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Childbirth after surgery for familial adenomatous polyposis in Japan

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Abstract

Purpose

Familial adenomatous polyposis (FAP) is a genetic disorder. Some female patients with FAP can become pregnant. However, the current state of childbirth after surgery for FAP is unclear in Japan.

Methods

The study investigated 303 patients (147 female) who had undergone surgery for FAP at the 23 institutions between 2000 and 2012.

Results

Eighty female patients had information available on childbirth after surgery for FAP. Eight patients (10 %) gave birth after surgery. The mean age at surgery for FAP was 27 (range 20–41) years and 37 years in patients with and without childbirth after surgery, respectively (P = 0.044). The rate of childbirth after surgery was 17 % in women ≤30 years of age and 13 % in those ≤40 years of age. Although only one patient with invasive cancer (2.9 %) gave childbirth after surgery, seven patients without cancer (15.6 %) gave birth (P = 0.045).

Conclusions

This study clarified the current state of childbirth after surgery for FAP in Japan. It is important to use these data to determine the best therapeutic approach for female FAP patients.

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Acknowledgments

The authors would like to acknowledge all of the patients and their families. In addition to the investigators in the author list, we acknowledge the following investigators who also participated in this study: Koji Komori, Department of Gastroenterological Surgery Aichi Cancer Center Hospital, Aichi; Kenjiro Kotake, Department of Surgery, Tochigi Cancer Center, Tochigi; Takeshi Nagasaka, Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Hirotoshi Hasegawa, Department of Surgery, Keio University School of Medicine, Tokyo; Motoi Koyama, Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine, Aomori; Yoshito Akagi, Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka; Toshimasa Yatsuoka, Department of Gastroenterological Surgery, Saitama Cancer Center, Saitama; Masataka Ikeda, Department of Surgery, National Hospital Organization, Osaka National Hospital, Osaka; Kensuke Kumamoto, Department of Organ Regulatory Surgery, Fukushima Medical University School of Medicine, Fukushima; Kiyotaka Kurachi, Department of Surgery 2, Hamamatsu University School of Medicine, Shizuoka; Kohji Tanakaya, Department of Surgery, Iwakuni Clinical Center, Yamaguchi; Kazuhiko Yoshimatsu, Department of Surgery, Tokyo Women’s Medical University Medical Center East, Tokyo. This study was supported in part by a Grant-in-aid for Cancer Research from the Ministry of Health, Labor and Welfare, and by the Japanese Society for Cancer of the Colon and Rectum.

Author information

Authors and Affiliations

  1. Department of Surgery, Tokyo Metropolitan Hiroo Hospital, 2-34-10 Ebisu, Shibuya-ku, Tokyo, 150-0013, Japan

    Hirotoshi Kobayashi

  2. Study Group for Familial Adenomatous Polyposis (FAP) in the Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan

    Hirotoshi Kobayashi, Hideyuki Ishida, Hideki Ueno, Takao Hinoi, Yasuhiro Inoue, Fumio Ishida, Yukihide Kanemitsu, Tsuyoshi Konishi, Tatsuro Yamaguchi, Naohiro Tomita, Nagahide Matsubara, Toshiaki Watanabe & Kenichi Sugihara

  3. Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan

    Hideyuki Ishida

  4. Department of Surgery, National Defense Medical College, Saitama, Japan

    Hideki Ueno

  5. Department of Surgery and Institute for Clinical Research, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Hiroshima, Japan

    Takao Hinoi

  6. Department of Gastrointestinal and Pediatric Surgery, Mie University, Graduate School of Medicine, Mie, Japan

    Yasuhiro Inoue

  7. Digestive Disease Center, Northern Yokohama Hospital, Showa University, Yokohama, Japan

    Fumio Ishida

  8. Colorectal Surgery Division, National Cancer Center Hospital, Tokyo, Japan

    Yukihide Kanemitsu

  9. Department of Gastroenterological Surgery, Gastroenterological Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan

    Tsuyoshi Konishi

  10. Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan

    Tatsuro Yamaguchi

  11. Department of Surgery, Hyogo College of Medicine, Hyogo, Japan

    Naohiro Tomita & Nagahide Matsubara

  12. Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

    Toshiaki Watanabe

  13. Tokyo Medical and Dental University, Tokyo, Japan

    Kenichi Sugihara

Authors
  1. Hirotoshi Kobayashi
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  2. Hideyuki Ishida
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  3. Hideki Ueno
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  4. Takao Hinoi
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  5. Yasuhiro Inoue
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  6. Fumio Ishida
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  7. Yukihide Kanemitsu
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  8. Tsuyoshi Konishi
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  9. Tatsuro Yamaguchi
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  10. Naohiro Tomita
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  11. Nagahide Matsubara
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  12. Toshiaki Watanabe
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  13. Kenichi Sugihara
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Corresponding author

Correspondence to Hirotoshi Kobayashi.

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Conflict of interest

Hirotoshi Kobayashi and the other co-authors have no conflicts of interest.

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Kobayashi, H., Ishida, H., Ueno, H. et al. Childbirth after surgery for familial adenomatous polyposis in Japan. Surg Today 47, 233–237 (2017). https://doi.org/10.1007/s00595-016-1374-9

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  • DOI: https://doi.org/10.1007/s00595-016-1374-9

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