Abstract
Purpose
To compare the short- and intermediate-term outcomes of open versus laparoscopic abdominoperineal resection (APR) for low rectal cancer.
Methods
Elective open and laparoscopic APRs were identified in a prospective database and were 1:1 propensity score-matched for age, ASA grade, tumour stage and type of neoadjuvant therapy. The short- and intermediate-term outcomes were compared.
Results
From January 2003 until June 2013, a total of 135 APRs (87 open, 48 laparoscopic) were identified and matched (n = 96, standardised mean difference of covariates <0.25). The thirty-day mortality, R0 rate, lymph nodes harvested and reoperations were similar. The length of the hospital stay was shorter in the laparoscopic group [10 versus 14 days, p = 0.004 (Mann–Whitney U test), Bonferroni-corrected significance level = 0.0083]. The median follow-up was 4.6 (IQR: 2.0–6.0) years. The overall and recurrence-free 3-year survival rate estimates (Kaplan–Meier method; 95 % CI in brackets) were 71 % (59–86) and 57 % (44–73) in the open group versus 78 % (66–92) and 72 % (60–87) in the laparoscopic group, respectively [p = 0.167 and p = 0.186 (log-rank test), respectively]. The 3-year cumulative incidence of recurrence was 27 % (15–40) in the open group and 16 % (8–29) in the laparoscopic group [p = 0.359 (Gray’s test)].
Conclusions
Compared to open APR, laparoscopic APR provided a shorter length of hospital stay while showing no intermediate-term differences in the survival or cumulative incidence of recurrence.
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References
Wu JS, Birnbaum EH, Fleshman JW. Early experience with laparoscopic abdominoperineal resection. Surg Endosc. 1997;11(5):449–55.
Vennix S, Pelzers L, Bouvy N, Beets GL, Pierie JP, Wiggers T, et al. Laparoscopic versus open total mesorectal excision for rectal cancer. Cochrane Database Syst Rev 2014; 4: CD005200.
Ahmad NZ, Racheva G, Elmusharaf H. A systematic review and meta-analysis of randomized and non-randomized studies comparing laparoscopic and open abdominoperineal resection for rectal cancer. Colorectal Dis. 2013;15(3):269–77.
Inada R, Yamamoto S, Oshiro T, Takawa M, Fujita S, Akasu T. Case-matched comparison of the short-term outcomes between laparoscopic and open abdominoperineal resection for rectal cancer. Surg Today. 2014;44(4):640–5.
Coleman MG, Hanna GB, Kennedy R. The national training programme for laparoscopic colorectal surgery in England: a new training paradigm. Colorectal Dis. 2011;13(6):614–6.
Kehlet H. Fast-track colorectal surgery. Lancet. 2008;371(9615):791–3.
Fiore JF Jr, Bialocerkowski A, Browning L, Faragher IG, Denehy L. Criteria to determine readiness for hospital discharge following colorectal surgery: an international consensus using the Delphi technique. Dis Colon Rectum. 2012;55(4):416–23.
Marsh PJ, James RD, Schofield PF. Definition of local recurrence after surgery for rectal carcinoma. Br J Surg. 1995;82(4):465–8.
Stelzner S, Koehler C, Stelzer J, Sims A, Witzigmann H. Extended abdominoperineal excision vs. standard abdominoperineal excision in rectal cancer—a systematic overview. Int J Colorectal Dis. 2011;26(10):1227–40.
Stuart EA. Matching methods for causal inference: a review and a look forward. Stat Sci. 2010;25(1):1–21.
Iacus SM, King G, Porro G. Multivariate matching methods that are monotonic imbalance bounding. J Am Stat Assoc. 2011;106(493):345–61.
Altman DG, De Stavola BL, Love SB, Stepniewska KA. Review of survival analyses published in cancer journals. Br J Cancer. 1995;72(2):511–8.
Gray R. A class of K-sample tests for comparing cumulative incidence of a competing risk. Ann Stat. 1988;16:1141–54.
Bland JM, Altman DG. Survival probabilities (the Kaplan-Meier method). BMJ. 1998;317(7172):1572.
Inada R, Yamamoto S, Oshiro T, Takawa M, Fujita S, Akasu T. A case-matched comparison of the short-term outcomes between laparoscopic and open abdominoperineal resection for rectal cancer. Surg Today 2013.
Boutros M, Hippalgaonkar N, Silva E, Allende D, Wexner SD, Berho M. Laparoscopic resection of rectal cancer results in higher lymph node yield and better short-term outcomes than open surgery: a large single-center comparative study. Dis Colon Rectum. 2013;56(6):679–88.
Yang Z, Xu H, Zhang W, Xu Y, Xu Z. A retrospective analysis of ultralow anterior resection vs. abdomino-perineal resection for lower rectal cancer. Hepatogastroenterology 2012; 59(118): 1780–3.
Jefferies MT, Evans MD, Hilton J, Chandrasekaran TV, Beynon J, Khot U. Oncological outcome after laparoscopic abdominoperineal excision of the rectum. Colorectal Dis. 2012;14(8):967–71.
