Abstract
The development of a gold nanoparticle aptamer assay is persued for rapid and sensitive determination of histamine in foodstuffs, which could be deployed for on-site use. The assay is based on a histamine-specific aptamer and gold nanoparticles and the salt-induced aggregation of the particles in the presence of histamine indicated by the color change from red to blue. Gold nanoparticle size, salt type, and concentration as well as aptamer concentration were optimized, and using optimum conditions, a limit of detection of 8 nM (~ 0.05 mg/kg) was obtained. Finally, the aptamer AuNP assay was applied to the determination of histamine in quality control fish samples. The histamine levels of these samples had previously been determined using HPLC and commercial ELISA kits by numerous independent laboratories and a good correlation was obtained. The developed AuNP assay is rapid, sensitive, and reproducible.
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Acknowledgments
The authors are grateful to King Abdulaziz University (Saudi Arabia) for financing the collaborative project “Ultrasensitive, extremely rapid lateral flow assays exploiting nanoparticles for the detection of biogenic amines, detection of adulteration of food with meat products and identification of contaminating meat and viruses.”.
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Lerga, T.M., Skouridou, V., Bermudo, M.C. et al. Gold nanoparticle aptamer assay for the determination of histamine in foodstuffs. Microchim Acta 187, 452 (2020). https://doi.org/10.1007/s00604-020-04414-4
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DOI: https://doi.org/10.1007/s00604-020-04414-4