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Prognostic indicators based on inflammatory and nutritional factors after pancreaticoduodenectomy for pancreatic cancer

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Abstract

Purpose

We evaluated prognostic indicators based on inflammatory and nutritional factors, namely, the modified Glasgow Prognostic Score (mGPS), the Prognostic Nutritional Index (PNI), the neutrophil/lymphocyte ratio (NLR), and the platelet/lymphocyte ratio (PLR), to determine their efficiency and significance after pancreaticoduodenectomy for pancreatic cancer.

Methods

The subjects of this study were 46 patients who underwent pancreaticoduodenectomy for pancreatic cancer between October 2007 and December 2014. Patients were divided into preoperative mGPS (0/1 and 2), PNI (<40 and ≥40), NLR (<2.5 and ≥2.5), and PLR (<200 and ≥200) groups, to evaluate various perioperative outcomes.

Results

Hemoglobin concentrations were significantly lower (P = 0.019), whereas intra-abdominal bleeding was significantly higher (P = 0.040) in the PNI (<40) group than in the PNI (≥40) group. The incidence of postoperative pneumonia was significantly higher in the mGPS (2) group (P = 0.009), and surgical complications greater than grade 3 (Clavien–Dindo classification) were significantly increased in the NLR (≥2.5) group (P = 0.041). Overall survival rates in the PNI (<40) (P = 0.019), NLR (≥2.5) (P = 0.001), and PLR (≥200) (P < 0.001) groups were significantly lower than those in the other groups. The PLR was the only independent prognostic indicator (P = 0.002) according to multivariate analysis.

Conclusions

The mGPS, PNI, and NLR were effective predictive indicators of postoperative complications. The PLR was the most useful prognostic indicator for pancreatic cancer patients after pancreaticoduodenectomy.

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Acknowledgments

We thank Professor Yoichi Kurosawa of the Tottori University Division of Health Administration and Promotion for his advice on statistical analysis.

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Authors and Affiliations

  1. Division of Surgical Oncology, Department of Surgery, Tottori University Hospital, 36-1 Nishi-cho, Yonago, Tottori, 683-8504, Japan

    Joji Watanabe, Shinji Otani, Teruhisa Sakamoto, Yosuke Arai, Takehiko Hanaki, Masataka Amisaki, Naruo Tokuyasu, Soichiro Honjo & Masahide Ikeguchi

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  1. Joji Watanabe
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  2. Shinji Otani
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Correspondence to Joji Watanabe.

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Watanabe, J., Otani, S., Sakamoto, T. et al. Prognostic indicators based on inflammatory and nutritional factors after pancreaticoduodenectomy for pancreatic cancer. Surg Today 46, 1258–1267 (2016). https://doi.org/10.1007/s00595-016-1308-6

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