Summary.
Cytochrome P450IIE1 (CYP2E1), an ethanol-inducible cytochrome P450 enzyme, is expressed in the basal ganglia and is probably involved in the activation of neurotoxicants, producing free radical metabolites and resulting in oxidative stress. To examine the association between CYP2E1 polymorphism and the risk of Parkinson's disease (PD), we performed a case-control study on a large population of Taiwanese PD patients, focusing especially on early-onset PD patients (onset at, or before, the age of 50). Two hundred and thirty-four PD patients and 251 age- and sex-matched controls were recruited. A much higher frequency of the uncommon c2 allele was seen in our control subjects than in Caucasians (0.23 vs. 0.02). There were no significant differences between PD patients and controls in the distribution of either allelic or genotype frequencies. Our results suggest that CYP2E1 is not a major or independent determinant in the occurrence of PD in Taiwanese.
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Received September 26, 2001; accepted February 7, 2002 Published online June 28, 2002
Acknowledgements This study was supported by research grants NSC 89-2314-B-002-143 and NSC 89-2314-002-566 from the National Science Council (Taipei, Taiwan, R.O.C.). The authors would like to thank Miss Y.-E. Lin for her clinical assistance and Dr. T. Barkas for revision of the English.
Authors' addresses: R. M. Wu, MD, PhD (correspondence and reprints), Department of Neurology, National Taiwan University Hospital, No 7, Chung-Shan South Road, Taipei 100, Taiwan, e-mail: rmwu@ha.mc.ntu.edu.tw; K. H. Chen, PhD (correspondence on statistic analyses and genetics), Institute of Epidemiology, College of Public Health, National Taiwan University, Room 1540, Basic Medicine Building, Section 1, 1 Jen-Ai Road, Taipei 100, Taiwan, e-mail: kuangho@ha.mc.ntu.edu.tw
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Wu, R., Cheng, C., Chen, K. et al. Genetic polymorphism of the CYP2E1 gene and susceptibility to Parkinson's disease in Taiwanese. J Neural Transm 109, 1403–1414 (2002). https://doi.org/10.1007/s00702-002-0721-8
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DOI: https://doi.org/10.1007/s00702-002-0721-8