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Randomized controlled trial of the LigaSure vessel sealing system versus conventional open gastrectomy for gastric cancer

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Abstract

Purpose

LigaSure, a bipolar electronic vessel sealing system, has become popular in abdominal surgery but few clinical studies have been conducted to evaluate its effectiveness in radical gastrectomy for gastric cancer.

Methods

In this multicenter, prospective, randomized controlled trial, patients with curative gastric cancer were randomly assigned to undergo gastrectomy either with LigaSure or a conventional technique.

Results

Of the 160 patients enrolled, 80 were randomized to the LigaSure group and 78 to the conventional group. Patient characteristics were well balanced in the two groups. There were no significant differences between the LigaSure and conventional groups in blood loss (288 vs. 260 ml, respectively; P = 0.748) or operative time (223 and 225 min, respectively; P = 0.368); nor in the incidence of surgical complications or duration of postoperative hospital stay. In a subgroup analysis of patients who underwent gastrectomy that preserved the distal part of the greater omentum, the use of LigaSure significantly reduced blood loss (179 vs. 245 ml; P = 0.033), and the duration of the operation (195 vs. 221 min; P = 0.039).

Conclusions

LigaSure did not contribute to reducing intraoperative blood loss, operative time, or other adverse surgical outcomes. The usefulness of the device may be limited to a specific part of the surgical procedure in open gastrectomy.

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Acknowledgments

This work was supported in part by SCCRE (Supporting Center for Clinical Research Education, Osaka, Japan).

Conflict of interest

None declared.

Author information

Authors and Affiliations

  1. Department of Surgery, NTT West Osaka Hospital Osaka, Osaka, Japan

    Junya Fujita

  2. Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan

    Shuji Takiguchi, Yukinori Kurokawa, Masaki Mori & Yuichiro Doki

  3. Department of Surgery, National Hospital Organization, Osaka National Hospital, Osaka, Japan

    Kazuhiro Nishikawa

  4. Department of Surgery, Sakai Municipal Hospital, Sakai, Japan

    Yutaka Kimura

  5. Department of Surgery, Toyonaka Municipal Hospital, Toyonaka, Japan

    Hiroshi Imamura

  6. Department of Surgery, Kansai Rosai Hospital, Amagasaki, Japan

    Shigeyuki Tamura

  7. Department of Surgery, Suita Municipal Hospital, Suita, Japan

    Chikara Ebisui

  8. Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan

    Kentaro Kishi

  9. Department of Surgery, Osaka General Medical Center, Osaka, Japan

    Kazumasa Fujitani

Authors
  1. Junya Fujita
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  2. Shuji Takiguchi
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  3. Kazuhiro Nishikawa
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  4. Yutaka Kimura
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  5. Hiroshi Imamura
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  6. Shigeyuki Tamura
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  7. Chikara Ebisui
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  8. Kentaro Kishi
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  9. Kazumasa Fujitani
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  10. Yukinori Kurokawa
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  11. Masaki Mori
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  12. Yuichiro Doki
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Corresponding author

Correspondence to Shuji Takiguchi.

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Fujita, J., Takiguchi, S., Nishikawa, K. et al. Randomized controlled trial of the LigaSure vessel sealing system versus conventional open gastrectomy for gastric cancer. Surg Today 44, 1723–1729 (2014). https://doi.org/10.1007/s00595-014-0930-4

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  • DOI: https://doi.org/10.1007/s00595-014-0930-4

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