Abstract
A 49-year-old woman was admitted to our hospital under suspicion of an enlarging hepatic tumor, which had been previously diagnosed to be a cavernous hemangioma. Computed tomography revealed three enhanced tumors, one measuring 15 cm in diameter within the right lobe of the liver and two intrahepatic metastases in Couinaud’s hepatic segments 3 and 5. We diagnosed the patient to have primary liver cancer, and suspected a combined liver tumor preoperatively. We performed a right trisectionectomy with radiofrequency ablation of the intrahepatic metastasis in S3. According to the immunohistochemical findings of the resected specimen and the findings of postoperative imaging studies, the tumor was diagnosed to be a primary neuroendocrine tumor in the liver. The patient is presently alive without recurrence at 33 months after the operation.
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Knox CD, Anderson CD, Lamps LW, Adkins RB, Pinson CW. Long-term survival after resection for primary hepatic carcinoid tumor. Ann Surg Oncol 2003;10:1171–1175.
Liver Cancer Study Group of Japan. General rules for the clinical and pathological study of primary liver cancer. 5th ed., revised. Tokyo: Kanehara; 2009.
Solcia E, Klöppel G, Sobin LH, Williams ED, World Health Organization. Histological typing of endocrine tumours. 2nd ed. Berlin Heidelberg New York: Springer; 2000.
Arnold R. Endocrine tumours of the gastrointestinal tract. Introduction: definition, historical aspects, classification, staging, prognosis and therapeutic options. Best Pract Res Clin Gastroenterol 2005;19:491–505.
Edmondson HA. Tumors of the liver and intrahepatic bile ducts. Washington: Armed Forces Institute of Pathology; 1958.
Huang YQ, Xu F, Yang JM, Huang B. Primary hepatic neuroendocrine carcinoma: clinical analysis of 11 cases. Hepatobiliary Pancreat Dis Int 2010;9:44–48.
Hsueh C, Tan XD, Gonzalez-Crussi F. Primary hepatic neuroendocrine carcinoma in a child. Morphologic, immunocytochemical, and molecular biologic studies. Cancer 1993;71:2660–2665.
Zanconati F, Falconieri G, Lamovec J, Zidar A. Small cell carcinoma of the liver: a hitherto unreported variant of hepatocellular carcinoma. Histopathology 1996;29:449–453.
Pilichowska M, Kimura N, Ouchi A, Lin H, Mizuno Y, Nagura H. Primary hepatic carcinoid and neuroendocrine carcinoma: clinicopathological and immunohistochemical study of five cases. Pathol Int 1999;49:318–324.
Ishida M, Seki K, Tatsuzawa A, Katayama K, Hirose K, Azuma T, et al. Primary hepatic neuroendocrine carcinoma coexisting with hepatocellular carcinoma in hepatitis C liver cirrhosis: report of a case. Surg Today 2003;33:214–218.
Garcia MT, Bejarano PA, Yssa M, Buitrago E, Livingstone A. Tumor of the liver (hepatocellular and high grade neuroendocrine carcinoma): a case report and review of the literature. Virchows Arch 2006;449:376–381.
Lin CW, Lai CH, Hsu CC, Hsu CT, Hsieh PM, Hung KC, et al. Primary hepatic carcinoid tumor: a case report and review of the literature. Cases J 2009;2:90.
Akahoshi T, Higashi H, Tsuruta S, Tahara K, Matsumoto T, Takeuchi H, et al. Primary neuroendocrine carcinoma coexisting with hemangioma in the liver: report of a case. Surg Today 2010; 40:185–189.
Oberg K, Kvols L, Caplin M, Delle Fave G, De Herder W, Rindi G, et al. Consensus report on the use of somatostatin analogs for the management of neuroendocrine tumors of the gastroenteropancreatic system. Ann Oncol 2004;15:966–973.
Rinke A, Muller HH, Schade-Brittinger C, Klose KJ, Barth P, Wied M, et al. Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group. J Clin Oncol 2009;27:4656–4663.
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Mima, K., Beppu, T., Murata, A. et al. Primary neuroendocrine tumor in the liver treated by hepatectomy: Report of a case. Surg Today 41, 1655–1660 (2011). https://doi.org/10.1007/s00595-011-4497-z
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DOI: https://doi.org/10.1007/s00595-011-4497-z