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Intracranial meningeal hemangiopericytoma: 10 years experience of a tertiary care Institute

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Abstract

Background

Intracranial meningeal hemangiopericytoma (HPC) represents a rare and aggressive intracranial neoplasm located along the dural sinuses. It constitutes less than 1 % of all intracranial tumors and approximately 2–4 % of all meningeal tumors. The authors present our institute’s experience in combined modality management of 15 successive patients of HPC.

Methods

We retrospectively reviewed 15 patients of HPC treated in our institute from 2001 to 2011. Clinical characteristics and treatment modality, in the form of surgery and radiotherapy, were noted. Statistical analysis was done with regards to recurrence free survival (RFS) and overall survival (OS) using Kaplan-Meier survival analysis.

Results

The median age of the patients was 40.0 years. Nine patients were males and six patients were females. The median duration of symptoms was six months. Headache was the most common presenting symptom followed by vomiting, motor weakness and seizures. Twelve patients underwent total excision while three had subtotal excision. Seven patients had WHO grade II histology tumors and eight patients had grade III histology. Thirteen patients received adjuvant radiotherapy (RT). Median RT dose delivered was 50 Gy. Five patients developed local recurrence. One patient had distant metastases. Median duration of RFS was 68 months.

Conclusions

HPCs are aggressive tumors. The mainstay of therapy is gross total resection at the initial surgery. Postoperative adjuvant RT should be offered to all patients, regardless of the degree of resection achieved. Long-term follow-up is important as local recurrences and distant metastases can develop years after the initial treatment.

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Conflicts of interest

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Authors and Affiliations

  1. Department of Radiotherapy and Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

    Narendra Kumar, Ritesh Kumar, Rakesh Kapoor, Sushmita Ghoshal, Pramod Kumar & Suresh Chander Sharma

  2. Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India

    Pravin S. Salunke

  3. Department of Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

    B. D. Radotra

  4. Department of Radiotherapy and Regional Cancer Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India

    Narendra Kumar

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  1. Narendra Kumar
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  2. Ritesh Kumar
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  3. Rakesh Kapoor
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  4. Sushmita Ghoshal
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  5. Pramod Kumar
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  6. Pravin S. Salunke
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  7. B. D. Radotra
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  8. Suresh Chander Sharma
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Corresponding author

Correspondence to Narendra Kumar.

Additional information

Comment

This is a concise and well-written report on a relevant neurosurgical topic. Although there is not much novel information in this paper, the Author’s experience is relatively large if one considers the rarity of the disease. It was important to report and discuss outcomes separately for grade II and III HPC.

Domenico d’Avella

Padova, Italy

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Kumar, N., Kumar, R., Kapoor, R. et al. Intracranial meningeal hemangiopericytoma: 10 years experience of a tertiary care Institute. Acta Neurochir 154, 1647–1651 (2012). https://doi.org/10.1007/s00701-012-1442-x

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  • DOI: https://doi.org/10.1007/s00701-012-1442-x

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