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Adverse oncological outcome of surgical site infection after liver resection for colorectal liver metastases

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Abstract

Purposes

Postoperative complications are associated with poor overall and cancer-specific survival after resection of various types of cancer, including primary colorectal cancer. However, the oncological impact of surgical site infection (SSI) after liver resection for colorectal liver metastases (CLM) is unclear. The aim of this study was to investigate the oncological impact of SSI after liver resection for CLM.

Methods

We reviewed data from 367 consecutive patients treated by curative liver resection for CLM between 1994 and 2015. Patients who underwent simultaneous resection of colorectal cancer and synchronous liver metastases (n = 86) were excluded from the analysis. Short- and long-term outcomes were analyzed.

Results

SSI developed in 18 (6.4%) of the 281 patients in the analytic cohort (SSI group). The remaining 93.6% (n = 263) did not suffer this complication (no-SSI group). The operative duration was significantly longer in the SSI group than in the No-SSI group (p = 0.002). The overall survival rates 5 years after liver resection for CLM were 33.3% in the SSI group vs. 50.7% in the No-SSI group (p = 0.043). Multivariate analysis indicated that a liver tumor size ≥ 5 cm, R1 resection, and SSI were independently associated with overall survival after liver resection.

Conclusions

SSI after liver resection for CLM is associated with adverse oncological outcomes.

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Authors and Affiliations

  1. Department of Surgery, Ogaki Municipal Hospital, 4-86 Minaminokawa-cho, Ogaki, Gifu, 503-8502, Japan

    Yasuyuki Fukami, Atsuyuki Maeda, Yuichi Takayama, Takamasa Takahashi, Masahito Uji & Yuji Kaneoka

Authors
  1. Yasuyuki Fukami
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  2. Atsuyuki Maeda
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  3. Yuichi Takayama
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  4. Takamasa Takahashi
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Correspondence to Yasuyuki Fukami.

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Fukami, Y., Maeda, A., Takayama, Y. et al. Adverse oncological outcome of surgical site infection after liver resection for colorectal liver metastases. Surg Today 49, 170–175 (2019). https://doi.org/10.1007/s00595-018-1715-y

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  • DOI: https://doi.org/10.1007/s00595-018-1715-y

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