Skip to main content
SpringerLink
Log in

Voltammetric determination of 5-hydroxytryptamine based on the use of platinum nanoparticles coated with molecularly imprinted silica

  • Original Paper
  • Published:
Microchimica Acta Aims and scope Submit manuscript

Abstract

The authors describe an electrochemical sensor for the determination of 5-hydroxytryptamine (5-HT; serotonin). It is based on the use of platinum nanoparticles (PtNPs) coated with molecularly imprinted silica (MIS). The MIS-coated PtNPs were prepared from 5-HT, PtNPs, phenyltrimethoxysilane and tetraethoxysilane that act as template, support, functional monomer and cross-linker, respectively. The MIS-coated PtNPs were characterized by Fourier transfer infrared spectroscopy and transmission electron microscopy. The MIS-coated PtNPs were drop-cast onto a glassy carbon electrode (GCE) to obtain an electrochemical sensor for 5-HT which exhibited fast response and high recognition ability for 5-HT. The imprinting factor of this electrode for 5-HT is 4.12, which is higher than that for its analogs. Under optimized conditions and at a typical working potential of 0.29 V (vs. Hg/Hg2Cl2), the electrode has a linear response in the 0.05–80 μM 5-HT concentration range and a 0.02 μM detection limit. The electrode was successfully applied to the determination of 5-HT in human serum samples.

Molecularly imprinted silica-coated platinum nanoparticles were prepared using surface imprinting technique. A glassy carbon electrode modified with the surface imprinted material exhibits fast response in detecting 5-hydroxytryptamine, a low detection limit, good selectivity, reproducibility and stability.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1
Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Ressler KJ, Nemeroff CB (2000) Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders. Depress Anxiety 12:2–19

    Article  Google Scholar 

  2. Xue C, Wang X, Zhu WY, Han Q, Zhu CH, Hong JL, Zhou XM, Jiang HJ (2014) Electrochemical serotonin sensing interface based on double-layered membrane of reduced graphene oxide/polyaniline nanocomposites and molecularly imprinted polymers embedded with gold nanoparticles. Sensors Actuators B Chem 196:57–63

    Article  CAS  Google Scholar 

  3. Shi HM, Wang B, Niu LM, Cao MS, Kang WJ, Lian KQ, Zhang PP (2017) Trace level determination of 5-hydroxytryptamine and its related indoles in amniotic fluid by gas chromatography-mass spectrometry. J Pharm Biomed Anal 143:176–182

    Article  CAS  Google Scholar 

  4. Wu D, Xie H, Lu HF, Li W, Zhang QL (2016) Sensitive determination of norepinephrine, epinephrine, dopamine and 5-hydroxytryptamine by coupling HPLC with [Ag(HIO6)2]5−-luminol chemiluminescence detection. Biomed Chromatogr 30:1458–1466

    Article  CAS  Google Scholar 

  5. Israël M (2003) A chemiluminescent serotonin assay. Neurochem Int 42:215–220

    Article  Google Scholar 

  6. Zhang LL, Zhao YS, Huang JM, Zhao SL (2014) Simultaneous quantification of 5-hydroxyindoleacetic acid and 5-hydroxytryptamine by capillary electrophoresis with quantum dot and horseradish peroxidase enhanced chemiluminescence detection. J Chromatogr B 967:190–194

    Article  CAS  Google Scholar 

  7. Zhang LM, Wang JL, Tian Y (2014) Electrochemical in-vivo sensors using nanomaterials made from carbon species, noble metals, or semiconductors. Microchim Acta 181:1471–1484

    Article  CAS  Google Scholar 

  8. Taleat Z, Khoshroo A, Mazloum-Ardakani M (2014) Screen-printed electrodes for biosensing: a review (2008–2013). Microchim Acta 181:865–891

    Article  CAS  Google Scholar 

  9. Sanghavi BJ, Wolfbeis OS, Hirsch T, Swami NS (2015) Nanomaterial-based electrochemical sensing of neurological drugs and neurotransmitters. Microchim Acta 182:1–41

    Article  CAS  Google Scholar 

  10. Zhang CC, Tang J, Huang LL, Li YP, Tang DP (2017) In-situ amplified voltammetric immunoassay for ochratoxin A by coupling a platinum nanocatalyst based enhancement to a redox cycling process promoted by an enzyme mimic. Microchim Acta 184:2445–2453

