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The neutrophil: one of the cellular targets of interleukin-10

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  • Published:
International Journal of Clinical and Laboratory Research

Abstract

Interleukin-10 exerts a wide spectrum of in vitro and in vivo biological activities implicated in the regulation of the inflammatory and immune responses. Among the different cell types affected by interleukin-10, monocyte/macrophages and lymphocytes appear to be particularly modified with regard to their function, morphology, and phenotype. However, recent studies performed in our laboratory, as well as by other groups, suggest that a number of functional activities of polymorphonuclear neutrophils are also subject to regulation by interleukin-10. In view of the central role of polymorphonuclear neutrophils in host defense processes and in amplifying inflammatory and immune reactions, the ability of interleukin-10 to act as a potent modulator of this cell type opens new perspectives as to the potential therapeutic utility of interleukin-10. This article reviews what is currently known about the effects of interleukin-10 on neutrophils.

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References

  1. Moore KW, O’Garra A, Waal Malefijit R de, Vieira P, Mosmann TR. Interleukin-10. Annu Rev Immunol 1993; 11: 165.

    Article  PubMed  CAS  Google Scholar 

  2. Mosmann TR. Properties and functions of interleukin-10. Adv Immunol 1994; 56: 1.

    Article  PubMed  CAS  Google Scholar 

  3. Geissler K. Current status of clinical development of interleukin-10. Curr Opin Hematol 1996; 3: 203.

    PubMed  CAS  Google Scholar 

  4. Takanaski S, Nonaka R, Xing Z, O’Byrne P, Dolovich J, Jordana M. Interleukin-10 inhibits lipopolysaccharide-induced survival and cytokine production by human peripheral blood eosinophils. J Exp Med 1994; 180: 711.

    Article  PubMed  CAS  Google Scholar 

  5. Pretolani M, Goldman M. IL-10: a potential therapy for allergic inflammation? Immunol Today 1997; 18: 277.

    Article  PubMed  CAS  Google Scholar 

  6. Smith JA. Neutrophils, host defense, and inflammation: a double-edged sword. J Leukoc Biol 1994; 56: 672.

    PubMed  CAS  Google Scholar 

  7. Weiss SJ. Tissue destruction by neutrophils. N Engl J Med 1989; 320: 365.

    PubMed  CAS  Google Scholar 

  8. Cassatella MA. The production of cytokines by polymorphonuclear neutrophils. Immunol Today 1995; 16: 21.

    Article  PubMed  CAS  Google Scholar 

  9. Cassatella MA. Cytokines produced by polymorphonuclear neutrophils. Molecular and biological aspects. Berlin Heidelberg New York: Springer, 1996.

    Google Scholar 

  10. Cassatella MA, Meda L, Bonora S, Ceska M, Constantin G. Interleukin-10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1β in mediating the production of IL-8 triggered by lipopolysaccharide. J Exp Med 1993; 178: 2207.

    Article  PubMed  CAS  Google Scholar 

  11. Kasama T, Strieter RM, Lukacs NW, Burdick MD, Kunkel SL. Regulation of neutrophil-derived chemokine expression by IL-10. J Immunol 1994; 152: 3559.

    PubMed  CAS  Google Scholar 

  12. Donnelly RP, Freeman SL, Hayes MP. Inhibition of IL-10 expression by IFNγ upregulates transcription of TNFα in human monocytes. J Immunol 1995; 155: 1420.

    PubMed  CAS  Google Scholar 

  13. Bogdan C, Paik J, Vodovotz Y, Nathan C. Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-beta and interleukin-10. J Biol Chem 1992; 267: 23301.

    PubMed  CAS  Google Scholar 

  14. Cavaillon JM, Marie C, Pitton C. Regulation of neutrophil derived IL-8 production by anti-inflammatory cytokines (IL-4, IL-10 and TGFβ). Proceedings of the 3rd International Congress on the Immune Consequences of Trauma Shock and Sepsis. Munich: Pabst Science Publishers, 1996.

    Google Scholar 

  15. Cassatella MA, Guasparri I, Ceska M, Bazzoni F, Rossi F. Interferon-γ inhibits IL-8 production by human polymorphonuclear leucocytes. Immunology 1993; 78: 177.

