Skip to main content
SpringerLink
Log in

Impact of cardiopulmonary complications of lung cancer surgery on long-term outcomes

  • Original Article
  • Published:
Surgery Today Aims and scope Submit manuscript

Abstract

Purpose

The impact of postoperative cardiopulmonary complications on long-term outcomes has not been established. We investigated the effects of acute postoperative cardiopulmonary complications not only on cancer recurrence, but also on cardiovascular or respiratory events in the chronic phase after lung cancer surgery.

Methods

From a prospective single-institution database of 496 consecutive patients, who underwent lung cancer surgery between August, 2008 and December, 2011, medical records, including information about cardiovascular or respiratory events and cancer recurrence in the chronic phase (>6 months) after surgery, were analyzed retrospectively. Results were compared between patients with vs. those without postoperative cardiopulmonary complications in the acute phase.

Results

Postoperative cardiopulmonary complications were identified in 90 (20 %) patients. There were significantly more cardiovascular or respiratory events in the chronic phase after lung cancer surgery in the patients who had suffered postoperative cardiopulmonary complications in the acute phase than in those who had not (23 vs. 5 %; p < 0.0001).

Conclusions

Postoperative cardiopulmonary complications in the acute phase were associated with a higher incidence of cardiovascular or respiratory events in the chronic phase after lung cancer surgery.

Clinical trial registration number

JPRN-UMIN2370

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Allen MS, Darling GE, Pechet TT, Mitchell JD, Herndon JE 2nd, Landreneau RJ, et al. Morbidity and mortality of major pulmonary resections in patients with early-stage lung cancer: initial results of the randomized, prospective ACOSOG Z0030 trial. Ann Thorac Surg. 2006;81:1013–9.

    Article  PubMed  Google Scholar 

  2. Boffa DJ, Allen MS, Grab JD, Gaissert HA, Harpole DH, Wright CD. Data from the society of thoracic surgeons general thoracic surgery database: the surgical management of primary lung tumors. J Thorac Cardiovasc Surg. 2008;135:247–54.

    Article  PubMed  Google Scholar 

  3. Birim O, Kappetein AP, Waleboer M, Puvimanasinghe JP, Eijkemans MJ, Steyerberg EW, et al. Long-term survival after non-small cell lung cancer surgery: development and validation of a prognostic model with a preoperative and postoperative mode. J Thorac Cardiovasc Surg. 2006;132:491–8.

    Article  PubMed  Google Scholar 

  4. Win T, Jackson A, Sharples L, Groves AM, Wells FC, Ritchie AJ, et al. Relationship between pulmonary function and lung cancer surgical outcome. Eur Respir J. 2005;25:594–9.

    Article  CAS  PubMed  Google Scholar 

  5. Suzuki M, Hamada M, Yamamoto K, Kazatani Y, Hiwada K. Brain natriuretic peptide as a risk marker for incident hypertensive cardiovascular events. Hypertens Res. 2002;25:669–76.

    Article  CAS  PubMed  Google Scholar 

  6. Curkendall SM, DeLuise C, Jones JK, Lanes S, Stang MR, Goehring E Jr, et al. Cardiovascular disease in patients with chronic obstructive pulmonary disease, Saskatchewan Canada cardiovascular disease in COPD patients. Ann Epidemiol. 2006;16:63–70.

    Article  PubMed  Google Scholar 

  7. Inoue Y, Kawayama T, Iwanaga T, Aizawa H. High plasma brain natriuretic peptide levels in stable COPD without pulmonary hypertension or cor pulmonale. Intern Med. 2009;48:503–12.

    Article  PubMed  Google Scholar 

  8. Nojiri T, Maeda H, Takeuchi Y, Funakoshi Y, Kimura T, Maekura R, et al. Predictive value of B-type natriuretic peptide for postoperative atrial fibrillation following pulmonary resection for lung cancer. Eur J Cardiothorac Surg. 2010;37:787–91.

    Article  PubMed  Google Scholar 

  9. Nojiri T, Inoue M, Yamamoto K, Maeda H, Takeuchi Y, Funakoshi Y, et al. B-type natriuretic Peptide as a predictor of postoperative cardiopulmonary complications in elderly patients undergoing pulmonary resection for lung cancer. Ann Thorac Surg. 2011;92:1051–5.

    Article  PubMed  Google Scholar 

  10. Nishikimi T, Yoshihara F, Morimoto A, Ishikawa K, Ishimitsu T, Saito Y, et al. Relationship between left ventricular geometry and natriuretic peptide levels in essential hypertension. Hypertension. 1996;28:22–30.

