Skip to main content

Advertisement

SpringerLink
Log in

Co-occurrence of mucoepidermoid carcinoma and squamous cell carcinoma of the esophagus: Report of a case

  • Case Reports
  • Published:
Surgery Today Aims and scope Submit manuscript

Abstract

A case of co-occurrence of a mucoepidermoid carcinoma (MEC) and a squamous cell carcinoma (SCC) in the esophagus is described. The present patient was a 61-year-old man who underwent a curative esophagectomy with a regional lymph node dissection for a MEC in the lower esophagus and a SCC near the esophagogastric junction. The two lesions were endoscopically and histologically divided by a normal esophageal mucosa. The MEC of the esophagus consisted of SCC cells and signet-ring cells, and a mucin product and carcinoembryonic antigen, which were found at high levels in the blood serum before surgery, were detected histochemically in the signet-ring cells. The follow-up survey of the patients with esophageal MEC previously reported in Japan showed that most of the patients died of either local recurrence or widespread metastasis after treatment; the overall 5-year survival rate was 24.4% in the total 25 cases, and 27.7% in the 22 resected cases. However, 6 patients who died of therapeutic complications were included among these patients; furthermore, the 5-year survival rate after surgery was 29.2% in the patients treated over the last decade (1989–1998). We expect that the clinical outcome of patients treated for esophageal MEC will therefore improve in the future.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Suzuki H, Nagayo T (1980) Primary tumors of the esophagus other than squamous cell carcinoma: histologic classification and statistics in the surgical and autopsied materials in Japan. Int Adv Surg Oncol 3:73–109

    PubMed  CAS  Google Scholar 

  2. Kasai M, Shimamura N (1967) Primary adenoacanthoma and adenocarcinoma of the middle thoracic esophagus (in Japanese). Jpn J Cancer Clin 13:700–704

    CAS  Google Scholar 

  3. Toriie S, Takeda S, Kohli Y, Tanaka T, Kodama M, Kawai K (1976) A case of mucoepidermoid carcinoma of esophagus (in Japanese with English abstract). Gan no Rinsho (Jpn J Cancer Clin) 22:606–610

    Google Scholar 

  4. Osamura Y, Sato S, Miwa M, Miwa T (1978) Mucoepidermoid carcinoma of the esophagus. Am J Gastroenterol 69:467–470

    PubMed  CAS  Google Scholar 

  5. Kato H, Iizuka T, Watanabe H, Hirata K, Saito T, Hirashima T, Hirota T, Itabashi M (1980) Primary adenocarcinoma of the esophagus. Report of six cases (in Japanese with English abstract). Gan no Rinsho (Jpn J Clin Oncol) 10:301–310

    Google Scholar 

  6. Emoto I, Chihara T, Tamai M, Yoshida H, Kobayashi M, Okano M, Goto H, Okuda S, Tani S (1982) A patient with double carcinoma of the esophagus — squamous cell carcinoma and mucoepidermoid carcinoma (in Japanese with English abstract). Gan no Rinsho (Jpn J Cancer Clin) 28:1754–1757

    Google Scholar 

  7. Matsufuji H, Kuwano H, Ueo H, Sugimachi K, Inokuchi K (1985) Mucoepidermoid carcinoma of the esophagus: a case report. Jpn J Surg 15:55–59

    Article  PubMed  CAS  Google Scholar 

  8. Motojima T, Nabeya K, Fukuzumi N (1985) A case of esophageal collision tumor with multicentric mucoepidermoid carcinomas and squamous cell carcinoma (in Japanese with English abstract). Kyorin Igakukai Zasshi (J Kyorin Med Soc) 16:397–404

    Google Scholar 

  9. Umegae S, Mori T, Tonouchi H, Kihata T, Yoshino J, Nagata N (1987) A case of primary mucoepidermoid carcinoma of the esophagus (in Japanese). Nihon Shokakigeka Gakkaizasshi (Jpn J Gastroenterol Surg) 20:2201–2204

    Google Scholar 

  10. Takubo K, Takai A, Yamashita K, Onda M (1987) Carcinoma with signet ring cells of the esophagus. Acta Pathol Jpn 37:989–995

    PubMed  CAS  Google Scholar 

  11. Kanazawa N, Nakata Y, Kubota A, Mori Y, Terauchi K, Ichii S (1989) A case of esophageal mucoepidermoid carcinoma — histopathological comparison with normal esophageal tissue (in Japanese with English abstract). Hyogo Ikadaigakukaisi (Acta Med Hyogo) 14:195–210

    Google Scholar 

  12. Ozawa S, Ando N, Shinozawa Y, Ohmori T, Kase K, Sato T, Abe O (1989) Two cases of resected esophageal mucoepidermoid carcinoma. Jpn J Surg 19:86–92

