Abstract
Choroid plexus papillomas (CPP) are rare tumors of the central nervous system, usually occurring in the ventricular system. Apart from spinal drop metastases, CPPs are generally unique tumors. In this report, the authors present two exceptional adult cases involving multiple benign CPPs located in both intra- and extraventricular locations. The tumors were located in the fourth ventricle and Meckel's cave in one case and the cerebellopontine angle, the frontotemporal region and the fourth ventricle in the other. A review of the literature revealed that these two cases represent the first reported occurrences of multiple choroid plexus papillomas involving Meckel's cave and frontotemporal intraparenchymal locations.
References
Bonneville F, Savatovsky J, Chiras J (2007) Imaging of cerebellopontine angle lesions: an update. Part 2: intra-axial lesions, skull base lesions that may invade the CPA region, and non-enhancing extra-axial lesions. Eur Radiol 17:2908–2920
Casar Borota O, Jacobsen EA, Scheie D (2006) Bilateral atypical choroid plexus papillomas in cerebellopontine angles mimicking neurofibromatosis 2. Acta Neuropathol 111:500–502
Devadiga KV, Abraham J, Chandy J (1969) Primary choroid plexus papilloma of the cerebellopontine angle. Case report. J Neurosurg 30:286–288
Enomoto H, Mizuno M, Katsumata T, Doi T (1991) Intracranial metastasis of a choroid plexus papilloma originating in the cerebellopontine angle region: a case report. Surg Neurol 36:54–58
Fujimura M, Onuma T, Kameyama M, Motohashi O, Kon H, Yamamoto K, Ishii K, Tominaga T (2004) Hydrocephalus due to cerebrospinal fluid overproduction by bilateral choroid plexus papillomas. Childs Nerv Syst 20:485–488
Greene RC (1951) Extraventricular and intra-cerebellar papilloma of the choroid plexus. J Neuropathol Exp Neurol 10:204–207
Heese O, Lamszus K, Grzyska U, Westphal M (2002) Diffuse arachnoidal enhancement of a well differentiated choroid plexus papilloma. Acta Neurochir (Wien) 144:723–728
Irsutti M, Thorn-Kany M, Arrue P, Richaud J, Sol JC, Delisle MB, Manelfe C (2000) Suprasellar seeding of a benign choroid plexus papilloma of the fourth ventricle with local recurrence. Neuroradiology 42:657–661
Jeibmann A, Wrede B, Peters O, Wolff JE, Paulus W, Hasselblatt M (2007) Malignant progression in choroid plexus papillomas. J Neurosurg 107:199–202
Jinhu Y, Jianping D, Jun M, Hui S, Yepeng F (2007) Metastasis of a histologically benign choroid plexus papilloma: case report and review of the literature. J Neurooncol 83:47–52
Kaptanoglu E, Tun K, Celikmez RC, Ozen O, Taskin Y (2007) Spinal drop metastasis of choroid plexus papilloma. J Clin Neurosci 14:381–383
Karim A, Fowler M, McLaren B, Cardenas R, Patwardhan R, Nanda A (2006) Concomitant choroid plexus papillomas involving the third and fourth ventricles: A case report and review of the literature. Clin Neurol Neurosurg 108:586–589
Kim IY, Niranjan A, Kondziolka D, Flickinger JC, Lunsford LD (2008) Gamma knife radiosurgery for treatment resistant choroid plexus papillomas. J Neurooncol 90:105–110
Kimura M, Takayasu M, Suzuki Y, Negoro M, Nagasaka T, Nakashima N, Sugita K (1992) Primary choroid plexus papilloma located in the suprasellar region: case report. Neurosurgery 31:563–566
Krishnan S, Brown PD, Scheithauer BW, Ebersold MJ, Hammack JE, Buckner JC (2004) Choroid plexus papillomas: a single institutional experience. J Neurooncol 68:49–55
Leblanc R, Bekhor S, Melanson D, Carpenter S (1998) Diffuse craniospinal seeding from a benign fourth ventricle choroid plexus papilloma. Case report. J Neurosurg 88:757–760
