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Cerebral vasospasm in patients with unruptured intracranial aneurysms

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Summary

Intracranial arterial vasospasm is a typical sequela of subarachnoid haemorrhage. The association between symptomatic vasospasm and unruptured aneurysms has been sporadically presented in the literature. The pathogenesis of this unusual entity is unclear. The published cases were collected in this review and analysed with regard to timing, clinical presentation and possible relationship with surgical factors. We also added an illustrative case which was recently observed in our department.

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References

  • C Arienta S Balbi M Caroli G Fumagalli (1991) ArticleTitleDepletion of calcitonin gene-related peptide in perivascular nerves during acute phase of posthemorrhagic vasospasm in the rabbit. Brain Res Bull 27 605–609 Occurrence Handle10.1016/0361-9230(91)90034-H Occurrence Handle1756379

    Article  PubMed  Google Scholar 

  • SM Bloomfield VK Sonntag (1985) ArticleTitleDelayed cerebral vasospasm after uncomplicated operation on an unruptured aneurysm: case report. Neurosurgery 17 792–796 Occurrence Handle4069331

    PubMed  Google Scholar 

  • A Buki Z Horvath I Kallo Z Liposits I Lengvari TP Doczi (1999) ArticleTitlePeptidergic innervation of human cerebral blood vessels and saccular aneurysms. Acta Neuropathol (Berl) 98 383–388 Occurrence Handle10.1007/s004010051098

    Article  Google Scholar 

  • De Long (1980) ArticleTitleComment in: severe vasospasm with an unruptured aneurysm: case report. Neurosurgery 6 92–95 Occurrence Handle7354904

    PubMed  Google Scholar 

  • L Edvinsson R Juul I Jansen (1994) ArticleTitlePerivascular neuropeptides (NPY, VIP, CGRP and SP) in human brain vessels after subarachnoid haemorrhage. Acta Neurol Scand 90 324–330 Occurrence Handle7534026

    PubMed  Google Scholar 

  • Fein JM (1980) Unruptured aneurysms and cerebral spasm. In: Wilkins RH (ed) Cerebral arterial spasm: Proceedings of the Second International Workshop, Baltimore, pp 499–504

  • J Fein R Boulos (1973) ArticleTitleLocal cerebral blood flow in experimental middle cerebral artery vasospasm. J Neurosurg 39 337–347 Occurrence Handle4200268

    PubMed  Google Scholar 

  • JM Fein (1976) ArticleTitleBrain energetics and circulatory control after subarachnoid hemorrhage. J Neurosurg 45 498–507 Occurrence Handle823308

    PubMed  Google Scholar 

  • JM Fein WJ Flor SL Cohan J Parkhurst (1974) ArticleTitleSequential changes of vascular ultrastructure in experimental cerebral vasospasm. Myonecrosis of subarachnoid arteries. J Neurosurg 41 49–58 Occurrence Handle4210067

    PubMed  Google Scholar 

  • Findlay JM (2003) Cerebral vasospasm. In: Winn HR (ed) Youmanàs neurological surgery, 5th edn. WB Saunders, Philadelphia PA, pp 1839–1864

  • JM Findlay RL Macdonald BK Weir MG Grace (1991) ArticleTitleSurgical manipulation of primate cerebral arteries in established vasospasm. J Neurosurg 75 425–432 Occurrence Handle1869944

    PubMed  Google Scholar 

  • CM Fisher JP Kistler JM Davis (1980) ArticleTitleRelation of cerebral vasospasm to subarachnoid hemorrhage visualized by computerized tomographic scanning. Neurosurgery 6 1–9 Occurrence Handle7354892

    PubMed  Google Scholar 

  • P Friedman HH Gass M Magidson (1983) ArticleTitleVasospasm with an unruptured and unoperated aneurysm. Surg Neurol 19 21–25 Occurrence Handle10.1016/0090-3019(83)90204-5 Occurrence Handle6828990

    Article  PubMed  Google Scholar 

  • K Hosoda S Fujita T Kawaguchi Y Shose S Hamano M Iwakura (1999) ArticleTitleEffect of clot removal and surgical manipulation on regional cerebral blood flow and delayed vasospasm in early aneurysm surgery for subarachnoid hemorrhage. Surg Neurol 51 81–88 Occurrence Handle10.1016/S0090-3019(97)00508-9 Occurrence Handle9952128

    Article  PubMed  Google Scholar 

  • R Juul L Edvinsson SE Gisvold R Ekman AO Brubakk TA Fredriksen (1990) ArticleTitleCalcitonin gene-related peptide-LI in subarachnoid haemorrhage in man. Signs of activation of the trigemino-cerebrovascular system? Br J Neurosurg 4 171–179 Occurrence Handle2204353

    PubMed  Google Scholar 

  • M Mizukami T Takemae T Tazawa T Kawase T Matsuzaki (1980) ArticleTitleValue of computed tomography in the prediction of cerebral vasospasm after aneurysm rupture. Neurosurgery 7 583–586 Occurrence Handle7207754

    PubMed  Google Scholar 

  • S Nishizawa D Chen T Yokoyama N Yokota S Otha (2000) ArticleTitleEndothelin-1 initiates the development of vasospasm after subarachnoid haemorrhage through protein kinase C activation, but does not contribute to prolonged vasospasm. Acta Neurochir (Wien) 142 1409–1415 Occurrence Handle10.1007/s007010070013

