Abstract
Purpose
Hypocalcemia after total thyroidectomy is a concern for every endocrine surgeon. We conducted this study to establish the value of the macroscopic appearance of preserved parathyroid glands after thyroidectomy in predicting post-thyroidectomy hypocalcemia.
Methods
In 2009, 237 patients underwent total thyroidectomy at our hospital. The macroscopic appearance of the preserved parathyroid glands was recorded and the serum calcium and intact parathyroid hormone levels were measured postoperatively.
Results
Thirteen patients (5.5 %) had transient hypocalcemia and 1 patient (0.4 %) had permanent hypocalcemia. All of the hypocalcemia patients with more than one normal preserved parathyroid had asymptomatic transient hypocalcemia that did not require medication. The sensitivity, specificity, positive predictive value, and negative predictive value for hypocalcemia with at least 1 normal preserved parathyroid were 78.6, 79.4, 19.3, and 98.3 %, respectively.
Conclusion
The macroscopic appearance of preserved parathyroid glands and the number of well-preserved parathyroid glands after thyroidectomy proved effective in predicting post-thyroidectomy hypocalcemia.
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References
Thomusch O, Machens A, Sekulla C, Ukkat J, Brauckhoff M, Dralle H. The impact of surgical technique on postoperative hypoparathyroidism in bilateral thyroid surgery: a multivariate analysis of 5846 consecutive patients. Surgery. 2003;133:180–5.
Cheah WK, Arici C, Ituarte PH, Siperstein AE, Duh QY, Clark OH. Complications of neck dissection for thyroid cancer. World J Surg. 2002;26:1013–6.
Toniato A, Boschin IM, Piotto A, Pelizzo M, Sartori P. Thyroidectomy and parathyroid hormone: tracing hypocalcemia-prone patients. Am J Surg. 2008;196:285–8.
Marohn MR, LaCivita KA. Evaluation of total/near-total thyroidectomy in a short-stay hospitalization: safe and cost-effective. Surgery. 1995;118:943–7 (discussion 7–8).
Bentrem DJ, Rademaker A, Angelos P. Evaluation of serum calcium levels in predicting hypoparathyroidism after total/near-total thyroidectomy or parathyroidectomy. Am Surg. 2001;67:249–51 (discussion 51–2).
Luu Q, Andersen PE, Adams J, Wax MK, Cohen JI. The predictive value of perioperative calcium levels after thyroid/parathyroid surgery. Head Neck. 2002;24:63–7.
Lindblom P, Westerdahl J, Bergenfelz A. Low parathyroid hormone levels after thyroid surgery: a feasible predictor of hypocalcemia. Surgery. 2002;131:515–20.
Lo CY, Luk JM, Tam SC. Applicability of intraoperative parathyroid hormone assay during thyroidectomy. Ann Surg. 2002;236:564–9.
Richards ML, Bingener-Casey J, Pierce D, Strodel WE, Sirinek KR. Intraoperative parathyroid hormone assay: an accurate predictor of symptomatic hypocalcemia following thyroidectomy. Arch Surg. 2003;138:632–5 (discussion 5–6).
Higgins KM, Mandell DL, Govindaraj S, Genden EM, Mechanick JI, Bergman DA, et al. The role of intraoperative rapid parathyroid hormone monitoring for predicting thyroidectomy-related hypocalcemia. Arch Otolaryngol Head Neck Surg. 2004;130:63–7.
McLeod IK, Arciero C, Noordzij JP, Stojadinovic A, Peoples G, Melder PC, et al. The use of rapid parathyroid hormone assay in predicting postoperative hypocalcemia after total or completion thyroidectomy. Thyroid. 2006;16:259–65.
Lam A, Kerr PD. Parathyroid hormone: an early predictor of postthyroidectomy hypocalcemia. Laryngoscope. 2003;113:2196–200.
Lombardi CP, Raffaelli M, Princi P, Santini S, Boscherini M, De Crea C, et al. Early prediction of postthyroidectomy hypocalcemia by one single iPTH measurement. Surgery. 2004;136:1236–41.
Asari R, Passler C, Kaczirek K, Scheuba C, Niederle B. Hypoparathyroidism after total thyroidectomy: a prospective study. Arch Surg. 2008;143:132–7 (discussion 8).
Fahad Al-Dhahri S, Al-Ghonaim YA, Sulieman Terkawi A. Accuracy of postthyroidectomy parathyroid hormone and corrected calcium levels as early predictors of clinical hypocalcemia. J Otolaryngol Head Neck Surg. 2010;39:342–8.
Cahill RA, Harty R, Cotter S, Watson RG. Parathormone response to thyroid surgery. Am J Surg. 2006;191:453–9.
Noordzij JP, Lee SL, Bernet VJ, Payne RJ, Cohen SM, McLeod IK, et al. Early prediction of hypocalcemia after thyroidectomy using parathyroid hormone: an analysis of pooled individual patient data from nine observational studies. J Am Coll Surg. 2007;205:748–54.
Moore FD Jr. Oral calcium supplements to enhance early hospital discharge after bilateral surgical treatment of the thyroid gland or exploration of the parathyroid glands. J Am Coll Surg. 1994;178:11–6.
Wang TS, Roman SA, Sosa JA. Postoperative calcium supplementation in patients undergoing thyroidectomy. Curr Opin Oncol. 2012;24:22–8.
Hong SJ, Choi PW, Shong YK, Ahn IM, Gong GY, Park KC. Parathyroid glands location, vascular supply and preservation during a total thyroidectomy. J Korean Surg Soc. 1999;57:820–7.
Del Rio P, Arcuri MF, Ferreri G, Sommaruga L, Sianesi M. The utility of serum PTH assessment 24 hours after total thyroidectomy. Otolaryngol Head Neck Surg. 2005;132:584–6.
Kirkby-Bott J, Markogiannakis H, Skandarajah A, Cowan M, Fleming B, Palazzo F. Preoperative vitamin D deficiency predicts postoperative hypocalcemia after total thyroidectomy. World J Surg. 2011;35:324–30.
Ander S, Johansson K, Smeds S. In situ preservation of the parathyroid glands during operations on the Thyroid. Eur J Surg. 1997;163:33–7.
Bergamaschi R, Becouarn G, Ronceray J, Arnaud JP. Morbidity of thyroid surgery. Am J Surg. 1998;176:71–5.
Glinoer D, Andry G, Chantrain G, Samil N. Clinical aspects of early and late hypocalcaemia afterthyroid surgery. Eur J Surg Oncol. 2000;26:571–7.
Kihara M, Yokomise H, Miyauchi A, Matsusaka K. Recovery of parathyroid function after total thyroidectomy. Surg Today. 2000;30:333–8.
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Sung, TY., Lee, Ym., Yoon, J.H. et al. Importance of the intraoperative appearance of preserved parathyroid glands after total thyroidectomy. Surg Today 46, 356–362 (2016). https://doi.org/10.1007/s00595-015-1216-1
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DOI: https://doi.org/10.1007/s00595-015-1216-1