    PubMed  CAS  Google Scholar 

  16. Meda L, Gasperini S, Ceska M, Cassatella MA. Modulation of proinflammatory cytokine release from human polymorphonuclear leukocytes by IFNγ. Cell Immunol 1994; 157: 448.

    Article  PubMed  CAS  Google Scholar 

  17. Kasama T, Strieter RM, Lukacs NW, Lincoln PM, Burdick MD, Kunkel SL. IFNγ modulates the expression of neutrophil-derived chemokines. J Invest Med 1995; 43: 58.

    CAS  Google Scholar 

  18. Retini C, Vecchiarelli A, Monari C, Tascini C, Bistoni F, Kozel TR. Capsular polysaccharide ofCryptococcus neoformans induces proinflammatory cytokine release by human neutrophils. Infect Immun 1996; 64: 2897.

    PubMed  CAS  Google Scholar 

  19. Pang G, Ortega M, Zighang R, Reeves G, Clancy R. Autocrine modulation of IL-8 production by sputum neutrophils in chronic bronchial sepsis. Am J Respir Crit Care Med 1997; 155: 726.

    PubMed  CAS  Google Scholar 

  20. Cassatella MA, Gasperini S, Calzetti F, McDonald PP, Trinchieri G. Lipopolysaccharide-induced interleukin-8 gene expression in human granulocytes: transcriptional inhibition by interferon-gamma. Biochem J 1995; 310: 751.

    PubMed  CAS  Google Scholar 

  21. Cassatella MA, Meda L, Gasperini S, Calzetti F, Bonora S. IL-10 upregulates IL-1 receptor antagonist production from lipopolysaccharide-stimulated human polymorphonuclear leukocytes by delaying mRNA degradation. J Exp Med 1994; 179; 1695.

    Article  PubMed  CAS  Google Scholar 

  22. Wang P, Wu P, Anthes JC, Siegel MI, Egan RW, Billah MM. Interleukin-10 inhibits interleukin-8 production in human neutrophils. Blood 1994; 83: 2678.

    PubMed  CAS  Google Scholar 

  23. Torosantucci A, Chiani P, Quinti I, Ausiello CM, Mezzaroma I, Cassone A. Responsiveness of human polymorphonuclear cells (PMNL) to stimulation by a mannoprotein fraction (MP-F2) ofCandida albicans; enhanced production of IL-6 and TNFα by MP-F2-stimulated PMNL from HIV-infected subjects. Clin Exp Immunol 1997; 107: 451.

    Article  PubMed  CAS  Google Scholar 

  24. DeForge LE, Tracey DE, Kenney JS, Remick DG. Interleukin-1 receptor antagonist protein inhibits interleukin-8 expression in lipopolysaccharide-stimulated human whole blood. Am J Pathol 1992; 140: 1045.

    PubMed  CAS  Google Scholar 

  25. Porat B, Poutsiaka DD, Miller LC, Granowitz EV, Dinarello CA. IL-1 receptor blockade reduces endotoxin andBorrelia burgdorferi-stimulated IL-8 synthesis in human mononuclear cells. FASEB J 1992; 6: 2482.

    PubMed  CAS  Google Scholar 

  26. Tilg H, Shapiro L, Atkins MB, Dinarello CA, Mier JW. Induction of circulating and erythrocyte-bound IL-8 by IL-2 immunotherapy and suppression of its in vitro production by IL-1 receptor antagonist and soluble tumor necrosis factor receptor (p75) chimera. J Immunol 1993; 151: 3299.

    PubMed  CAS  Google Scholar 

  27. Poll T van der, Calvano SE, Kumar A, Braxton CC, Coyle SM, Barbosa K, Moldawer LL, Lowry SF. Endotoxin induces downregulation of tumor necrosis factor receptors on circulating monocytes and granulocytes in humans. Blood 1995; 86: 2754.

    PubMed  Google Scholar 

  28. Orlando S, Matteucci C, Fadlon EJ, Buurman WA, Bardella MT, Colotta F, Introna M, Mantovani A, TNFα, unlike other pro- and anti-inflammatory cytokines, induces rapid release of the IL-1 type II decoy receptor in human myelomocytic cells. J Immunol 1997; 158: 3861.

