Skip to main content
SpringerLink
Log in

Synthesis and characterization of gold nanocomposites with modified and intact polyamidoamine dendrimers

  • Original Paper
  • Published:
Microchimica Acta Aims and scope Submit manuscript

Abstract

Preparation and characterization of nanocomposites of gold nanoparticles (AuNPs) using 3rd and 4th generation of poly(amidoamine) dendrimers (PAMAM) and modified PAMAM were studied. By utilizing poly-(ethylene glycol) grafted PAMAM G3 (PEG-G3), 9.7 ± 3.1 nm gold particles were obtained; compared to particles of 15.4 ± 7.3 nm size stabilized by unmodified PAMAM G3 dendrimers. In order to decrease the size of the synthesized gold nanoparticles the quaternization of primary amines in the periphery of PAMAM G4 (QG4) dendrimer was suggested. Characterization of the structures by fluorescence spectroscopy, UV-Vis spectrometry and transmission electron microscopy (TEM) revealed that PEG-G3 was better than PAMAM G4 as a templating agent, and that the QG4 dendrimer produced gold nanoparticles with the smallest size and the lowest polydispersity. The average size of gold nanoparticles protected by PAMAM G4 and QG4 were 13.9 ± 4.5 and 6.1 ± 1.6 nm, respectively.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Bergamini G, Ceroni P, Balzani V, Gingras M, Raimundo JM, Morandi V, Merli PG (2007) Synthesis of small gold nanoparticles: Au(I) disproportionation catalyzed by a persulfurated coronene dendrimer. Chem Commun 40:4167–4169

    Article  Google Scholar 

  2. Nirmala Grace A, Pandian K (2006) One pot synthesis of polymer protected gold nanoparticles and nanoprisms in glycerol. Colloid Surface A 290:138–142

    Article  Google Scholar 

  3. Jansen JFGA, de Brabander-van den Berg EEM, Meijer EW (1994) Encapsulation of guest molecules into a dendritic box. Science 266:1226–1228

    Article  CAS  Google Scholar 

  4. Jansen JFGA, Meijer EW (1995) The dendritic box: shape-selective liberation of encapsulated guests. J Am Chem Soc 117:4417–4418

    Article  CAS  Google Scholar 

  5. Esumi K, Suzuki A, Aihara N, Usui K, Torigoe K (1998) Preparation of gold colloids with UV irradiation using dendrimers as stabilizer. Langmuir 14:3157–3159

    Article  CAS  Google Scholar 

  6. Tomalia DA, Baker H, Dewald JR, Hall M, Kallos G, Martin S, Roeck J, Ryder J, Smith P (1985) A new class of polymers: starburst-dendritic macromolecules. Polym J 17:117–132

    Article  CAS  Google Scholar 

  7. Tomalia DA, Baker H, Dewald JR, Hall M, Kallos G, Martin S, Roeck J, Ryder J, Smith P (1986) Dendritic macromolecules: synthesis of starburst dendrimers. Macromolecules 19:2466–2468

    Article  CAS  Google Scholar 

  8. Tomalia DA, Naylor AM, Goddard WA III (1990) Starburst dendrimers: molecular-level control of size, shape, surface chemistry, topology, and flexibility from atoms to macroscopic matter. Angew Chem Int Edn 29:138–175

    Article  Google Scholar 

  9. Balogh L, Tomalia DA (1998) Poly(Amidoamine) dendrimer-templated nanocomposites. 1. Synthesis of zerovalent copper nanoclusters. J Am Chem Soc 120:7355–7356

    Article  CAS  Google Scholar 

  10. Garcia ME, Baker LA, Crooks RM (1999) Preparation and characterization of dendrimer—gold colloid nanocomposites. Anal Chem 71:256–258

    Article  CAS  Google Scholar 

  11. Zhao M, Crooks RM (1999) Dendrimer-encapsulated Pt nanoparticles: synthesis,. characterization, and applications to catalysis. Adv Mater 11:217–220

    Article  CAS  Google Scholar 

  12. Bar G, Rubin S, Cutts RW, Taylor TN, Zawodzinski TA (1996) Dendrimer-modified silicon oxide surfaces as platforms for the deposition of gold and silver colloid monolayers: preparation method, characterization, and correlation between microstructure and optical properties. Langmuir 12:1172–1179

    Article  CAS  Google Scholar 

  13. Esumi K, Suzuki A, Yamahira A, Torigoe K (2000) Role of poly(amidoamine) dendrimers for preparing nanoparticles of gold, platinum, and silver. Langmuir 16:2604–2608

