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Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders

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Summary.

Two research groups have recently reported a significant association between schizophrenia and genetic variants of Frizzled-3 (FZD3) gene. We examined a possible association in a Japanese sample of schizophrenia, bipolar disorder, unipolar depression and controls with four single nucleotide polymorphisms (SNPs), tested in previous reports. We failed to find significant association in the four SNPs or haplotype analysis. The FZD3 gene might not play a role in conferring susceptibility to major psychosis in our sample.

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Authors and Affiliations

  1. Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan

    R. Hashimoto & H. Kunugi

  2. Department of Psychiatry, Fujita Health University School of Medicine, Aichi, Japan

    T. Suzuki, N. Iwata, Y. Yamanouchi & T. Kitajima

  3. Showa University Karasuyama Hospital, Tokyo, Japan

    A. Kosuga

  4. Department of Psychiatry, Showa University School of Medicine, Tokyo, Japan

    M. Tatsumi & K. Kamijima

  5. Yokohama Shinryo Clinic, Kanagawa, Japan

    M. Tatsumi

  6. Department of Psychiatry, Nagoya University Graduate School of Medicine, Aichi, Japan

    N. Ozaki

Authors
  1. R. Hashimoto
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  2. T. Suzuki
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  3. N. Iwata
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  4. Y. Yamanouchi
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  5. T. Kitajima
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  6. A. Kosuga
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  7. M. Tatsumi
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  8. N. Ozaki
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  9. K. Kamijima
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  10. H. Kunugi
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Hashimoto, R., Suzuki, T., Iwata, N. et al. Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders. J Neural Transm 112, 303–307 (2005). https://doi.org/10.1007/s00702-004-0264-2

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  • DOI: https://doi.org/10.1007/s00702-004-0264-2

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