    PubMed  CAS  Google Scholar 

  29. Jenkins JK, Malyak M, Arend WP. The effects of interleukin-10 on interleukin-1 receptor antagonist and interleukin-1β production in human monocytes and neutrophils. Lymphokine Cytokine Res 1994; 13: 47.

    PubMed  CAS  Google Scholar 

  30. Marie C, Pitton C, Fitting C, Cavaillon JM. IL-10 and IL-4 synergize with TNFα to induce IL-1ra production by human neutrophils. Cytokine 1996; 8: 147.

    Article  PubMed  CAS  Google Scholar 

  31. Re F, Mengozzi M, Muzio M, Dinarello CA, Mantovani A, Colotta F. Expression of interleukin-1 receptor antagonist (IL-1ra) by human circulating polymorphonuclear cells. Eur J Immunol 1993; 23: 570.

    Article  PubMed  CAS  Google Scholar 

  32. McColl SR, Paquin R, Menard C, Beaulieu AD. Human neutrophils produce high levels of the interleukin-1 receptor antagonist in response to granulocyte/macrophage colony-stimulating factor and tumor necrosis factor alpha. J Exp Med 1992; 176: 593.

    Article  PubMed  CAS  Google Scholar 

  33. Cassatella MA. Interferon-γ inhibits the lipopolysaccharide-induced macrophage inflammatory protein-1α gene transcription in human neutrophils. Immunol Lett 1996; 49: 79.

    Article  PubMed  CAS  Google Scholar 

  34. Gasperini S, Calzetti F, Russo MP, De Gironcoli M, Cassatella MA. Regulation of GROα production in human granulocytes. J Inflamm 1995; 45: 143.

    PubMed  CAS  Google Scholar 

  35. Cassatella MA, Meda L, Gasperini S, D’Andrea A, Ma X, Trinchieri G. Interleukin-12 production by human polymorphonuclear leukocytes. Eur J Immunol 1995; 25: 1.

    Article  PubMed  CAS  Google Scholar 

  36. Trinchieri G. Interleukin-12: a cytokine at the interface of inflammation and immunity. Adv Immunol. In press.

  37. Cassatella MA, Gasperini S, Calzetti F, Bertagnin A, Luste AD, McDonald PP. Regulated production of the interferon-gamma-inducible protein-10 (IP-10) chemokine by human neutrophils. Eur J Immunol 1997; 27: 111.

    Article  PubMed  CAS  Google Scholar 

  38. Farber JM. Mig and IP-10: CXC chemokines that target lymphocytes. J Leukoc Biol 1997; 6: 246.

    Google Scholar 

  39. Loetscher P, Uguccioni M, Bordoli L, Baggiolini M, Moser B, Chizzolini C, Dayer JM. CCR5 is characteristic of Th1 lymphocytes. Nature 1998; 391: 344.

    Article  PubMed  CAS  Google Scholar 

  40. Gerard C, Bruyns C, Marchant A, Abramowicz D, Vandenabeele P, Delvaux A, Fiers W, Goldman M, Velu T. Interleukin-10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. J Exp Med 1993; 177: 547.

    Article  PubMed  CAS  Google Scholar 

  41. Howard M, Muchamuel T, Andrade S, Menon S. Interleukin-10 protects mice from lethal endotoxemia. J Exp Med 1993; 177: 1205.

    Article  PubMed  CAS  Google Scholar 

  42. Standiford TJ, Strieter RM, Lukacs W, et al. Neutralization of IL-10 increases lethality in endotoxemia. Cooperative effects of macrophage inflammatory protein-2 and tumor necrosis factor. J Immunol 1995; 155: 2222.

    PubMed  CAS  Google Scholar 

  43. Vassalli P. The pathophysiology of tumor necrosis factors. Annu Rev Immunol 1992; 10: 411.

    Article  PubMed  CAS  Google Scholar 

  44. Ohlsson K, Bjork P, Bergenfeldt M, et al. An interleukin 1 receptor antagonist reduces mortality in endotoxin shock. Nature 1990; 348: 550.

