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Limited resections for duodenal gastrointestinal stromal tumors and their oncologic outcomes

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Abstract

Purpose

Limited resection is considered a treatment option for duodenal gastrointestinal stromal tumors (GISTs) whenever technically feasible, but the optimal technique for this is still not well defined. We present the various types of limited resections for duodenal GISTs and analyze their postoperative outcomes.

Methods

The subjects of this retrospective clinicopathologic analysis were 21 patients who underwent limited resections for duodenal GIST between May, 2001 and June, 2014. The median follow-up period was 52 months (range 5–125 months).

Results

The patients comprised 12 men and 9 women, with a median age of 59 years (range 45–75 years), all of whom were treated by various forms of limited resection with clear margins. There were ten wedge resections with primary closure (eight open/two laparoscopic), two wedge resections with Roux-en Y duodenojejunostomy, three segmental duodenectomies with end-to-end duodenoduodenostomy, and six segmental duodenectomies with end-to-end duodenojejunostomy. Hepatic metastasis was found 27 months after surgery in one patient, who was given imatinib mesylate for 17 months to slow disease progression. The other 20 patients were alive and recurrence free at the time of writing.

Conclusion

Excellent recurrence-free survival was achieved after limited resections, supporting the consideration of various methods of limited resection as the treatment of choice for duodenal GISTs.

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Acknowledgments

This work was supported by the Soonchunhyang University Research Fund.

Conflict of interest

Jun Chul Chung, Hyung Chul Kim, and Sung Mo Hur have no conflicts of interest.

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Authors and Affiliations

  1. Department of Surgery, Soonchunhyang University College of Medicine, Soonchunhyang University Bucheon Hospital, 170 Jomaru-ro, Wonmi-gu, Bucheon, 420-767, Gyeonggi, South Korea

    Jun Chul Chung, Hyung Chul Kim & Sung Mo Hur

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  1. Jun Chul Chung
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  2. Hyung Chul Kim
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Correspondence to Jun Chul Chung.

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Chung, J.C., Kim, H.C. & Hur, S.M. Limited resections for duodenal gastrointestinal stromal tumors and their oncologic outcomes. Surg Today 46, 110–116 (2016). https://doi.org/10.1007/s00595-015-1163-x

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  • DOI: https://doi.org/10.1007/s00595-015-1163-x

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