Skip to main content

Advertisement

Log in

Urinary incontinence following deep brain stimulation of the pedunculopontine nucleus

  • Case Report
  • Published:
Acta Neurochirurgica Aims and scope Submit manuscript

Abstract

Low-frequency deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) has been reported to improve akinesia and gait difficulties in patients with Parkinson’s disease (PD). We report on a patient with PD and L-dopa refractory gait symptoms who developed detrusor over-activity immediately after right PPN DBS. Proximity between caudal PPN and brainstem structures implicated in control of micturition is a possible explanation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

References

  1. Barrington FJF (1925) The effect of lesions of the hind- and mid-brain on micturition in the cat. Q J Exp Physiol 15:81–102

    Google Scholar 

  2. Blok BF, Willemsen AT, Holstege G (1997) A PET study on brain control of micturition in humans. Brain 120(Pt 1):111–121

    Article  PubMed  Google Scholar 

  3. Ferraye MU, Debû B, Fraix V, Goetz L, Ardouin C, Yelnik J, Henry-Lagrange C, Seigneuret E, Piallat B, Krack P, Le Bas JF, Benabid AL, Chabardès S, Pollak P (2010) Effects of pedunculopontine nucleus area stimulation on gait disorders in Parkinson’s disease. Brain 133(Pt 1):205–214

    Article  PubMed  CAS  Google Scholar 

  4. Ferraye MU, Gerardin P, Debû B, Chabardès S, Fraix V, Seigneuret E, LeBas JF, Benabid AL, Tilikete C, Pollak P (2009) Pedunculopontine nucleus stimulation induces monocular oscillopsia. J Neurol Neurosurg Psychiatry 80(2):228–231

    Article  PubMed  CAS  Google Scholar 

  5. Fritsche HM, Ganzer R, Schlaier J, Wieland WF, Brawanski A, Lange M (2009) Acute urinary retention in two patients after subthalamic nucleus deep brain stimulation (STN-DBS) for the treatment of advanced Parkinson’s disease. Mov Disord 24:1553–1554

    Article  PubMed  Google Scholar 

  6. Garcia-Rill E, Houser CR, Skinner RD, Smith W, Woodward DJ (1987) Locomotion-inducing sites in the vicinity of the pedunculopontine nucleus. Brain Res Bull 18(6):731–738

    Article  PubMed  CAS  Google Scholar 

  7. Griffiths DHG, Dalm E, De Wall H (1990) Control and coordination of bladder and urethral function in the brainstem of the cat. Neurourol Urodyn 9:63–82

    Article  Google Scholar 

  8. Hirsch EC, Graybiel AM, Duyckaerts C, Javoy-Agid F (1987) Neuronal loss in the pedunculopontine tegmental nucleus in Parkinson disease and in progressive supranuclear palsy. Proc Natl Acad Sci USA 84(16):5976–5980

    Article  PubMed  CAS  Google Scholar 

  9. Jellinger K (1988) The pedunculopontine nucleus in Parkinson’s disease, progressive supranuclear palsy and Alzheimer’s disease. J Neurol Neurosurg Psychiatry 51(4):540–543

    Article  PubMed  CAS  Google Scholar 

  10. Mazzone P, Insola A, Sposato S, Scarnati E (2009) The deep brain stimulation of the pedunculopontine tegmental nucleus. Neuromodulation 12(3):191–204

    Article  Google Scholar 

  11. Moro E, Hamani C, Poon YY, Al-Khairallah T, Dostrovsky JO, Hutchison WD, Lozano AM (2010) Unilateral pedunculopontine stimulation improves falls in Parkinson’s disease. Brain 133(Pt 1):215–224

    Article  PubMed  Google Scholar 

  12. Nandi D, Jenkinson N, Stein J, Aziz T (2008) The pedunculopontine nucleus in Parkinson’s disease: primate studies. Br J Neurosurg 22(Suppl 1):S4–S8

    Article  PubMed  Google Scholar 

  13. Olsweski J, Baxter D (1982) Cytoarchitecture of the human brain stem. Karger, Switzerland

    Google Scholar 

  14. Plaha P, Gill SS (2005) Bilateral deep brain stimulation of the pedunculopontine nucleus for Parkinson’s disease. Neuroreport 16(17):1883–1887

    Article  PubMed  Google Scholar 

  15. Stefani A, Lozano AM, Peppe A, Stanzione P, Galati S, Tropepi D, Pierantozzi M, Brusa L, Scarnati E, Mazzone P (2007) Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson’s disease. Brain 130(Pt 6):1596–1607

    Article  PubMed  Google Scholar 

  16. Zrinzo L, Zrinzo LV, Tisch S, Limousin PD, Yousry TA, Afshar F, Hariz MI (2008) Stereotactic localization of the human pedunculopontine nucleus: atlas-based coordinates and validation of a magnetic resonance imaging protocol for direct localization. Brain 131(Pt 6):1588–1598

    Article  PubMed  Google Scholar 

  17. Zweig RM, Jankel WR, Hedreen JC, Mayeux R, Price DL (1989) The pedunculopontine nucleus in Parkinson’s disease. Ann Neurol 26(1):41–46

    Article  PubMed  CAS  Google Scholar 

  18. Zweig RM, Whitehouse PJ, Casanova MF, Walker LC, Jankel WR, Price DL (1987) Loss of pedunculopontine neurons in progressive supranuclear palsy. Ann Neurol 22(1):18–25

    Article  PubMed  CAS  Google Scholar 

Download references

Conflicts of interest

None.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Iciar Aviles-Olmos.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Aviles-Olmos, I., Foltynie, T., Panicker, J. et al. Urinary incontinence following deep brain stimulation of the pedunculopontine nucleus. Acta Neurochir 153, 2357–2360 (2011). https://doi.org/10.1007/s00701-011-1155-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00701-011-1155-6

Keywords

Navigation