Leys D, Pasquier F, Lejeune JP, Lesoin F, Petit H, Delandsheer JM (1986) Benign choroid plexus papilloma. 2 local recurrences and intraventricular seeding. Neurochirurgie 32:258–261
McCall T, Binning M, Blumenthal DT, Jensen RL (2006) Variations of disseminated choroid plexus papilloma: 2 case reports and a review of the literature. Surg Neurol 66:62–67, discussion 67–68
McEvoy AW, Galloway M, Revesz T, Kitchen ND (2002) Metastatic choroid plexus papilloma: a case report. J Neurooncol 56:241–246
McEvoy AW, Harding BN, Phipps KP, Ellison DW, Elsmore AJ, Thompson D, Harkness W, Hayward RD (2000) Management of choroid plexus tumours in children: 20 years experience at a single neurosurgical centre. Pediatr Neurosurg 32:192–199
McIver JI, Link MJ, Giannini C, Cohen-Gadol AA, Driscoll C (2003) Choroid plexus papilloma and meningioma: coincidental posterior fossa tumors: case report and review of the literature. Surg Neurol 60:360–365
Naguib MG, Chou SN, Mastri A (1981) Radiation therapy of a choroid plexus papilloma of the cerebellopontine angle with bone involvement. Case report. J Neurosurg 54:245–247
Okay O, Daglioglu E, Yakicier C, Uren D, Dalgic A, Ergungor F (2009) Choroid plexus papillomas in two siblings: case report. Turk Neurosurg 19:281–284
Pillai A, Rajeev K, Chandi S, Unnikrishnan M (2004) Intrinsic brainstem choroid plexus papilloma. Case report. J Neurosurg 100:1076–1078
Robinson RG (1955) Two cerebellar tumours with unusual features. 1. Cystic astrocytoma. 2. Papilloma of the chorid plexus. J Neurosurg 12:183–186
Sameshima T, Tanikawa R, Sugimura T, Izumi N, Seki T, Maeda T, Tsuboi T, Hashimoto M, Kimura T, Nabeshima K (2010) Choroid plexus papilloma originating in the sella turcica–case report. Neurol Med Chir (Tokyo) 50:144–146
Strojan P, Popovic M, Surlan K, Jereb B (2004) Choroid plexus tumors: a review of 28-year experience. Neoplasma 51:306–312
Tacconi L, Delfini R, Cantore G (1996) Choroid plexus papillomas: consideration of a surgical series of 33 cases. Acta Neurochir (Wien) 138:802–810
Taggard DA, Menezes AH (2000) Three choroid plexus papillomas in a patient with Aicardi syndrome. A case report. Pediatr Neurosurg 33:219–223
Talacchi A, De Micheli E, Lombardo C, Turazzi S, Bricolo A (1999) Choroid plexus papilloma of the cerebellopontine angle: a twelve patient series. Surg Neurol 51:621–629
Tasdemiroglu E, Awh MH, Walsh JW (1996) MRI of cerebellopontine angle choroid plexus papilloma. Neuroradiology 38:38–40
Uff CE, Galloway M, Bradford R (2007) Metastatic atypical choroid plexus papilloma: a case report. J Neurooncol 82:69–74
Wolburg H, Paulus W (2010) Choroid plexus: biology and pathology. Acta Neuropathol 119:75–88
Wolfson WL, Brown WJ (1977) Disseminated choroid plexus papilloma An ultrastructural study. Arch Pathol Lab Med 101:366–368
Yu H, Yao TL, Spooner J, Stumph JR, Hester R, Konrad PE (2006) Delayed occurrence of multiple spinal drop metastases from a posterior fossa choroid plexus papilloma. Case report. J Neurosurg Spine 4:494–496
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We would like to thank Dr. Michel Felce, Pathology Department, Beaujon Hospital, for her help in the pathological analysis of the cases.
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Matthieu Peyre and Alpha Bah contributed equally to this work.
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Peyre, M., Bah, A. & Kalamarides, M. Multifocal choroid plexus papillomas: case report. Acta Neurochir 154, 295–299 (2012). https://doi.org/10.1007/s00701-011-1172-5
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DOI: https://doi.org/10.1007/s00701-011-1172-5