Skip to main content

Advertisement

SpringerLink
Log in

Epstein-Barr virus associated primary intracranial leiomyoma in organ transplant recipient: case report and review of the literature

  • Case Report
  • Published:
Acta Neurochirurgica Aims and scope Submit manuscript

    We’re sorry, something doesn't seem to be working properly.

    Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Abstract

Introduction

A 45 year old female renal transplant recipient presented with headaches of 3 months duration. Clinical and radiological evaluation revealed an approximately 4x4cm rounded, enhancing mass at the left temporal pole. At surgery, the mass had dural attachment and clinically, radiographically, and macroscopically resembled a meningioma. Histopathological analysis revealed a leiomyoma. Epstein-Barr virus (EBV) DNA was demonstrated within the tumour cell nuclei by the in situ hybridisation technique.

Discussion

This is the first documentation of an EBV-associated primary intracranial leiomyoma in an organ transplant recipient and provides additional evidence of a possible relation between EBV infection and development of smooth-muscle tumours (SMT).

Conclusion

With increasing numbers of individuals being on long-term immuno-suppression, EBV-associated SMTs may be encountered more frequently in the future.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Ali AE, Fazl M, Bilbao JM (2006) Primary intracranial leiomyoma: a case report and literature review. Virchows Arch 449:382–384. doi:10.1007/s00428-006-0252-z

    Article  PubMed  Google Scholar 

  2. Bargiela A, Ray JL, Diaz JLK, Martinez A (1999) Meningeal leiomyoma in an adult with AIDS: CT and MRI correlation. Neuroradioogy 41:696–698. doi:10.1007/s002340050826

    Article  CAS  Google Scholar 

  3. Baumforth KR, Young LS, Flavell KJ, Constandinou C, Murray PG (1999) The Epstein-Barr virus and its association with human cancers. Mol Pathol 52:307–322. doi:10.1136/mp. 52.6.307

    Article  CAS  PubMed  Google Scholar 

  4. Chadwick EG, Connor EJ, Hanson IC, Joshi VV, Abu-Farsakh H, Yogev R et al (1990) Tumours of smooth-muscle origin in HIV-infected children. JAMA 263:3182–3184. doi:10.1001/jama.263.23.3182

    Article  CAS  PubMed  Google Scholar 

  5. Citow JS, Kranzler L (2000) Multi-centric intracranial smooth-muscle tumour in a woman with human immuno-deficiency virus. Case report. J Neurosurg 93:701–703

    Article  CAS  PubMed  Google Scholar 

  6. Cohen JI (2000) Epstein-Barr virus infection. N Engl J Med 343:481–492. doi:10.1056/NEJM200008173430707

    Article  CAS  PubMed  Google Scholar 

  7. Deyrup AT, Lee VK, Hill CE, Cheuk W, Toh HC, Kesavan S, et al (2006) Epstein-Barr Virus associated smooth muscle tumours are distinctive mesenchymal tumours reflecting multiple infection events. A clinico-pathologic and molecular analysis of 29 tumours from 19 patients. Am J Surg Pathol 30:75–82. doi:10.1097/01.pas.0000178088.69394.7b

    Google Scholar 

  8. Kim SH, Youm JY, Song SH, Kim Y, Song KS (1999) Primary intracranial leiomyoma. Case illustration. J Neurosurg 90:171

    CAS  Google Scholar 

  9. Kleinschmidt-DeMasters BK, Mierau GW, Sze CI, Breeze RE, Greffe B, Lillehei KO et al (1998) Unusual dural and skull-based mesenchymal neoplasms: a report of four cases. Hum Pathol 29:240–245. doi:10.1016/S0046-8177(98)90042-9

    Article  CAS  PubMed  Google Scholar 

  10. Kroe DJ, Hudkins WR, Simmons JC, Blackwell CF (1967) Primary intrasellar leiomyoma. Case report. J Neurosurg 29:189–191

    Google Scholar 

  11. Kumar S, Santi M, Venzina G, Rosser T, Chandra RS, Keating R (2004) Epstein-Barr virus-associated smooth muscle tumour of the basal ganglia in an HIV+ child: case report and review of the literature. Pediatr Dev Pathol 7:198–203. doi:10.1007/s10024-003-7079-2

    Article  PubMed  Google Scholar 

  12. Lai PH, Yang CF, Huang CH, Yeh LR, Lin SL, Pan HB (1998) Primary intracranial leiomyoma: case report. Neuroradiology 40:238–241. doi:10.1007/s002340050574

