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Neuropsychological and Quality of Life Changes Following Unilateral Thalamic Deep Brain Stimulation in Parkinson's Disease: A One-Year Follow-up

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Summary.

Background:

The long-term neuropsychological and quality of life (QOL) outcomes of unilateral thalamic deep brain stimulation (DBS) in patients with intractable Parkinson's disease (PD) have not heretofore been described.

Method:

Six patients diagnosed with PD underwent unilateral DBS implantation into a verified thalamic VIM nucleus target. Participants completed presurgical neuropsychological evaluation and follow-up assessment at approximately one year postsurgery.

Findings:

Compared to their presurgical scores, PD patients exhibited significant improvement on measures of conceptualization, verbal memory, emotional adjustment, and QOL at one-year follow-up. A few nominal declines were observed across the battery of tests.

Interpretation:

These data provide preliminary support for the long-term neurocognitive safety and QOL improvements following thalamic stimulation in patients with PD.

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Authors and Affiliations

  1. Department of Psychiatry & Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA, , , , , , US

    S. P. Woods & J. A. Fields

  2. Department of Neurology, University of Miami School of Medicine, Miami, Florida, USA, , , , , , US

    K. E. Lyons & W. C. Koller

  3. Division of Neurosurgery, University of Kansas Medical Center, Kansas City, Kansas, USA, , , , , , US

    S. B. Wilkinson

  4. Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA, , , , , , US

    R. Pahwa

  5. Departments of Psychiatry & Behavioral Sciences and of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington, USA, , , , , , US

    A. I. Tröster

Authors
  1. S. P. Woods
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  2. J. A. Fields
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  3. K. E. Lyons
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  4. W. C. Koller
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  5. S. B. Wilkinson
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  6. R. Pahwa
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  7. A. I. Tröster
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Woods, S., Fields, J., Lyons, K. et al. Neuropsychological and Quality of Life Changes Following Unilateral Thalamic Deep Brain Stimulation in Parkinson's Disease: A One-Year Follow-up. Acta Neurochir (Wien) 143, 1273–1278 (2001). https://doi.org/10.1007/s007010100024

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  • DOI: https://doi.org/10.1007/s007010100024

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