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Association study of the dopamine and serotonin transporter genetic polymorphisms and methamphetamine abuse in Chinese males

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Summary.

The dopamine transporter (DAT) and the serotonin transporter (5-HTT) play important roles in methamphetamine (METH) dependence because they are the target of METH action. For this study, the association between the DAT and 5-HTT polymorphisms and METH dependence were investigated for a Chinese-male sample population. The investigated polymorphisms included those of the DAT 3′-variable number tandem repeat, the 5-HTT gene promoter and a 5-HTT variable number tandem repeat polymorphisms. No significant difference was demonstrated for genotype or allele frequency, when comparing METH dependent and control cases for the DAT and the 5-HTT polymorphisms. The findings of this study suggest that these polymorphisms do not play major roles in METH dependence in the Chinese-male population.

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Authors and Affiliations

  1.  Department of Psychiatry, Veterans General Hospital-Taipei, and, , , , , , TW

    C.-J. Hong, C.-Y. Cheng, L.-R. R. Shu, C.-Y. Yang & S.-J. Tsai

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  1. C.-J. Hong
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  2. C.-Y. Cheng
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  3. L.-R. R. Shu
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  4. C.-Y. Yang
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  5. S.-J. Tsai
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Additional information

Received January 8, 2002; accepted October 2, 2002 Published online December 9, 2002

RID="*"

ID="*"  The experiments in this study were performed in the Molecular Genetics Laboratory, Department of Psychiatry, Veterans General Hospital-Taipei, Taiwan, ROC

Acknowledgements This work was supported by Grant DOH89-TD-1095, provided by the Department of Health, Taiwan, ROC, and Grant VGH89-398-15, provided by the Veterans General Hospital-Taipei. The authors wish to thank Mr. C.-T. Feng, T.-H. Liu and the staff at the Taiwan Taipei Detention Center for their assistance with sample collection, and Ms S.-C. Chiang for her assistance in statistical analysis.

Authors' address: Dr. C.-J. Hong, Department of Psychiatry, Veterans General Hospital-Taipei, No. 201 Shih-Pai Road, Sec. 2, 11217, Taipei, Taiwan, Republic of China, e-mail: cjhong@vghtpe.gov.tw

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Hong, CJ., Cheng, CY., Shu, LR. et al. Association study of the dopamine and serotonin transporter genetic polymorphisms and methamphetamine abuse in Chinese males. J Neural Transm 110, 345–351 (2003). https://doi.org/10.1007/s00702-002-0790-8

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  • DOI: https://doi.org/10.1007/s00702-002-0790-8

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