    Article  CAS  PubMed  Google Scholar 

  11. Ledwidge M, Gallagher J, Conlon C, Tallon E, O’Connell E, Dawkins I, et al. Natriuretic peptide-based screening and collaborative care for heart failure: the STOP-HF randomized trial. JAMA. 2013;310:66–74.

    Article  CAS  PubMed  Google Scholar 

  12. Nagaya N, Nishikimi T, Okano Y, Uematsu M, Satoh T, Kyotani S, et al. Plasma brain natriuretic peptide levels increase in proportion to the extent of right ventricular dysfunction in pulmonary hypertension. J Am Coll Cardiol. 1998;31:202–8.

    Article  CAS  PubMed  Google Scholar 

  13. Reesink HJ, Tulevski II, Marcus JT, Boomsma F, Kloek JJ, Vonk Noordegraaf A, et al. Brain natriuretic peptide as noninvasive marker of the severity of right ventricular dysfunction in chronic thromboembolic pulmonary hypertension. Ann Thorac Surg. 2007;84:537–43.

    Article  PubMed  Google Scholar 

  14. Stolz D, Breidthardt T, Christ-Crain M, Bingisser R, Miedinger D, Leuppi J, et al. Use of B-type natriuretic peptide in the risk stratification of acute exacerbations of COPD. Chest. 2008;133:1088–94.

    Article  CAS  PubMed  Google Scholar 

  15. Louie EK, Lin SS, Reynertson SI, Brundage BH, Levitsky S, Rich S. Pressure and volume loading of the right ventricle have opposite effects on left ventricular ejection fraction. Circulation. 1995;92:819–24.

    Article  CAS  PubMed  Google Scholar 

  16. Tsang TS, Gersh BJ, Appleton CP, Tajik AJ, Barnes ME, Bailey KR, et al. Left ventricular diastolic dysfunction as a predictor of the first diagnosed nonvalvular atrial fibrillation in 840 elderly men and women. J Am Coll Cardiol. 2002;40:1636–44.

    Article  PubMed  Google Scholar 

  17. Barr RG, Bluemke DA, Ahmed FS, Carr JJ, Enright PL, Hoffman EA, et al. Percent emphysema, airflow obstruction, and impaired left ventricular filling. N Engl J Med. 2010;362:217–27.

    Article  PubMed Central  PubMed  Google Scholar 

  18. Lubien E, DeMaria A, Krishnaswamy P, Clopton P, Koon J, Kazanegra R, et al. Utility of B-natriuretic peptide in detecting diastolic dysfunction: comparison with Doppler velocity recordings. Circulation. 2002;105:595–601.

    Article  CAS  PubMed  Google Scholar 

  19. Goto T, Ohte N, Wakami K, Asada K, Fukuta H, Mukai S, et al. Usefulness of plasma brain natriuretic peptide measurement and tissue Doppler imaging in identifying isolated left ventricular diastolic dysfunction without heart failure. Am J Cardiol. 2010;106:87–91.

    Article  CAS  PubMed  Google Scholar 

  20. Nojiri T, Maeda H, Takeuchi Y, Funakoshi Y, Maekura R, Yamamoto K, et al. Predictive value of preoperative tissue Doppler echocardiographic analysis for postoperative atrial fibrillation after pulmonary resection for lung cancer. J Thorac Cardiovasc Surg. 2010;140:764–8.

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

No financial support for the study was provided by any organization. We declare no financial disclosures or conflicts of interest.

Author information

Authors and Affiliations

  1. Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Yamadaoka 2-2 (L5), Suita, Osaka, 565-0871, Japan

    Takashi Nojiri, Masayoshi Inoue, Yasushi Shintani, Noriyoshi Sawabata & Meinoshin Okumura

  2. Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan

    Takashi Nojiri

  3. Department of General Thoracic Surgery, National Hospital Organization Toneyama Hospital, Toyonaka, Osaka, Japan

    Yukiyasu Takeuchi & Hajime Maeda

  4. Department of Biomedical Statistics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

    Toshimitsu Hamasaki

Authors
  1. Takashi Nojiri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Masayoshi Inoue
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yukiyasu Takeuchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hajime Maeda
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yasushi Shintani
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Noriyoshi Sawabata
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Toshimitsu Hamasaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Meinoshin Okumura
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Takashi Nojiri.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Nojiri, T., Inoue, M., Takeuchi, Y. et al. Impact of cardiopulmonary complications of lung cancer surgery on long-term outcomes. Surg Today 45, 740–745 (2015). https://doi.org/10.1007/s00595-014-1032-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00595-014-1032-z

Keywords

Search

Navigation