    Article  PubMed  CAS  Google Scholar 

  45. Davies P, MacIntyre DE. Prostaglandins and inflammation. In: Gallin JI, Goldstein IM, Snyderman RM, eds. Inflammation. Basic principles and clinical correlates. New York: Raven; 1992:123–138.

    Google Scholar 

  46. Jouzeau JY, Terlain B, Abid A, Nedelec E, Netter P. Cyclooxygenase isoenzymes. How recent findings affect thinking about nonsteroidal anti-inflammatory drugs. Drugs 1997; 53: 563.

    PubMed  CAS  Google Scholar 

  47. Tomlinson A, Appleton I, Moore AR, Gilroy DW, Willis D, Mitchell JA, Willoughby DA. Cyclo-oxygenase and nitric oxide synthase isoforms in rat carrageenin-induced pleurisy. Br J Pharmacol 1994; 113: 693.

    PubMed  CAS  Google Scholar 

  48. Niiro H, Otsuka T, Izuhara K, Yamaoka K, Ohshima K, Tanabe T, Hara S, Nemoto Y, Tanaka Y, Nakashima H, Niho Y. Regulation by interleukin-10 and interleukin-4 of cyclooxygenase-2 expression in human neutrophils. Blood 1997; 89: 1621.

    PubMed  CAS  Google Scholar 

  49. Herrmann F, Lindemann A, Gauss J, Mertelsmann R. Cytokine-stimulation of prostaglandin synthesis from endogenous and exogenous arachidonic acids in polymorphonuclear leukocytes involving activation and new synthesis of cyclooxygenase. Eur J Immunol 1990; 20: 2513.

    Article  PubMed  CAS  Google Scholar 

  50. Weithmann KU, Jeske S, Schlotte V. Effect of leflunomide on constitutive and inducible pathways of cellular eicosanoid generation. Agents Actions 1994; 41: 164.

    Article  PubMed  CAS  Google Scholar 

  51. Ayala A, Chaudry IH. Platelet activating factor and its role in trauma, shock, and sepsis. New Horiz 1996; 4: 265.

    PubMed  CAS  Google Scholar 

  52. Anderson BO, Bensard DD, Harken AH. The role of platelet activating factor and its antagonists in shock, sepsis and multiple organ failure. Surg Gynecol Obstet 1991; 172: 415.

    PubMed  CAS  Google Scholar 

  53. Bussolati B, Mariano F, Montrucchio G, Piccoli G, Camussi G. Modulatory effect of interleukin-10 on the production of platelet let-activating factor and superoxide anions by human leucocytes. Immunology 1997; 90: 440.

    Article  PubMed  CAS  Google Scholar 

  54. Gegner JA, Ulevitch RJ, Tobias PS. Lipopolysaccharide (LPS) signal transduction and clearance. Dual roles for LPS binding protein and membrane CD14. J Biol Chem 1995; 270: 5320.

    Article  PubMed  CAS  Google Scholar 

  55. Bussolino F, Sironi M, Bocchietto E, Mantovani A. Synthesis of platelet-activating factor by polymorphonuclear neutrophils stimulated with interleukin-8. J Biol Chem 1992; 267: 14598.

    PubMed  CAS  Google Scholar 

  56. Kitchen E, Rossi AG, Condliffe AM, Haslett C, Chilvers ER. Demonstration of reversible priming of human neutrophils using platelet-activating factor. Blood 1996; 88: 4330.

    PubMed  CAS  Google Scholar 

  57. DeLeo FR, Quinn MT. Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteins. Leukoc Biol 1996; 60: 677.

    Google Scholar 

  58. Cassatella MA, Bazzoni F, Aste Amezaga M, Rossi F. Studies on the gene expression of several NADPH oxidase components. Biochem Soc Trans 1991; 19: 63.

    PubMed  CAS  Google Scholar 

  59. Capsoni F, Minonzio F, Ongari AM, Carbonelli V, Galli A, Zanussi C. Interleukin-10 down-regulates oxidative metabolism and antibody-dependent cellular cytotoxicity of human neutrophils. Scand J Immunol 1997; 45: 269.