    Article  PubMed  CAS  Google Scholar 

  13. Otagaki S, Takiyama W, Aogi K, Murakami M, Takashima S (1989) A case of early esophageal cancer diagnosed as mucoepidermoid carcinoma (in Japanese). Nihon Shokakigeka Gakkaizasshi (Jpn J Gastroenterol Surg) 22:2677–2680

    Google Scholar 

  14. Ohno K, Takubo K (1989) Primary mucoepidermoid carcinoma of the esophagus: a case report (in Japanese). Nihon Rinsho Saibou Gakkaizasshi (J Jpn Soc Clin Cytol) 28:420–424

    Google Scholar 

  15. Sasajima K, Watanabe M, Takubo K, Takai A, Yamashita K, Onda M (1990) Mucoepidermoid carcinoma of the esophagus: report of two cases and review of the Literature. Endoscopy 20:140–143

    Article  Google Scholar 

  16. Tin M, Wagai K, Endo W, Odaka Y, Shouji M, Nakahachi S, Ishii T, Igarashi M, Asakura T, Hoshida T (1993) Mucoepidermoid cancer of the esophagus (in Japanese). Kesennuma Igakuzasshi (Kesennuma J Med) 4:54–57

    Google Scholar 

  17. Yokoo H, Honnma M, Hamada K, Nakazato Y (1994) Report of an unoperated autopsy case of mucoepidermoid carcinoma of the esophagus (in Japanese with English abstract). Byori to Rinsho (Pathol Clin Med) 12:481–485

    Google Scholar 

  18. Mafune K, Takubo K, Tanaka Y, Fujita K (1995) Sclerosing mucoepidermoid carcinoma of the esophagus with intraepithelial carcinoma or dysplastic epithelium. J Surg Oncol 58:184–190

    Article  PubMed  CAS  Google Scholar 

  19. Nishimaki T, Tanaka O, Suzuki T, Aizawa K, Watanabe K, Nakagawa S, Hatakeyama K, Watanabe H (1996) Barrett’s esophagus associated with mucoepidermoid carcinoma arizing in the esophageal squamous epithelium. Acta Med Biol 44:51–57

    Google Scholar 

  20. Murakami M, Shimizu Y, Kameyama H, Fukoe Y, Kameyama S, Kusano M (1998) Report of a case of mucoepidermoid carcinoma of the esophagus. Dig Endosc 10:51–54

    Article  Google Scholar 

  21. Azzopardi JG, Menzie T (1962) Primary oesophageal adenocarcinoma: confirmation of its existence by the finding of mucus gland tumours. Br J Surg 49:497–506

    Article  PubMed  CAS  Google Scholar 

  22. Kay S (1968) Mucoepidermoid carcinoma of the esophagus. Cancer 22:1053–1059

    Article  PubMed  CAS  Google Scholar 

  23. Pascal RR, Clearfield HR (1987) Mucoepidermoid (adenosquamous) carcinoma arising in Barrett’s esophagus. Dig Dis Sci 32:428–432

    Article  PubMed  CAS  Google Scholar 

  24. Turnbull AD, Rosen P, Goodner JT, Beattie EJ (1973) Primary malignant tumors of the esophagus other than typical epidermoid carcinoma. Ann Thorac Surg 15:463–473

    Article  PubMed  CAS  Google Scholar 

  25. Lam KY, Dickens P, Loke SL, Ma L, Wong J (1994) Squamous cell carcinoma of the oesophagus with mucin-secreting component (muco-epidermoid carcinoma and adenosquamous carcinoma): a clinicopathologic study and a review of literature. Eur J Surg Oncol 20:25–31

    PubMed  CAS  Google Scholar 

  26. Sekiguchi H, Akiyama S, Fujiwara M, Nakamura H, Kondo K, Kasai Y, Ito K, Sakamoto J, Takagi H (1999) Phase II trial of 5-fluorouracil and low-dose cisplatin in patients with squamous cell carcinoma of the esophagus. Surg Today 29:97–101

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Second Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan

    Naohiko Koide, Kazutoshi Hamanaka, Jun Igarashi, Kazuhiro Hanazaki, Wataru Adachi & Jun Amano

  2. Second Department of Internal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan

    Shigetoshi Hosaka

  3. Clinical Laboratory Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan

    Takeshi Uehara

Authors
  1. Naohiko Koide
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kazutoshi Hamanaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jun Igarashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kazuhiro Hanazaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Wataru Adachi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Shigetoshi Hosaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Takeshi Uehara
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Jun Amano
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Koide, N., Hamanaka, K., Igarashi, J. et al. Co-occurrence of mucoepidermoid carcinoma and squamous cell carcinoma of the esophagus: Report of a case. Surg Today 30, 636–642 (2000). https://doi.org/10.1007/s005950070104

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s005950070104

Key Words

Search

Navigation