    Article  CAS  Google Scholar 

  11. Uson L, Hueso JL, Sebastian V, Arenal R, Florea I, Irusta S, Arruebo M, Santamaria J (2017) In-situ preparation of ultra-small Pt nanoparticles within rod-shaped mesoporous silica particles: 3-D tomography and catalytic oxidation of n-hexane. Catal Commun 100:93–97

    Article  CAS  Google Scholar 

  12. Yano K, Zhang SY, Pan XQ, Tatsuda N (2014) Investigation of the stability of Platinum nanoparticles incorporated in mesoporous silica with different pore sizes. J Colloid Interface Sci 421:22–26

    Article  CAS  Google Scholar 

  13. Oh J, Kim H (2013) Synthesis of core–shell nanoparticles with a Pt nanoparticle core and a silica shell. Curr Appl Phys 13(1):130–136

    Article  Google Scholar 

  14. Prashar AK, Mayadevi S, Rajamohanan P, Devi RN (2011) In situ encapsulation of Pt nanoparticles in mesoporous silica: Synthesis, characterisation and effect of particle size on CO oxidation. App Catal A 403:91–97

    Article  CAS  Google Scholar 

  15. Bornacelli J, Silva-Pereyra H, Rodríguez-Fernández L, Avalos-Borja M, Oliver A (2016) From photoluminescence emissions to plasmonic properties in platinum nanoparticles embedded in silica by ion implantation. J Lumin 179:8–15

    Article  CAS  Google Scholar 

  16. Tang H, Chen JR, Zeng YB, Li ZY, Huang H, Li L (2016) An electrochemical sensor for 1-naphthylamine based on a novel composite of cyclodextrin-graphene and molecularly imprinted poly(vinylferrocene). Anal Methods 8:1681–1689

    Article  CAS  Google Scholar 

  17. Alizadeh T, Hamidi N, Ganjali MR, Rafiei F (2018) Determination of subnanomolar levels of mercury (II) by using a graphite paste electrode modified with MWCNTs and Hg (II)-imprinted polymer nanoparticles. Microchim Acta 185:16

    Article  Google Scholar 

  18. Yu DJ, Zeng YB, Qi YX, Zhou TS, Shi GY (2012) A novel electrochemical sensor for determination of dopamine based on AuNPs@SiO2 core-shell imprinted composite. Biosens Bioelectron 38(1):270–277

    Article  CAS  Google Scholar 

  19. Qian K, Deng QL, Fang GZ, Wang JP, Pan MF, Wang S, Pu YH (2016) Metal-organic frameworks supported surface-imprinted nanoparticles for the sensitive detection of metolcarb. Biosens Bioelectron 79:359–363

    Article  CAS  Google Scholar 

  20. Wang X, Wang YY, Ye XX, Wu T, Deng HP, Wu P, Li CY (2017) Sensing platform for neuron specific enolase based on molecularly imprinted polymerized ionic liquids in between gold nanoarrays. Biosens Bioelectron 99:34–39

    Article  Google Scholar 

  21. Bali Prasad B, Kumar A, Singh R (2017) Synthesis of novel monomeric graphene quantum dots and corresponding nanocomposite with molecularly imprinted polymer for electrochemical detection of an anticancerous ifosfamide drug. Biosens Bioelectron 94:1–9

    Article  CAS  Google Scholar 

  22. Hoa LT, Sun KG, Hur SH (2015) Highly sensitive non-enzymatic glucose sensor based on Pt nanoparticle decorated graphene oxide hydrogel. Sensors Actuators B Chem 210:618–623

    Article  CAS  Google Scholar 

  23. Liu M, Zhang J, Yu WW, Liu J (2011) Synthesis of PVP-stabilized Pt/Ru colloidal nanoparticles by ethanol reduction and their catalytic properties for selective hydrogenation of ortho-chloronitrobenzene. J Catal 278:1–7

    Article  CAS  Google Scholar 

  24. Patel AN, Unwin PR, Macpherson JV (2013) Investigation of film formation properties during electrochemical oxidation of serotonin (5-HT) at polycrystalline boron doped diamond. Phys Chem Chem Phys 15:18085–18092

    Article  CAS  Google Scholar 

  25. Gupta P, Goyal RN (2014) Polymelamine modified edge plane pyrolytic graphite sensor for the electrochemical assay of serotonin. Talanta 120:17–22