    Article  CAS  PubMed  Google Scholar 

  13. Lee ES, Locker J, Nalesnik M, Reyes J, Jaffe R, Alashari M et al (1995) The association of Epstein-Barr virus with smooth-muscle tumours occurring after organ transplantation. N Engl J Med 332:19–25. doi:10.1056/NEJM199501053320104

    Article  CAS  PubMed  Google Scholar 

  14. Liebowitz D (1995) Epstein-Barr virus—an old dog with new tricks. N Engl J Med 332:55–57. doi:10.1056/NEJM199501053320112

    Article  CAS  PubMed  Google Scholar 

  15. Lin SL, Wang JS, Huang CS, Tseng HH (1996) Primary intracerebral leiomyoma: a case with eosiniphilic inclusions of actin filaments. Histopathology 28:365–369. doi:10.1046/j.1365-2559.1996.d01-440.x

    Article  CAS  PubMed  Google Scholar 

  16. McClain KL, Leach CT, Jenson HB, Joshi VV, Pollock BH, Parmley RT et al (1995) Association of Epstein-Barr virus with leiomyosarcomas in young people with AIDS. N Engl J Med 332:12–18. doi:10.1056/NEJM199501053320103

    Article  CAS  PubMed  Google Scholar 

  17. McLoughlin LC, Nord KS, Joshi VV, DiCarlo FJ, Kane MJ (1991) Disseminated leiomyosarcoma in a child with acquired immune deficiency syndrome. Cancer 67:2618–2621. doi:10.1002/1097-0142(19910515)67:10<2618::AID-CNCR2820671036>3.0.CO;2-5

    Article  CAS  PubMed  Google Scholar 

  18. Pritzker KP, Huang SN, Marshall KG (1970) Malignant tumours following immuno-suppressive therapy. Can Med Assoc J 103:1362–1365

    CAS  PubMed  Google Scholar 

  19. Rogatsch H, Bonatti H, Menet A, Larcher C, Feichtinger H, Dirnhofer S (2000) Epstein-Barr virus associated multi-centric leiomyosarcoma in an adult patient after heart transplantation: case report and review of the literature. Am J Surg Pathol 24:614–621. doi:10.1097/00000478-200004000-00018

    Article  CAS  PubMed  Google Scholar 

  20. Thierauf P, Weiland H (1978) Über ein intrakranielles leiomyom. Med Welt 29:1280–1282

    CAS  PubMed  Google Scholar 

  21. Timens W, Boes A, Vos H, Poppema S (1991) Tissue distribution of the C3d/EBC-receptor: CD21 monoclonal antibodies reactive with a variety of epithelial cells, medullary thymocytes, and peripheral T-cells. Histochemistry 95:605–611. doi:10.1007/BF00266748

    Article  CAS  PubMed  Google Scholar 

  22. Wang KC, Kim CJ, Cho BK, Kim IO, Lee HJ, Chi JG (1997) Cerebral leiomyoma in a child. JKMS 12:78–382

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Medical School of Aristotle University, Hippokration General Hospital, Thessaloniki, Greece

    Dimitris Zevgaridis, Christos Tsonidis, Parmenion Tsitsopoulos & Philippos Tsitsopoulos

  2. Department of Molecular Pathology, Mitera Maternity and Pediatric Hospital, Athens, Greece

    Nikiforos Kapranos

  3. Department of Pathology, Hippokration General Hospital, Thessaloniki, Greece

    Ioannis Venizelos

Authors
  1. Dimitris Zevgaridis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Christos Tsonidis
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nikiforos Kapranos
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ioannis Venizelos
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Parmenion Tsitsopoulos
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Philippos Tsitsopoulos
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Dimitris Zevgaridis.

Additional information

Comment

This is an interesting paper which describes a case of EBV associated primary intracranial leiomyoma in an organ transplant recipient. With large numbers of patients suffering from long term immunosuppression such a report is useful in highlighting the need to consider other rarer entities in the differential diagnosis of intracranial lesions within this group of patients.

The introduction, case report and discussion are all clearly written and are complimented by good quality illustrations of the relevant CT, MRI and histology.

Mark Walker

Southampton General Hospital

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zevgaridis, D., Tsonidis, C., Kapranos, N. et al. Epstein-Barr virus associated primary intracranial leiomyoma in organ transplant recipient: case report and review of the literature. Acta Neurochir 151, 1705–1709 (2009). https://doi.org/10.1007/s00701-009-0307-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00701-009-0307-4

Keywords

Search

Navigation