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Leptomeningeal dissemination of a pediatric neoplasm with 1p19q deletion showing mixed immunohistochemical features of an oligodendroglioma and neurocytoma

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Abstract

Leptomeningeal dissemination of an oligodendroglioma is rarely reported in the neurosurgical literature, especially in cases with a classical 1p19q deletion. The authors describe a case wherein a 1p19q deletion in a disseminated tumor with mixed immunohistochemical features of oligodendroglioma and neurocytoma was encountered and treated. Stereotactic right frontal craniotomy was undertaken for obtaining definitive histological diagnosis. The results revealed a neuroectodermal neoplasm with histologic and immunohistochemical features of oligodendroglioma and neurocytoma. FISH analysis confirmed classical 1p19q deletion. The patient was treated postoperatively with chemotherapy and radiation therapy. He showed good clinical response and remains alive 16 months after diagnosis.

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Acknowledgements

Special thanks to Dr. Peter Burger (Johns Hopkins Univ.) and Dr. Paul McKeever (Univ. of Michigan—Ann Arbor) for serving as neuropathology experts in the review of histologic preparations.

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Authors and Affiliations

  1. Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, 48201, USA

    Richard B. Rhiew, Sunil Manjila & Murali Guthikonda

  2. Department of Neurosurgery, Medical College of Wisconsin & Froedtert Hospital, 9200 W. Wisconsin Avenue, Milwaukee, WI, 53226, USA

    Andrew Lozen

  3. Department of Pediatric Neurosurgery, Children’s Hospital of Michigan, Detroit, MI, 48201, USA

    Sandeep Sood

  4. Department of Pathology, Wayne State University School of Medicine, Detroit, MI, 48201, USA

    William J. Kupsky

Authors
  1. Richard B. Rhiew
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  2. Sunil Manjila
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  3. Andrew Lozen
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  4. Murali Guthikonda
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  5. Sandeep Sood
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  6. William J. Kupsky
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Correspondence to Andrew Lozen.

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Rhiew, R.B., Manjila, S., Lozen, A. et al. Leptomeningeal dissemination of a pediatric neoplasm with 1p19q deletion showing mixed immunohistochemical features of an oligodendroglioma and neurocytoma. Acta Neurochir 152, 1425–1429 (2010). https://doi.org/10.1007/s00701-010-0674-x

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  • DOI: https://doi.org/10.1007/s00701-010-0674-x

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