    Article  CAS  Google Scholar 

  26. Leng Y, Sato K, Li JG, Ishigaki T, Iijima M, Kamiya H, Yoshida T (2009) Iron nanoparticles dispersible in both ethanol and water for direct silica coating. Powder Technol 196:80–84

    Article  CAS  Google Scholar 

  27. Tertiș M, Cernat A, Lacatiș D, Florea A, Bogdan D, Suciu M, Săndulescu R, Cristea C (2017) Highly selective electrochemical detection of serotonin on polypyrrole and gold nanoparticles-based 3D architecture. Electrochem Commun 75:43–47

    Article  Google Scholar 

  28. Gomez FJV, Martín A, Silva MF, Escarpa A (2015) Screen-printed electrodes modified with carbon nanotubes or graphene for simultaneous determination of melatonin and serotonin. Microchim Acta 182:1925–1931

    Article  CAS  Google Scholar 

  29. Wang ZH, Xu LJ, Wu GF, Zhu LQ, Lu XQ (2015) Development and application of the serotonin voltametric sensors based on molecularly imprinting technology. J Electrochem Soc 162:B201–B206

    Article  CAS  Google Scholar 

  30. Ran G, Chen CN, Gu C (2015) Serotonin sensor based on a glassy carbon electrode modified with multiwalled carbon nanotubes, chitosan and poly (p-aminobenzenesulfonate). Microchim Acta 182:1323–1328

    Article  CAS  Google Scholar 

  31. Ran G, Chen X, Xia Y (2017) Electrochemical detection of serotonin based on a poly(bromocresol green) film and Fe3O4 nanoparticles in a chitosan matrix. RSC Adv 7:1847–1851

    Article  CAS  Google Scholar 

  32. Sun DF, Li HJ, Li MJ, Li CP, Dai HL, Sun DZ, Yang BH (2018) Electrodeposition synthesis of a NiO/CNT/PEDOT composite for simultaneous detection of dopamine, serotonin, and tryptophan. Sensors Actuators B Chem 259:433–442

    Article  CAS  Google Scholar 

  33. Wang F, Wu YJ, Lu K, Ye BX (2013) A simple but highly sensitive and selective calixarene-based voltammetric sensor for serotonin. Electrochim Acta 87:756–762

    Article  CAS  Google Scholar 

  34. Babaei A, Taheri AR, Aminikhah M (2013) Nanomolar simultaneous determination of levodopa and serotonin at a novel carbon ionic liquid electrode modified with Co(OH)2 nanoparticles and multi-walled carbon nanotubes. Electrochim Acta 90:317–325

    Article  CAS  Google Scholar 

Download references

Acknowledgments

This work was supported by the National Natural Science Foundation of China (No. 21507041, 21677060), the Zhejiang Provincial Natural Science Foundation of China under Grant No. LY16B050007 and LQ14B050002, the Program for Public technology of Zhejiang Province (No. LGF18B050004), and the Program for Science and Technology of Jiaxing (2017AY33034).

Author information

Authors and Affiliations

  1. College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing, 314001, People’s Republic of China

    Yiwen Yang, Yanbo Zeng, Chuangui Tang, Xudong Zhu, Xing Lu, Lingyu Liu & Lei Li

  2. School of Petrochemical Engineering, Changzhou University, Changzhou, 213016, People’s Republic of China

    Chuangui Tang, Xudong Zhu, Lingyu Liu & Zhidong Chen

  3. College of Chemistry and Life Science, Zhejiang Normal University, Jinhua, 321004, People’s Republic of China

    Xing Lu

Authors
  1. Yiwen Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yanbo Zeng
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Chuangui Tang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Xudong Zhu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Xing Lu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Lingyu Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Zhidong Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Lei Li
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Yanbo Zeng or Lei Li.

Ethics declarations

The author(s) declare that they have no competing interests.

Electronic supplementary material

ESM 1

(DOC 6024 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yang, Y., Zeng, Y., Tang, C. et al. Voltammetric determination of 5-hydroxytryptamine based on the use of platinum nanoparticles coated with molecularly imprinted silica. Microchim Acta 185, 219 (2018). https://doi.org/10.1007/s00604-018-2755-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s00604-018-2755-0

Keywords

Search

Navigation