    Article  CAS  Google Scholar 

  14. Esumi K, Hosoya T, Suzuki A, Torigoe K (2000) Spontaneous formation of gold nanoparticles in aqueous solution of sugar persubstituted poly(amidoamine) dendrimers. Langmuir 16:2978–2980

    Article  CAS  Google Scholar 

  15. Grohn F, Kim G, Bauer BJ, Amis E (2001) Nanoparticle formation within dendrimer-containing polymer networks: route to new organic–inorganic hybrid materials. J Macromolecules 34:2179–2185

    Article  Google Scholar 

  16. Hedden RC, Bauer BJ, Paul Smith A, Groh F, Amis E (2002) Templating of inorganic nanoparticles by PAMAM/PEG dendrimer—star polymers. Polymer 43:5473–5481

    Article  CAS  Google Scholar 

  17. Nomani A R, Haririan I, Dinarvand R, Azizi E, Sarbolouki MN, Amini M, Gazori T, Barar J, Omidi Y (Submitted) Cellular delivery of nanostructured polyamidoamine dendrimers and establishment of a simple methodology upon ninhydrin reaction. Revised for J Bioact Compat Polym

  18. Zhao M, Crooks RM (1999) Dendrimer-encapsulated Pt nanoparticles: synthesis, characterization, and applications to catalysis. Adv Mater 11:217–220

    Article  CAS  Google Scholar 

  19. Niu Y, Yeung LK, Crooks RM (2001) Size-selective hydrogenation of olefins by dendrimer-encapsulated palladium nanoparticles. J Am Chem Soc 123:6840–6846

    Article  CAS  Google Scholar 

  20. Kim YG, Oh SK, Crooks RM (2004) Preparation and characterization of 1–2 nm dendrimer-encapsulated gold nanoparticles having very narrow size-distributions. Chem Mater 16:167–172

    Article  CAS  Google Scholar 

  21. Bielinska A, Eichman JD, Lee I, Baker JR, Balogh L Jr (2002) Imaging Au0-PAMAM gold-dendrimer nanocomposites in cells. J Nanopart Res 4:395–403

    Article  CAS  Google Scholar 

  22. Lechner MD (2005) Influence of Mie scattering on nanoparticles with different particle sizes and shapes: photometry and analytical ultracentrifugation with absorption optics. J Serb Chem Soc 70:361–369

    Article  CAS  Google Scholar 

  23. Mosseri S, Henglein A, Janata E (1989) Reduction of dicyanoaurate(I) in aqueous solution: formation of nonmetallic clusters and colloidal gold. J Phys Chem 93:6791–6795

    Article  CAS  Google Scholar 

  24. Tokuhisa H, Zhao M, Baker LA, Phan VT, Dermody DL, Garcia ME, Peez RF, Crooks RM, Mayer TM (1998) Preparation and characterization of dendrimer monolayers and dendrimer-alkanethiol mixed monolayers adsorbed to gold. J Am Chem Soc 120:4492–4501

    Article  CAS  Google Scholar 

  25. Jiang GH, Wang L, Chen T, Yu HJ, Chen C (2006) Preparation of gold nanoparticles in the presence of poly(benzyl ether) alcohol dendrons. Mater Chem Phys 98:76–82

    Article  CAS  Google Scholar 

  26. Hwu Y et al (2007) Aqueous gold nanosols stabilized by electrostatic protection generated by X-ray irradiation assisted radical reduction. Mater Chem Phys 106:323–329

    Article  Google Scholar 

  27. Huang L, Zhai M, Peng J, Xu L, Li J, Wei G (2007) Synthesis, size control and fluorescence studies of gold nanoparticles in carboxymethylated chitosan aqueous solutions. J Colloid Interf Sci 316:398–404

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Faculty of Chemistry, Tarbiat Moalem University, 49 Mofateh Avenue, P.O. Box 15815-3587, Tehran, Iran

    Faten Divsar & Marzieh Chaloosi

  2. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran, Iran

    Alireza Nomani & Ismaeil Haririan

  3. Department of Pharmaceutics, Faculty of Pharmacy, Zanjan University of Medical Sciences, P.O. Box 45139-56184, Zanjan, Iran

    Alireza Nomani

Authors
  1. Faten Divsar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alireza Nomani
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Marzieh Chaloosi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ismaeil Haririan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Marzieh Chaloosi.

Additional information

Faten Divsar and Alireza Nomani are equally contributed to this article.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Divsar, F., Nomani, A., Chaloosi, M. et al. Synthesis and characterization of gold nanocomposites with modified and intact polyamidoamine dendrimers. Microchim Acta 165, 421–426 (2009). https://doi.org/10.1007/s00604-009-0156-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00604-009-0156-0

Keywords

Search

Navigation