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A molecularly imprinted polymer for the determination of neopterin

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Abstract

A molecularly imprinted polymer (MIP) for the specific retention of neopterin has been developed. A set of 6 polymers was prepared by radical polymerization under different experimental condition using methacrylic acid as functional monomer and ethylene glycol dimethacrylate as crosslinker, with the aim to understand their influence on the efficiency of the MIP. The performance of each MIP was tested in batch experiments via their binding capacity. The MIP prepared in the presence of nickel ions in dimethylsulfoxide-acetonitrile mixture (P4) exhibited the highest binding capacity for neopterin (260 μmol per gram of polymer). A selectivity study with two other pteridines demonstrated the polymer P4 also to possess the best selectivity.

A molecularly imprinted polymer for the specific retention of neopterin was developed. A set of 6 polymers was prepared under different experimental condition. The performance of each MIP was tested through their binding capacity. The MIP P4 prepared in the presence of nickel ions exhibited the highest binding capacity

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Authors and Affiliations

  1. Department of Engineering for Innovation, University of Salento, via per Monteroni Km 1, 73100, Lecce, Italy

    Roberta Del Sole, Anna Scardino, Maria Rosaria Lazzoi, Lucia Mergola, Sonia Scorrano & Giuseppe Vasapollo

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  1. Roberta Del Sole
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  2. Anna Scardino
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  3. Maria Rosaria Lazzoi
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  4. Lucia Mergola
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  5. Sonia Scorrano
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  6. Giuseppe Vasapollo
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Correspondence to Roberta Del Sole.

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Del Sole, R., Scardino, A., Lazzoi, M.R. et al. A molecularly imprinted polymer for the determination of neopterin. Microchim Acta 180, 1401–1409 (2013). https://doi.org/10.1007/s00604-013-0982-y

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  • DOI: https://doi.org/10.1007/s00604-013-0982-y

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