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Postoperative outcomes of patients with hepatocellular carcinoma negative for all virus-related markers

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Abstract

Purpose

The outcomes of patients with resectable hepatocellular carcinoma (HCC) negative for all virus-related markers have not yet been characterized. This study investigated the outcomes of such patients in comparison to those who had virus-related resectable HCC.

Methods

A total of 398 patients with HCC were divided into 2 groups, comprising patients in which all virus-related markers (HBs-Ag, HBs-Ab, HBe-Ag, HBe-Ab, HBc-Ab, HCV-Ab) were negative (all-negative group, n = 63) and those with at least 1 positive virus-related marker (virus-related group, n = 335). The clinical characteristics, surgical data, and survival rates were compared between the groups.

Results

The serum AST (30 vs. 45 IU/l, P < 0.0001) and ALT (21 vs. 42 IU/l, P < 0.0001) levels were significantly lower in the all-negative group than in the virus-related group. The tumor size (4.3 vs. 3.1 cm, P < 0.0001), the prevalence of DM (46.8 vs. 25.4 %, P = 0.001), and BMI (24.8 vs. 22.9, P = 0.0023) were significantly higher in the all-negative group than in the virus-related group. HCC arose from a cirrhotic liver in a significantly higher proportion of patients in the virus-related group than in the all-negative group (20.6 vs. 44.8 %, P = 0.0002). The survival outcomes were not significantly different in the 2 groups (all-negative vs. virus-related: 5-year overall survival rate, 58.2 vs. 55.2 %, P = 0.27), despite such differences in the patients’ characteristics.

Conclusions

The postoperative outcomes of patients with HCC are independent of the presence or absence of hepatitis viral infection.

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Acknowledgments

This work was mainly supported by a Grant-in-Aid for Scientific Research (A) 24249068 (T.T.) and (C) 21500662 (H.N.) and 23591972 (Y.M.) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan.

Conflict of interest

Ichiro Yamato and the other co-authors have no conflict of interest to declare.

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Authors and Affiliations

  1. Department of Digestive Surgery, Nihon University School of Medicine, 30-1 Ohyaguchikami-machi, Itabashi-ku, Tokyo, 173-8610, Japan

    Ichiro Yamato, Tadatoshi Takayama, Yutaka Midorikawa, Tokio Higaki, Hisashi Nakayama & Masamichi Moriguchi

  2. Department of Surgery, Nara Medical University, Nara, Japan

    Ichiro Yamato & Yoshiyuki Nakajima

  3. Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan

    Shunichi Matsuoka, Masahiro Ogawa & Mitsuhiko Moriyama

Authors
  1. Ichiro Yamato
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  2. Tadatoshi Takayama
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  3. Yutaka Midorikawa
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  4. Tokio Higaki
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  5. Hisashi Nakayama
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  7. Yoshiyuki Nakajima
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  8. Shunichi Matsuoka
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  9. Masahiro Ogawa
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  10. Mitsuhiko Moriyama
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Correspondence to Tadatoshi Takayama.

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Yamato, I., Takayama, T., Midorikawa, Y. et al. Postoperative outcomes of patients with hepatocellular carcinoma negative for all virus-related markers. Surg Today 43, 865–870 (2013). https://doi.org/10.1007/s00595-012-0308-4

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  • DOI: https://doi.org/10.1007/s00595-012-0308-4

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