    Article  PubMed  CAS  Google Scholar 

  60. Bovolenta C, Gasperini S, McDonald PP, Cassatella MA. High affinity receptor for IgG (FcγRI/CD64) gene and STAT protein binding to the IFNγ response region (GRR) are regulated differently in human neutrophils and monocytes by IL-10. J Immunol 1998; 160: 911.

    PubMed  CAS  Google Scholar 

  61. Chaves MM, Silvestrini AA, Silva-Teixeira DN, Nogueira-Machado JA. Effect in vitro of gamma interferon and interleukin-10 on generation of oxidizing species by human granulocytes. Inflamm Res 1996; 45: 313.

    Article  PubMed  CAS  Google Scholar 

  62. Chaves MM, Novato-Silva E, Gomez MV, Lima-e-Silva FC, Nogueira-Machado JA. Effect of gamma interferon and interleukin-10 on phosphoinositol turnover by human neutrophils in vitro. Braz J Med Biol Res 1996; 29: 1389.

    PubMed  CAS  Google Scholar 

  63. Laichalk LL, Danforth JM, Standiford TJ. Interleukin-10 inhibits neutrophil phagocytic and bactericidal activity. FEMS Immunol Med Microbiol 1996; 15: 181.

    Article  PubMed  CAS  Google Scholar 

  64. Cassatella MA, Bazzoni F, Flynn RM, Dusi S, Trinchieri G, Rossi F. Molecular basis of IFN-γ and lipopolysaccharide enhancement of phagocyte respiratory burst capability. Studies on the gene expression of several NADPH oxidase components. J Biol Chem 1990; 265: 20241.

    PubMed  CAS  Google Scholar 

  65. Kuga S, Otsuka T, Niiro H, Nunoi H, Nemoto Y, Nakano T, Ogo T, Umei T, Niho Y. Suppression of superoxide anion production by IL-10 is accompanied by a downregulation of the genes for subunit proteins of NADPH oxidase. Exp Hematol 1996; 24: 151.

    PubMed  CAS  Google Scholar 

  66. Tascini C, Baldelli F, Monari C, Retini C, Pietrella D, Francisci D, Bistoni F, Vecchiarelli A. Inhibition of fungicidal activity of polymorphonuclear leukocytes from HIV-infected patients by interleukin (IL)-4 and IL-10. AIDS 1996; 10: 477.

    Article  PubMed  CAS  Google Scholar 

  67. Haslett C. Granulocyte apoptosis and inflammatory disease. Br Med Bull 1997; 53: 669.

    PubMed  CAS  Google Scholar 

  68. Homburg CH, Roos D. Apoptosis of neutrophils. Curr Opin Hematol 1996; 3: 94.

    Article  PubMed  CAS  Google Scholar 

  69. Keel M, Ungethum U, Steckholzer U, Niederer E, Hartung T, Trentz O, Ertel W. Interleukin-10 counterregulates proinflammatory cytokine-induced inhibition of neutrophil apoptosis during severe sepsis. Blood 1997; 90: 3356.

    PubMed  CAS  Google Scholar 

  70. Blackwell TS, Christman JW. Sepsis and cytokines: current status. Br J Anaesth 1996; 77: 110.

    PubMed  CAS  Google Scholar 

  71. Colotta F, Re F, Polentarutti N, Sozzani S, Mantovani A. Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products. Blood 1992; 80: 2012.

    PubMed  CAS  Google Scholar 

  72. Gasperini S, Donini M, Dusi S, Cassatella MA. Interleukin-10 decreases tyrosine phosphorylation of discrete lipopolysaccharide-induced phosphoproteins in human granulocytes. Biochem Biophys Res Commun 1995; 209: 87.

    Article  PubMed  CAS  Google Scholar 

  73. Yousefi S, Green DR, Blaser K, Simon HU. Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils. Proc Natl Acad Sci USA 1994; 91: 10868.

    Article  PubMed  CAS  Google Scholar 

  74. Yousefi S, Hoessli DC, Blaser K, Mills GB, Simon HU. Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils. J Exp Med 1996; 183: 1407.