    Article  Google Scholar 

  • K Nozaki Y Uemura S Okamoto H Kikuchi N Mizuno (1990) ArticleTitleOrigins and distribution of cerebrovascular nerve fibers showing calcitonin gene-related peptide-like immunoreactivity in the major cerebral artery of the dog. J Comp Neurol 297 219–226 Occurrence Handle10.1002/cne.902970205 Occurrence Handle2370321

    Article  PubMed  Google Scholar 

  • A Pasqualin (1998) ArticleTitleEpidemiology and pathophysiology of cerebral vasospasm following subarachnoid hemorrhage. J Neurosurg Sci 42 15–21 Occurrence Handle9800597

    PubMed  Google Scholar 

  • Peerless SJ (1980) Postoperative cerebral vasospasm without SAH. In: Wilkins RH (ed) Cerebral arterial spasm: Proceedings of the Second International Workshop. William and Wilkins, Baltimore, pp 496–498

  • RB Raynor HD Messer (1980) ArticleTitleSevere vasospasm with an unruptured aneurysm: case report. Neurosurgery 6 92–95 Occurrence Handle7354904

    PubMed  Google Scholar 

  • S Roux BM Loffler GA Gray U Sprecher M Clozel JP Clozel (1995) ArticleTitleThe role of endothelin in experimental cerebral vasospasm. Neurosurgery 37 78–85 Occurrence Handle8587695

    PubMed  Google Scholar 

  • C Schaller E Klemm D Haun J Schramm B Meyer (2002) ArticleTitleThe transsylvian approach is “minimally invasive” but not “atraumatic”. Neurosurgery 51 971–976 Occurrence Handle10.1097/00006123-200210000-00022 Occurrence Handle12234405

    Article  PubMed  Google Scholar 

  • V Seifert BM Loffler M Zimmermann S Roux D Stolke (1995) ArticleTitleEndothelin concentrations in patients with aneurysmal subarachnoid hemorrhage. Correlation with cerebral vasospasm, delayed ischemic neurological deficits, and volume of hematoma. J Neurosurg 82 55–62 Occurrence Handle7815135

    PubMed  Google Scholar 

  • Simeone F, Peerless SJ (1975) Prolonged cerebral vasospasm without subarachnoid hemorrhage. In: Smith Robertson JT (ed) Subarachnoid hemorrhage and cerebrovascular spasm. Charles C Thomas, Springfield, IL, pp 206–225

  • R Suzuki H Masaoka Y Hirata F Marumo E Isotani K Hirakawa (1992) ArticleTitleThe role of endothelin-1 in the origin of cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage. J Neurosurg 77 96–100 Occurrence Handle1607979

    PubMed  Google Scholar 

  • SA Tsementzis ER Hitchcock A DeCothi JS Gill (1985) ArticleTitleComparative studies of the diagnostic value of cerebrospinal fluid spectrophotometry and computed tomographic scanning in subarachnoid hemorrhage. Neurosurgery 17 908–912 Occurrence Handle4080123

    PubMed  Google Scholar 

  • K Tureyen HO Nazlioglu T Alkan N Kahveci E Korfali (2005) ArticleTitleSingle or multiple small subarachnoid hemorrhages by puncturing a small branch of the rat basilar artery causes chronic cerebral vasospasm. Neurosurgery 56 382–390 Occurrence Handle10.1227/01.NEU.0000148004.61621.D2 Occurrence Handle15670386

    Article  PubMed  Google Scholar 

  • M Vermeulen D Hasan BG Blijenberg A Hijdra GJ van (1989) ArticleTitleXanthochromia after subarachnoid haemorrhage needs no revisitation. J Neurol Neurosurg Psychiatry 52 826–828 Occurrence Handle2769274

    PubMed  Google Scholar 

  • RH Wilkins (1975) ArticleTitleHypothalamic dysfunction and intracranial arterial spasms. Surg Neurol 4 472–480 Occurrence Handle1103337

    PubMed  Google Scholar 

  • JL Wilson JR Feild (1974) ArticleTitleThe production of intracranial vascular spasm by hypothalamic extract. J Neurosurg 40 473–479 Occurrence Handle4814378

    PubMed  Google Scholar 

  • M Zimmermann V Seifert (1998) ArticleTitleEndothelin and subarachnoid hemorrhage: an overview. Neurosurgery 43 863–875 Occurrence Handle10.1097/00006123-199810000-00083 Occurrence Handle9766314

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Cattedra di Neurochirurgia, Università degli Studi di Perugia, IRCCS Neuromed, Pozzilli, Italy

    S. Paolini

  2. Department of Neurosurgery, Illinois Neurological Institute, University of Illinois College of Medicine at Peoria, Peoria, IL, USA

    Y. Kanaan, A. Wagenbach & G. Lanzino

  3. Department of Radiology, Illinois Neurological Institute, University of Illinois College of Medicine at Peoria, Peoria, IL, USA

    K. Fraser

Authors
  1. S. Paolini
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  2. Y. Kanaan
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  3. A. Wagenbach
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  4. K. Fraser
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  5. G. Lanzino
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Paolini, S., Kanaan, Y., Wagenbach, A. et al. Cerebral vasospasm in patients with unruptured intracranial aneurysms. Acta Neurochir (Wien) 147, 1181–1188 (2005). https://doi.org/10.1007/s00701-005-0613-4

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  • DOI: https://doi.org/10.1007/s00701-005-0613-4

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