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A molecularly imprinted polymer for solid phase extraction of allantoin

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Abstract

We describe a molecularly imprinted polymer (MIP) for the solid-phase extraction of the skin protectant allantoin. The MIP was deposited on the surface of monodisperse silica microspheres possessing acroyl groups on the surface (MH-SiO2). The resulting MIP microspheres (MH-SiO2@MIP) showed a 3.4-fold higher adsorption capacity and a 1.9-fold better selectivity for allantoin than the respective non-imprinted polymer (MH-SiO2@NIP). The monolayer adsorption capacities of the MH-SiO2@MIP and the MH-SiO2@NIP were calculated with the help of the Langmuir model and found to be 6.8 and 1.9 mg•g−1, respectively. Adsorption kinetics fit a pseudo-second order rate mechanism, with an initial adsorption rate of 1.44 for the MH-SiO2@MIP, and of 0.07 mg•g−1•min−1 for the MH-SiO2@NIP. The material can be regenerated, and its adsorption capacity for allantoin remains stable for at least five regeneration cycles. It was successfully used as a sorbent for the selective solid-phase extraction of allantoin from Rhizoma dioscoreae.

A molecularly imprinted polymer for the selective separation of allantoin was developed. It was successfully used as a sorbent for the selective solid-phase extraction of allantoin from Rhizoma dioscoreae.

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Acknowledgments

This work was financially supported by Natural Science Foundation of China (50978132, 51178213, 51238002, 51272099, 51308278), Program for New Century Excellent Talents in University (NCET-11-1004), Cultivating Program for Young Scientists of Jiangxi Province of China (20112BCB23016), National High Technology Research and Development Program of China (2009AA062905, 2011AA060604), Natural Science Foundation of Jiangxi Province (20122BAB213014, 20114BAB203018) and Department of Education Fund of Jiangxi Province (Grant GJJ11508).

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Authors and Affiliations

  1. Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle, Nanchang, 330063, Peoples Republic of China

    Xianwen Zhong, Fang Deng, Yuehua Wang & Xubiao Luo

  2. College of Environmental and Chemical Engineering, Nanchang Hangkong University, Nanchang, 330063, Peoples Republic of China

    Xianwen Zhong, Fang Deng, Yuehua Wang & Xubiao Luo

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  1. Xianwen Zhong
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  2. Fang Deng
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  3. Yuehua Wang
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Correspondence to Yuehua Wang or Xubiao Luo.

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Zhong, X., Deng, F., Wang, Y. et al. A molecularly imprinted polymer for solid phase extraction of allantoin. Microchim Acta 180, 1453–1460 (2013). https://doi.org/10.1007/s00604-013-1087-3

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  • DOI: https://doi.org/10.1007/s00604-013-1087-3

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