    Article  PubMed  CAS  Google Scholar 

  75. Ward C, Murray J, Bruce L, Farrow S, Chilvers ER, Hannah S, Haslett C, Rossi AG. Interleukin-10 does not directly affect the constitutive rate of human neutrophil or eosinophil apoptosis. Biochem Soc Trans 1997; 25: 245S.

  76. Cox G. IL-10 enhances resolution of pulmonary inflammation in vivo by promoting apoptosis of neutrophils. Am J Physiol 1996; 271: L566.

    Google Scholar 

  77. Estaquier J, Ameisen JC. A role for T-helper type-1 and type-2 cytokines in the regulation of human monocyte apoptosis. Blood 1997; 90: 1618.

    PubMed  CAS  Google Scholar 

  78. Ulich TR, Watson LR, Yin SM, Guo KZ, Wang P, Thang H, Castillo J del. The intratracheal administration of endotoxin and cytokines. I. Characterization of LPS-induced IL-1 and TNF mRNA expression and the LPS-, IL-1-, and TNF-induced inflammatory infiltrate. Am J Pathol 1991; 138: 1485.

    PubMed  CAS  Google Scholar 

  79. Cox G, Crossley J, Xing Z. Macrophage engulfment of apoptotic neutrophils contributes to the resolution of acute pulmonary inflammation in vivo. Am J Respir Cell Mol Biol 1995; 12: 232.

    PubMed  CAS  Google Scholar 

  80. Cassatella MA, Cappelli R, Della Bianca V, Grzeskowiak M, Dusi S, Berton G. Interferon-γ activates human neutrophil oxygen metabolism and exocytosis. Immunology 1988; 63: 499.

    PubMed  CAS  Google Scholar 

  81. Heijnen IA, Van de Winkel JG. A human FcγRI/CD64 transgenic model for in vivo analysis of (bispecific) antibody therapeutics. J Hematother 1995; 4: 351–356.

    PubMed  CAS  Google Scholar 

  82. Ravetch JV. Fc receptors. Curr Opin Immunol 1997; 9: 121.

    Article  PubMed  CAS  Google Scholar 

  83. Perussia B, Dayton F, Lazarus R, Fanning V, Trinchieri G. Immune interferon induces the receptor for monomeric IgG1 on human monocytic and myeloid cells. J Exp Med 1983; 158: 1092.

    Article  PubMed  CAS  Google Scholar 

  84. Guyre PM, Morganelli PM, Miller R. Recombinant immune interferon increases immunoglobulin G Fc receptors on cultured human mononuclear phagocytes. J Clin Invest 1983; 72: 393.

    Article  PubMed  CAS  Google Scholar 

  85. Aste Amezaga M, Bazzoni F, Sorio C, Rossi F, Cassatella MA. Evidence for the involvement of distinct signal transduction pathways in the regulation of constitutive and interferon-γ-dependent gene expression of NADPH oxidase components (gp91-phox, p47-phox, and p22-phox) and high-affinity receptor for IgG (FcγR-I) in human polymorphonuclear leukocytes. Blood 1992; 79: 735.

    Google Scholar 

  86. Huizinga TJW, Van der Schoot CE, Roos D, Weering RS. Induction of neutrophil Fc-γ receptor I expression can be used as marker for biologic activity of human recombinant interferon-γ in vivo. Blood 1991; 77: 2088.

    PubMed  CAS  Google Scholar 

  87. Gericke GH, Ericson SG, Pan L, Mills LE, Guyre PM, Ely P. Mature polymorphonuclear leukocytes express high-affinity receptors for FcγR-I after stimulation with granulocyte colony stimulating factor (G-CSF). J Leukoc Biol 1995; 57: 455.

    PubMed  CAS  Google Scholar 

  88. Te Velde AA, Waal Malefijit R de, Huijens RJF, Vries JE de, Figdor CG. IL-10 stimulates monocytes FcγR surface expression and cytotoxic activity: distinct regulation of antibody dependent cellular cytotoxicity by IFNγ, IL-4, and IL-10. J Immunol 1992; 149: 4048.

