Skip to main content
SpringerLink
Log in

Lack of association between two polymorphisms of brain-derived neurotrophic factor and response to typical neuroleptics

  • Published:
Journal of Neural Transmission Aims and scope Submit manuscript

Summary.

Several studies have connected brain-derived neurotrophic factor (BDNF) with treatment response to neuroleptics. In recent studies, the BDNF expression was reduced by typical neuroleptics. We conducted a retrospective study on 94 patients with schizophrenia and 98 controls. The BDNF G196A and C270T polymorphisms are not associated with treatment response to typical neuroleptics or with age at first hospitalization. Moreover, these polymorphisms of the BDNF gene are not associated with the risk of schizophrenia.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. University of Tampere, Medical School, Tampere, Finland

    S. Anttila, A. Illi, O. Kampman, K. M. Mattila, T. Lehtimäki & E. Leinonen

  2. Department of Psychiatry, Kanta-Häme Central Hospital, Hämeenlinna, Finland

    A. Illi

  3. Department of Psychiatry, Seinäjoki Hospital District, Seinäjoki, Finland

    O. Kampman

  4. Department of Clinical Chemistry, Laboratory of Atherosclerosis Genetics, Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland

    S. Anttila, K. M. Mattila & T. Lehtimäki

  5. Department of Psychiatry, Tampere University Hospital, Pitkäniemi, Finland

    E. Leinonen

Authors
  1. S. Anttila
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Illi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. O. Kampman
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K. M. Mattila
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. T. Lehtimäki
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. E. Leinonen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Anttila, S., Illi, A., Kampman, O. et al. Lack of association between two polymorphisms of brain-derived neurotrophic factor and response to typical neuroleptics. J Neural Transm 112, 885–890 (2005). https://doi.org/10.1007/s00702-004-0233-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00702-004-0233-9

Search

Navigation