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E-PASS scoring system serves as a predictor of short- and long-term outcomes in gastric cancer surgery

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Abstract

Purposes

This study aimed to evaluate the estimation of the physiological ability and surgical stress (E-PASS) scoring system for predicting the short- and long-term outcomes in gastric cancer (GC) surgery.

Methods

We analyzed a multi-institutional dataset to study patients who underwent gastrectomy with a curative intent between 2010 and 2014. This study evaluated the associations between the optimal E-PASS score cutoff value and the following outcomes: (1) the incidence of postoperative complications in stage I–III GC patients and (2) the prognosis in stage II–III GC patients.

Results

A total of 2495 GC patients were included. A cutoff value of 0.419 was determined using the ROC curve analysis. Postoperative complications were observed more frequently in the E-PASS-high group than that in the E-PASS-low group (30% vs. 17%, p < 0.0001). Among pStage II–III GC patients (n = 1009), the overall survival time of the E-PASS-high group was significantly shorter than that of the E-PASS-low group (hazard ratio 2.08; 95% confidence interval 1.64–2.65; p < 0.0001). A forest plot revealed that E-PASS-high was associated with a greater prognostic factor for overall survival in most subgroups.

Conclusions

The E-PASS scoring system may therefore be a useful predictor of the short- and long-term outcomes in patients with GC who have undergone radical gastrectomy.

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Acknowledgements

We would like to thank Editage (http://www.editage.com) for the English language editing.

Funding

There is no funding to de disclosed.

Author information

Authors and Affiliations

  1. Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, 466-8550, Japan

    Koki Nakanishi, Mitsuro Kanda, Daisuke Kobayashi, Dai Shimizu, Chie Tanaka, Michitaka Fujiwara & Yasuhiro Kodera

  2. Department of Gastroenterological Surgery, Aichi Cancer Center, Nagoya, Japan

    Seiji Ito

  3. Department of Surgery, Komaki City Hospital, Komaki, Japan

    Yoshinari Mochizuki & Daisuke Kobayashi

  4. Department of Surgery, Yokkaichi Municipal Hospital, Yokkaichi, Japan

    Hitoshi Teramoto

  5. Department of Surgery, Konan Kosei Hospital, Konan, Japan

    Kiyoshi Ishigure

  6. Department of Surgery, Ichinomiya Municipal Hospital, Ichinomiya, Japan

    Toshifumi Murai

  7. Department of Surgery, Gifu Prefectural Tajimi Hospital, Tajimi, Japan

    Takahiro Asada

  8. Department of Surgery, Okazaki City Hospital, Okazaki, Japan

    Akiharu Ishiyama

  9. Department of Surgery, Tosei General Hospital, Seto, Japan

    Hidenobu Matsushita

  10. Department of Medical Equipment and Supplies Management, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Michitaka Fujiwara

  11. Biostatistics Center, Graduate School of Medicine, Kurume University, Kurume, Japan

    Kenta Murotani

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  1. Koki Nakanishi
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  2. Mitsuro Kanda
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  3. Seiji Ito
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  15. Kenta Murotani
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  16. Yasuhiro Kodera
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Corresponding author

Correspondence to Mitsuro Kanda.

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Ethical approval

All procedures performed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions.

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Supplementary Information

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Supplementary file1 (DOCX 23 kb)

595_2021_2394_MOESM2_ESM.tif

Supplementary file2. Supplemental Figure 1. Overall survival curves according to the pathological disease stage. A pStage I, B pStage II, and C pStage III. (TIF 927 kb)

595_2021_2394_MOESM3_ESM.tif

Supplementary file3. Supplemental Figure 2. Disease-free survival curves according to pathological disease stage. A pStage I, B pStage II, and C pStage III. (TIF 916 kb)

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Nakanishi, K., Kanda, M., Ito, S. et al. E-PASS scoring system serves as a predictor of short- and long-term outcomes in gastric cancer surgery. Surg Today 52, 914–922 (2022). https://doi.org/10.1007/s00595-021-02394-3

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  • DOI: https://doi.org/10.1007/s00595-021-02394-3

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