Summary
Aspergillosis of the central nervous system (CNS) is a rare, but well described disease in immuno-competent patients. We present a 65-year-old patient who developed neuro-aspergillosis 10 months after severe cranio-facial trauma (Le Fort III). He was treated successfully with surgery including stereotactic drainage and, with Amphotericin B, Liposomal Amphotericin B, and Itraconazol.
References
JM Coleman GG Hogg JV Rosenfeld KD Waters (1995) ArticleTitleInvasive central nervous system aspergillosis: cure with liposomal amphotericin B, itraconazole, and radical surgery-case report and review of the literature Neurosurgery 36 IssueID4 858–863 Occurrence Handle7596522 Occurrence Handle10.1097/00006123-199504000-00032 Occurrence Handle1:STN:280:DyaK2MzhvFKhtQ%3D%3D
DW Denning (1996) ArticleTitleTherapeutic outcome in invasive aspergillosis Clin Infect Dis 23 IssueID3 608–615 Occurrence Handle8879787 Occurrence Handle1:STN:280:DyaK2s%2FjsVWgsw%3D%3D
DR DeLone RA Goldstein G Petermann MS Salamat JM Miles SJ Knechtle WD Brown (1999) ArticleTitleDisseminated aspergillosis involving the brain: distribution and imaging characteristics Am J Neuroradiol 20 IssueID9 1597–1604 Occurrence Handle10543627 Occurrence Handle1:STN:280:DC%2BD3c%2FgvV2ksA%3D%3D
EA Elgamal WR Murshid (2000) ArticleTitleIntracavitary administration of amphotericin B in the treatment of cerebral aspergillosis in a non immune-compromised patient: case report and review of the literature Br J Neurosurg 14 IssueID2 137–141 Occurrence Handle10889888 Occurrence Handle10.1080/02688690050004589 Occurrence Handle1:STN:280:DC%2BD3czkvVeltg%3D%3D
ML Goodman RJ Coffey (1989) ArticleTitleStereotactic drainage of Aspergillus brain abscess with long-term survival: case report and review Neurosurgery 24 IssueID1 96–99 Occurrence Handle2648179 Occurrence Handle10.1097/00006123-198901000-00016 Occurrence Handle1:STN:280:DyaL1M7ot1Cisw%3D%3D
DE Harris DS Enterline (1997) ArticleTitleNeuroimaging of AIDS. I. Fungal infections of the central nervous system Neuroimaging Clin N Am 7 IssueID2 187–198 Occurrence Handle9113685 Occurrence Handle1:STN:280:DyaK2s3mvV2lsw%3D%3D
SJ Lin J Schranz SM Teutsch (2001) ArticleTitleAspergillosis case-fatality rate: systematic review of the literature Clin Infect Dis 32 IssueID3 358–366 Occurrence Handle11170942 Occurrence Handle10.1086/318483 Occurrence Handle1:STN:280:DC%2BD38%2Fgs12lsg%3D%3D
I Lutsar S Roffey P Troke (2003) ArticleTitleVoriconazole concentrations in the cerebrospinal fluid and brain tissue of guinea pigs and immuno-compromised patients Clin Infect Dis 37 IssueID5 728–732 Occurrence Handle12942409 Occurrence Handle10.1086/377131
ML Kerkmann R Blaschke-Hellmessen HD Mikulin (1994) ArticleTitleSuccessful treatment of cerebral aspergillosis by stereotactic operation and antifungal therapy Mycoses 37 IssueID3–4 123–126 Occurrence Handle7845417 Occurrence Handle1:STN:280:DyaK2M7ksl2hsw%3D%3D
DG Kim SC Hong HJ Kim JG Chi MH Han KS Choi DH Han (1993) ArticleTitleCerebral aspergillosis in immunologically competent patients Surg Neurol 40 IssueID4 326–331 Occurrence Handle8211644 Occurrence Handle10.1016/0090-3019(93)90145-Q Occurrence Handle1:STN:280:DyaK2c%2FisVGisw%3D%3D
S Schwartz E Thiel (1997) ArticleTitleClinical presentation of invasive aspergillosis Mycoses 40 IssueIDSuppl 2 21–24 Occurrence Handle9476500 Occurrence Handle10.1111/j.1439-0507.1997.tb00559.x
L Tveten AC Loken T Hauge (1965) ArticleTitleAspergillosis cerebri. Report of a case Acta Chir Scand 130 149–156 Occurrence Handle14346070 Occurrence Handle1:STN:280:DyaF2M7ltV2kuw%3D%3D
TJ Walsh DB Hier LR Caplan (1985) ArticleTitleAspergillosis of the central nervous system: clinicopathological analysis of 17 patients Ann Neurol 18 IssueID5 574–582 Occurrence Handle3935042 Occurrence Handle10.1002/ana.410180511 Occurrence Handle1:STN:280:DyaL28%2FnsFygtQ%3D%3D
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Marinovic, T., Skrlin, J., Vilendecic, M. et al. Multiple Aspergillus brain abscesses in immuno-competent patient with severe cranio-facial trauma. Acta Neurochir (Wien) 149, 629–632 (2007). https://doi.org/10.1007/s00701-007-1148-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00701-007-1148-7