    PubMed  CAS  Google Scholar 

  89. Lehmann J, Seegert D, Strehlow I, Schindler C, Lohmann-Matthes ML, Decker T. IL-10-induced factors belonging to the p91 family of proteins bind to IFNγresponsive promoter elements. J Immunol 1994; 153: 165.

    PubMed  CAS  Google Scholar 

  90. Heijnen IAFM, Vug MJ van, Fanger NA, Graziano RF, Wit TPM de, Hofhuis FMA, Guyre PM, Capel PJA, Verbeek JS, Winkel JGJ van de. Antigen targeting to myeloid-specific human FcγR-I/CD64 triggers enhanced antibody responses in transgenic mice. J Clin Invest 1996; 97: 331.

    Article  PubMed  CAS  Google Scholar 

  91. Schindler C, Darnell JE Jr. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem 1995; 64: 621.

    Article  PubMed  CAS  Google Scholar 

  92. Pearse RN, Feinman R, Ravetch JV. Characterization of the promoter of the human gene encoding the high affinity IgG receptor: transcriptional induction byγ-interferon is mediated through common DNA response elements. Proc Natl Acad Sci USA 1991; 88: 11305.

    Article  PubMed  CAS  Google Scholar 

  93. Larner AC, David M, Feldman GM, Igarashi K, Hackett RH, Webb DSA, Sweitzer SM, Petricoin EF III, Finbloom DS. Tyrosine phosphorylation of DNA binding proteins by multiple cytokines. Science 1993; 261: 1730.

    Article  PubMed  CAS  Google Scholar 

  94. Finbloom DS, Winestock KD. IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1α and STAT3 complexes in human T cells and monocytes. J Immunol 1995; 155: 1079.

    PubMed  CAS  Google Scholar 

  95. Ho AS, Wei SH, Mui AL, Miyajima A, Moore KW. Functional regions of the mouse interleukin-10 receptor cytoplasmic domain. Mol Cell Biol 1995; 15: 5043.

    PubMed  CAS  Google Scholar 

  96. Cassatella MA, Bazzoni F, Calzetti F, Guasparri I, Rossi F, Trinchieri G. Interferon-γ transcriptionally modulates the expression of the genes for the high affinity IgG-Fc receptor and the 47-kDa cytosolic component of NADPH oxidase in human polymorphonuclear leukocytes. J Biol Chem 1991; 266: 22079.

    PubMed  CAS  Google Scholar 

  97. Bovolenta C, Gasperini S, Cassatella MA. Granulocyte colony-stimulating factor induces the binding of STAT1 and STAT3 to the IFNγ response region within the promoter of the FcγRI/CD64 gene in human neutrophils. FEBS Lett 1996; 386: 239.

    Article  PubMed  CAS  Google Scholar 

  98. Lutfalla G, Gardiner K, Uze G. A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR. Genomics 1993; 16: 366.

    Article  PubMed  CAS  Google Scholar 

  99. Kotenko SV, Krause CD, Izotova LS, Pollack BP, Wu W, Pestka S. Identification and functional characterization of a second chain of the interleukin-10 receptor complex. EMBO J 1997; 16: 5894.

    Article  PubMed  CAS  Google Scholar 

  100. Meraz MA, White JM, Sheehan KCF, Bach EA, Rodig SJ, Dighe AS, Kaplan DH, Riley JK, Greenlund AC, Campbell D, Carver-Moore K, DuBois RN, Clark R, Aguet M, Schreiber M. Targeted disruption of the STAT1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 1996; 84: 431.

    Article  PubMed  CAS  Google Scholar 

  101. O’Farrell AM, Liu Y, Moore KW, Mui ALF. IL-10 inhibits macrophage activition and proliferation by distinct signaling mechanisms: evidence for STAT3-dependent and -independent pathways. EMBO J. In Press.

  102. Zuany-Amorim C, Haile S, Leduc D, Dumarey C, Huerre M, Vargaftig BB, Pretolani M. Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice. J Clin Invest 1995; 95: 2644.

    Article  PubMed  CAS  Google Scholar 

  103. Shanley TP, Schmal H, Friedl HP, Jones ML, Ward PA. Regulatory effects of intrinsic IL-10 in IgG immune complex-induced lung injury. J Immunol 1995; 154: 3454.

