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Ultrathin NiCo2O4 nanowalls supported on a 3D nanoporous gold coated needle for non-enzymatic amperometric sensing of glucose

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Abstract

A disposable needle-type of hybrid electrode was prepared from a core of stainless steel needle whose surface was modified with a 3D nanoporous gold/NiCo2O4 nanowall hybrid structure for electrochemical non-enzymatic glucose detection. This hybrid electrode, best operated at 0.45 V (vs. SCE) in solutions of pH 13 has a linear response in the 0.01 to 21 mM glucose concentration range, a response time of <1 s, and a 1 μM detection limit (at an S/N ratio of 3). The remarkable enhancement compared to the solid gold/NiCo2O4 and stainless steel/NiCo2O4 hybrid electrodes in electrochemical performance is assumed to originate from the good electrical conductivity and large surface area of the hybrid electrode, which enhance the transport of mass and charge during electrochemical reactions. This biosensor was also applied to real sample analysis with little interferences. The electrode is disposable and considered to be a promising tool for non-enzymatic sensing of glucose in a variety of practical situations.

Ultrathin NiCo2O4 nanowalls supported on nanoporous gold that is coated on a stainless steel needle was fabricated for sensitive non-enzymatic amperometric sensing of glucose.

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Scheme 1|
Fig. 1: Characterization of nanoporous gold needle
Fig. 2: Morphological characterization
Fig. 3: Electrochemical characterization
Fig. 4: Amperometric glucose detection

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Acknowledgements

This work was financially supported by the National Key Research and Development Program of China (2016YFA0200400), the Natural Science Foundation of China (51571100, 21275064, 51602305), the Fundamental Research Funds for the Central Universities, and the Program for JLU Science and Technology Innovative Research Team (JLUSTIRT, 2017TD-09).

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Authors and Affiliations

  1. State Key Laboratory of Automotive Simulation and Control, Department of Materials Science, Jilin University, Changchun, 130012, China

    Weiwei Li, Shuting Wei, Xiaolin Zhang, Ying Wang, Lei Zhang & Xiaoqiang Cui

  2. The Second Hospital of Jilin University, Changchun, 130041, People’s Republic of China

    Hui Qi

  3. The First Hospital of Jilin University, Changchun, 130041, People’s Republic of China

    Baogang Wang

  4. Key Laboratory for Renewable Energy, Institute of Physics, Chinese Academy of Sciences, Beijing, 100190, China

    Qiyu Wang

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  1. Weiwei Li
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  2. Hui Qi
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Correspondence to Xiaoqiang Cui.

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Li, W., Qi, H., Wang, B. et al. Ultrathin NiCo2O4 nanowalls supported on a 3D nanoporous gold coated needle for non-enzymatic amperometric sensing of glucose. Microchim Acta 185, 124 (2018). https://doi.org/10.1007/s00604-017-2663-8

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