Ramos JR, Petrosemolo RH, Valory EA, Polania FC, Pecanha R. Abdominoperineal resection: laparoscopic versus conventional. Surg Laparosc Endosc. 1997;7(2):148–52.
Baker RP, White EE, Titu L, Duthie GS, Lee PW, Monson JR. Does laparoscopic abdominoperineal resection of the rectum compromise long-term survival? Dis Colon Rectum. 2002;45(11):1481–5.
Araujo SE, da Silva eSousa AH Jr, de Campos FG, Habr-Gama A, Dumarco RB, Caravatto PP, et al. Conventional approach x laparoscopic abdominoperineal resection for rectal cancer treatment after neoadjuvant chemoradiation: results of a prospective randomized trial. Rev Hosp Clin Fac Med Sao Paulo. 2003;58(3):133–40.
Vlug MS, Wind J, Hollmann MW, Ubbink DT, Cense HA, Engel AF, et al. Laparoscopy in combination with fast track multimodal management is the best perioperative strategy in patients undergoing colonic surgery: a randomized clinical trial (LAFA-study). Ann Surg. 2011;254(6):868–75.
Aziz O, Constantinides V, Tekkis PP, Athanasiou T, Purkayastha S, Paraskeva P, et al. Laparoscopic versus open surgery for rectal cancer: a meta-analysis. Ann Surg Oncol. 2006;13(3):413–24.
Ng SS, Leung KL, Lee JF, Yiu RY, Li JC, Teoh AY, et al. Laparoscopic-assisted versus open abdominoperineal resection for low rectal cancer: a prospective randomized trial. Ann Surg Oncol. 2008;15(9):2418–25.
Stewart DB, Hollenbeak C, Boltz M. Laparoscopic and open abdominoperineal resection for cancer: how patient selection and complications differ by approach. J Gastrointest Surg. 2011;15(11):1928–38.
Guillou PJ, Quirke P, Thorpe H, Walker J, Jayne DG, Smith AM, et al. Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial. Lancet. 2005;365(9472):1718–26.
Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205–13.
McDonald JR, Renehan AG, O’Dwyer ST, Haboubi NY. Lymph node harvest in colon and rectal cancer: current considerations. World J Gastrointest Surg. 2012;4(1):9–19.
den Dulk M, Marijnen CA, Putter H, Rutten HJ, Beets GL, Wiggers T, et al. Risk factors for adverse outcome in patients with rectal cancer treated with an abdominoperineal resection in the total mesorectal excision trial. Ann Surg. 2007;246(1):83–90.
Sebag-Montefiore D, Stephens RJ, Steele R, Monson J, Grieve R, Khanna S, et al. Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial. Lancet. 2009;373(9666):811–20.
Bernstein TE, Endreseth BH, Romundstad P, Wibe A. Improved local control of rectal cancer reduces distant metastases. Colorectal Dis. 2012;14(10):e668–78.
Numata M, Hasuo K, Hara K, Maezawa Y, Kazama K, Inari H, et al. A propensity score-matching analysis comparing the oncological outcomes of laparoscopic and open surgery in patients with Stage I/II colon and upper rectal cancers. Surg Today. 2015;45(6):700–7.
Garcia-Granero E, Faiz O, Munoz E, Flor B, Navarro S, Faus C, et al. Macroscopic assessment of mesorectal excision in rectal cancer: a useful tool for improving quality control in a multidisciplinary team. Cancer. 2009;115(15):3400–11.
Zhao JK, Chen NZ, Zheng JB, He S, Sun XJ. Laparoscopic versus open surgery for rectal cancer: results of a systematic review and meta-analysis on clinical efficacy. Mol Clin Oncol. 2014;2(6):1097–102.
Sadahiro S, Suzuki T, Ishikawa K, Nakamura T, Tanaka Y, Masuda T, et al. Recurrence patterns after curative resection of colorectal cancer in patients followed for a minimum of ten years. Hepatogastroenterology. 2003;50(53):1362–6.
Raftopoulos I, Reed JF 3rd, Bergamaschi R. Circumferential resection margin involvement after laparoscopic abdominoperineal excision for rectal cancer. Colorectal Dis. 2012;14(4):431–7.
Habr-Gama A, Perez RO, Nadalin W, Sabbaga J, Ribeiro U, Jr., Silva e Sousa AH, Jr., et al. Operative versus nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy: long-term results. Ann Surg 2004; 240(4):711–7 (discussion 7–8).
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The authors thank Sarah Marley for her support in reviewing and providing statistical advice on this manuscript.
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Odermatt, M., Flashman, K., Khan, J. et al. Laparoscopic-assisted abdominoperineal resection for low rectal cancer provides a shorter length of hospital stay while not affecting the recurrence or survival: a propensity score-matched analysis. Surg Today 46, 798–806 (2016). https://doi.org/10.1007/s00595-015-1244-x
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DOI: https://doi.org/10.1007/s00595-015-1244-x