 7] 4–10

    Google Scholar 

  • SW Coppack MD Jensen JM Miles (1994) ArticleTitleIn vivo regulation of lipolysis in humans. J Lipid Res 35 177–193 Occurrence Handle8169522

    PubMed  Google Scholar 

  • GS Etchegoyen H Del Zotto JJ Gagliardino (1997) ArticleTitleEffect of prolonged feeding of a sucrose-rich diet to normal rats on their hypothalamic alpha-2 adrenergic receptors. Horm Metab Res 29 84–85 Occurrence Handle9105906

    PubMed  Google Scholar 

  • C Garenc L Perusse YC Chagnon T Rankinen J Gagnon IB Borecki AS Leon JS Skinner JH Wilmore DC Rao C Bouchard (2002) ArticleTitleThe alpha 2-adrenergic receptor gene and body fat content and distribution: the HERITAGE Family Study. Mol Med 8 88–94 Occurrence Handle12080184

    PubMed  Google Scholar 

  • L Hellstrom S Reynisdottir D Langin S Rossner P Arner (1996) ArticleTitleRegulation of lipolysis in fat cells of obese women during long-term hypocaloric diet. Int J Obes Relat Metab Disord 20 745–752 Occurrence Handle8856398

    PubMed  Google Scholar 

  • L Hellstrom S Rossner E Hagstrom-Toft S Reynisdottir (1997) ArticleTitleLipolytic catecholamine resistance linked to alpha 2-adrenoceptor sensitivity – a metabolic predictor of weight loss in obese subjects. Int J Obes Relat Metab Disord 21 314–320 Occurrence Handle10.1038/sj.ijo.0800407 Occurrence Handle9130030

    Article  PubMed  Google Scholar 

  • CJ Hong CH Lin YW Yu SC Chang SY Wang SJ Tsai (2002) ArticleTitleGenetic variant of the histamine-1 receptor (glu349asp) and body weight change during clozapine treatment. Psychiatr Genet 12 169–171 Occurrence Handle10.1097/00041444-200209000-00009 Occurrence Handle12218662

    Article  PubMed  Google Scholar 

  • M Lafontan M Berlan (1993) ArticleTitleFat cell adrenergic receptors and the control of white and brown fat cell function. J Lipid Res 34 1057–1091 Occurrence Handle8371057

    PubMed  Google Scholar 

  • S Lario J Calls A Cases J Oriola A Torras F Rivera (1997) ArticleTitleMspI identifies a biallelic polymorphism in the promoter region of the alpha 2A-adrenergic receptor gene. Clin Genet 51 129–130 Occurrence Handle9112004

    PubMed  Google Scholar 

  • VJ Lawrence SW Coppack (2000) ArticleTitleThe endocrine function of the fat cell-regulation by the sympathetic nervous system. Horm Metab Res 32 453–467 Occurrence Handle11246810

    PubMed  Google Scholar 

  • BE Levin B Planas (1993) ArticleTitleDefective glucoregulation of brain alpha 2-adrenoceptors in obesity-prone rats. Am J Physiol 264 R305–R311 Occurrence Handle8095379

    PubMed  Google Scholar 

  • KA Liebzeit JS Markowitz CF Caley (2001) ArticleTitleNew onset diabetes and atypical antipsychotics. Eur Neuropsychopharmacol 11 25–32 Occurrence Handle10.1016/S0924-977X(00)00127-9 Occurrence Handle11226809

    Article  PubMed  Google Scholar 

  • GP Reynolds Z Zhang X Zang (2002) ArticleTitleAssociation of antipsychotic drug-induced weight gain with a 5-HT2C receptor gene polymorphism. Lancet 359 2086–2087 Occurrence Handle10.1016/S0140-6736(02)08913-4 Occurrence Handle12086765

    Article  PubMed  Google Scholar 

  • GP Reynolds Z Zhang X Zhang (2003) ArticleTitlePolymorphism of the promoter region of the serotonin 5-HT(2C) receptor gene and clozapine-induced weight gain. Am J Psychiatry 160 677–679 Occurrence Handle10.1176/appi.ajp.160.4.677 Occurrence Handle12668355

    Article  PubMed  Google Scholar 

  • R Rosmond C Bouchard P Bjorntorp (2002) ArticleTitleA C-1291G polymorphism in the alpha2A-adrenergic receptor gene (ADRA2A) promoter is associated with cortisol escape from dexamethasone and elevated glucose levels. J Intern Med 251 252–257 Occurrence Handle10.1046/j.1365-2796.2002.00961.x Occurrence Handle11886485

    Article  PubMed  Google Scholar 

  • DM Taylor R McAskill (2000) ArticleTitleAtypical antipsychotics and weight gain – a systematic review. Acta Psychiatr Scand 101 416–432 Occurrence Handle10.1034/j.1600-0447.2000.101006416.x Occurrence Handle10868465

    Article  PubMed  Google Scholar 

  • SJ Tsai CJ Hong YW Yu CH Lin (2002) ArticleTitle−759C/T genetic variation of 5HT(2C) receptor and clozapine-induced weight gain. Lancet 360 1790 Occurrence Handle10.1016/S0140-6736(02)11705-3

    Article  Google Scholar 

  • PJ Weiden JA Mackell DD McDonnell (2004) ArticleTitleObesity as a risk factor for antipsychotic noncompliance. Schizophr Res 66 51–57 Occurrence Handle10.1016/S0920-9964(02)00498-X Occurrence Handle14693352

    Article  PubMed  Google Scholar 

  • DA Wirshing JA Boyd LR Meng JS Ballon SR Marder WC Wirshing (2002) ArticleTitleThe effects of novel antipsychotics on glucose and lipid levels. J Clin Psychiatry 63 856–865 Occurrence Handle12416594

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Psychiatry, Yu-Li Veterans Hospital, Taipei, Taiwan, Republic of China

    Y.-C. Wang, Y.-M. Bai, J.-Y. Chen, C.-C. Lin, I.-C. Lai & Y.-J. Liou

  2. Institute of Medical Science, Tzu-Chi University, Hualien City, Taipei, Taiwan, Republic of China

    Y.-C. Wang

  3. Institute of Public Health, National Yang-Ming University, Taipei, Taiwan, Republic of China

    Y.-M. Bai

  4. Institute of Medical Science, College of Medicine, Taipei Medical University, Taipei, Taiwan, Republic of China

    C.-C. Lin

  5. Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China

    Y.-J. Liou

Authors
  1. Y.-C. Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Y.-M. Bai
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J.-Y. Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C.-C. Lin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. I.-C. Lai
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Y.-J. Liou
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wang, YC., Bai, YM., Chen, JY. et al. Polymorphism of the adrenergic receptor alpha 2a −1291C>G genetic variation and clozapine-induced weight gain. J Neural Transm 112, 1463–1468 (2005). https://doi.org/10.1007/s00702-005-0291-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00702-005-0291-7

Search

Navigation