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Usefulness of the neutrophil/lymphocyte ratio measured preoperatively as a predictor of peritoneal metastasis in patients with advanced gastric cancer

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Abstract

Purpose

The prognosis for gastric cancer patients with peritoneal metastasis is poor. Many studies have reported that the neutrophil/lymphocyte ratio (NLR) might be useful to predict the degree of progression of gastric cancer. In this study, we attempted to evaluate whether the NLR and other related laboratory parameters might be reliable predictors of the presence of peritoneal metastasis in patients with advanced gastric cancer.

Methods

The data of 359 patients who underwent gastric surgery between June 2008 and December 2011 were reviewed. A retrospective analysis of the preoperative blood data in relation to the presence of peritoneal metastasis was carried out.

Results

An increased serum C-reactive protein level (P = 0.022), APTT (P = 0.017) and NLR (P < 0.001), and a decreased serum Alb (P = 0.014) were significantly related to the presence of peritoneal metastasis. A multivariate analysis showed that a NLR >2.37 (OR = 2.59, 95 % CI = 1.38–4.93, P = 0.003) and clinical T4 stage (OR = 4.36, 95 % CI = 2.33–8.24, P < 0.001) were independent predictors of the presence of peritoneal metastasis.

Conclusion

Our results suggest that the preoperative NLR was a significant independent predictor of the presence of peritoneal metastasis in patients with advanced gastric cancer.

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Conflict of interest

Y. Nakayama and co-authors have no conflict of interest to report.

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Authors and Affiliations

  1. Division of Surgical Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, 277-8577, Japan

    Yusuke Nakayama, Naoto Gotohda, Hidehito Shibasaki & Takahiro Kinoshita

  2. Juntendo University Graduate School of Medicine, Tokyo, Japan

    Yusuke Nakayama & Ryuichi Hayashi

  3. Department of Biostatistics, National Cancer Center, Kashiwa, Japan

    Shogo Nomura

  4. Division of Head and Neck Surgery, National Cancer Center Hospital East, Kashiwa, Japan

    Ryuichi Hayashi

Authors
  1. Yusuke Nakayama
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  2. Naoto Gotohda
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  3. Hidehito Shibasaki
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  5. Takahiro Kinoshita
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  6. Ryuichi Hayashi
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Correspondence to Naoto Gotohda.

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Nakayama, Y., Gotohda, N., Shibasaki, H. et al. Usefulness of the neutrophil/lymphocyte ratio measured preoperatively as a predictor of peritoneal metastasis in patients with advanced gastric cancer. Surg Today 44, 2146–2152 (2014). https://doi.org/10.1007/s00595-014-0917-1

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  • DOI: https://doi.org/10.1007/s00595-014-0917-1

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