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A cardiac troponin I photoelectrochemical immunosensor: nitrogen-doped carbon quantum dots–bismuth oxyiodide–flower-like SnO2

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Abstract

A novel photoelectrochemical (PEC) immunosensor for the determination of cardiac troponin I (cTnI) was constructed. The flower-like stannic oxide (SnO2) with large specific surface area was prepared by hydrothermal synthesis. Nitrogen-doped carbon quantum dots (NCQDs) with excellent surface property were used as a sensitizer for SnO2. Bismuth oxyiodide (BiOI) is a narrow band gap (1.83 eV) nanomaterial, which was firstly modified on NCQDs-sensitized SnO2 through in situ growth method. After NCQDs with small size and BiOI nanoparticles are successively combined with SnO2, the SnO2/NCQDs/BiOI microflower was obtained, which possessed good photochemical properties. Using visible light as excitation source and ascorbic acid (AA) as electron donor, the ultrasensitive and quantitative determination of cTnI was realized by detecting the changes of photocurrent under different concentrations of cTnI. The PEC immunosensor showed a large-scaled response (0.001–100 ng mL−1) and a low detection limit (0.3 pg mL−1) under optimised experimental conditions. The sensor has potential clinical value in the prediction and diagnosis of cardiovascular diseases in elderly patients with diabetes.

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Funding

This research was financially supported by the Innovation team project of colleges and universities in Jinan (No. 2019GXRC027), the National Natural Science Foundation of China (Nos. 21775054, 21775053, 21575050, 21777056, 21505051), the National Key Scientific Instrument and Equipment Development Project of China (No. 21627809), the Natural Science Foundation of Shandong Province (No. ZR2017MB027), and the Jinan Scientific Research Leader Workshop Project (2018GXRC024).

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Authors and Affiliations

  1. Collaborative Innovation Center for Green Chemical Manufacturing and Accurate Detection, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, People’s Republic of China

    Dawei Fan, Xin Liu, Xinrong Shao, Yong Zhang, Nuo Zhang, Xueying Wang, Qin Wei & Huangxian Ju

  2. Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, People’s Republic of China

    Dawei Fan, Xin Liu, Xinrong Shao, Yong Zhang, Nuo Zhang, Xueying Wang, Qin Wei & Huangxian Ju

  3. Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, People’s Republic of China

    Huangxian Ju

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  1. Dawei Fan
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  2. Xin Liu
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Fan, D., Liu, X., Shao, X. et al. A cardiac troponin I photoelectrochemical immunosensor: nitrogen-doped carbon quantum dots–bismuth oxyiodide–flower-like SnO2. Microchim Acta 187, 332 (2020). https://doi.org/10.1007/s00604-020-04302-x

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