    PubMed  CAS  Google Scholar 

  104. Shanley TP, Peters JL, Jones ML, Chensue SW, Kunkel SL, Ward PA. Regulatory effects of endogenous interleukin-1 receptor antagonist protein in immunoglobulin G immune complex-induced lung injury. J Clin Invest 1996; 97: 963.

    Article  PubMed  CAS  Google Scholar 

  105. Hess PJ, Seeger JM, Huber TS, Welborn MB, Martin TD, Harward TR, Duschek S, Edwards PD, Solorzano CC, Copeland EM, Moldawer LL. Exogenously administered interleukin-10 decreases pulmonary neutrophil infiltration in a tumor necrosis factor-dependent murine model of acute visceral ischemia. J Vasc Surg 1997; 26: 113.

    Article  PubMed  CAS  Google Scholar 

  106. Lane JS, Todd KE, Lewis MP, Gloor B, Ashley SW, Reber HA, McFadden DW, Chandler CF. Interleukin-10 reduces the systemic inflammatory response in a murine model of intestinal ischemia/reperfusion. Surgery 1997; 122: 288.

    Article  PubMed  CAS  Google Scholar 

  107. Engles RE, Huber TS, Zander DS, Hess PJ, Welborn MB, Moldawer LL, Seeger JM. Exogenous human recombinant interleukin-10 attenuates hindlimb ischemia-reperfusion injury. Surg Res 1997; 69: 425.

    Article  CAS  Google Scholar 

  108. Rogy MA, Auffemberg T, Espat NJ, Philip R, Remick D, Wollenberg GK, Copeland EM III, Moldawer LL. Human TNF receptor (p55) and IL-10 gene transfer in the mouse reduces mortality to lethal endotoxemia. J Exp Med 1995; 181: 2289.

    Article  PubMed  CAS  Google Scholar 

  109. Perretti M, Szabo C, Thiemermann C. Effect of interleukin-4 and IL-10 on leucocyte migration and nitric oxide production in the mouse. Br J Pharmacol 1995; 116: 2251.

    PubMed  CAS  Google Scholar 

  110. Kubes P, Kanwar S, Niu XF, Gaboury JP. Nitric oxide synthesis inhibition induces leukocyte adhesion via superoxide and mast cells. FASEB J 1993; 7: 1293.

    PubMed  CAS  Google Scholar 

  111. Nill MR, Oberyszyn TM, Ross MS, Oberyszyn AS, Robertson FM. Temporal sequence of pulmonary cytokine gene expression in response to endotoxin in C3H/Hen endotoxin-sensitive and C3H/HeJ endotoxin resistant mice. J Leukoc Biol 1995; 58: 563.

    PubMed  CAS  Google Scholar 

  112. Romani L, Mencacci A, Cenci E, Del Sero G, Bistoni F, Puccetti P. An immunoregulatory role for neutrophils in CD4+ T helper subset selection in mice with candidiasis. J Immunol 1997; 158: 2356.

    PubMed  CAS  Google Scholar 

  113. Romani L, Mencacci A, Cenci E, Spaccapelo R, Del Sero G, Nicoletti I, Trinchieri G, Bistoni F, Puccetti P. Neutrophil production of IL-12 and IL-10 in candidiasis and efficacy of IL-12 therapy in neutropenic mice. J Immunol 1997; 158: 5349.

    PubMed  CAS  Google Scholar 

  114. Greenberger MJ, Strieter RM, Kunkel SL, Danforth JM, Goodman RE, Standiford TJ. Neutralization of IL-10 increases survival in a murine model ofKlebsiella pneumonia. J Immunol 1995; 155: 722.

    PubMed  CAS  Google Scholar 

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  1. Department of Pathology, Section of General Pathology, University of Verona, Strada le Grazie 4, I-37134, Verona, Italy

    M. A. Cassatella

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  1. M. A. Cassatella
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Cassatella, M.A. The neutrophil: one of the cellular targets of interleukin-10. Int J Clin Lab Res 28, 148–161 (1998). https://doi.org/10.1007/s005990050036

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  • DOI: https://doi.org/10.1007/s005990050036

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