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A silica fiber coated with a ZnO-graphene oxide nanocomposite with high specific surface for use in solid phase microextraction of the antiepileptic drugs diazepam and oxazepam

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Abstract

A novel ZnO-graphene oxide nanocomposite was prepared and is shown to be a viable coating on fused silica fibers for use in solid phase microextraction (SPME) of diazepam and oxazepam from urine, this followed by thermal desorption and gas chromatographic quantitation using a flame ionization detector. A central composite design was used to optimize extraction time, salt percentage, sample pH and desorption time. Limits of detection are 0.5 μg·L−1 for diazepam and 1.0 μg·L−1 for oxazepam. Repeatability and reproducibility for one fiber (n = 4), expressed as the relative standard deviation at a concentration of 50 μg·L−1, are 8.3 and 11.3% for diazepam, and 6.7 and 10.1% for oxazepam. The fiber-to-fiber reproducibility is <17.6%. The calibration plots are linear in the 5.0–1000 μg·L−1 diazepam concentration range, and from 1.0–1000 μg·L−1 in case of oxazepam. The fiber for SPME has high chemical and thermal stability (even at 280 °C) after 50 extractions, and does not suffer from a reduction in the sorption capacity.

A hydrothermal method was introduced for preparation of ZnO- GO nano composite on a fused silica fiber as solid phase microextraction with high mechanical, chemical stability and long service life

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Acknowledgments

The author would like to thank from Iran Nanotechnology Initiative Council.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, University of Qom, Qom, 3716146611, Iran

    Reza Alizadeh & Maryam Salami

  2. Department of Analytical Chemistry, Faculty of Chemistry, K.N. Toosi University of Technology, Tehran, 19697 64499, Iran

    Shahram Seidi

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  1. Reza Alizadeh
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  2. Maryam Salami
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Correspondence to Reza Alizadeh.

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Alizadeh, R., Salami, M. & Seidi, S. A silica fiber coated with a ZnO-graphene oxide nanocomposite with high specific surface for use in solid phase microextraction of the antiepileptic drugs diazepam and oxazepam. Microchim Acta 185, 312 (2018). https://doi.org/10.1007/s00604-018-2850-2

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