Skip to main content
SpringerLink
Log in

Tissue engineered myoblast sheets improved cardiac function sufficiently to discontinue LVAS in a patient with DCM: report of a case

  • Case Report
  • Published:
Surgery Today Aims and scope Submit manuscript

Abstract

Dilated cardiomyopathy (DCM) is a heart muscle disease characterized by progressive heart failure, and is a leading cause of mortality and morbidity. Recently, cellular therapy for end-stage heart failure has been emerging. We herein report a 56-year-old male who received a transplant of autologous myoblast sheets manufactured in temperature-responsive culture dishes. His clinical condition improved markedly, leaving him without any arrhythmia and able to discontinue using a left ventricular assist system and avoid cardiac transplantation. These findings suggest that cellular therapy using myoblast sheets is a promising new strategy for treating patients with end-stage DCM. This method might be an effective alternative to heart transplantation in the near future.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Dandel M, Weng Y, Siniawski H, Potapov E, Lehmkuhl HB, Hetzer R. Long-term results in patients with idiopathic dilated cardiomyopathy after weaning from left ventricular assist devices. Circulation. 2005;112:I37–45.

    Article  PubMed  Google Scholar 

  2. Hata H, Matsumiya G, Miyagawa S, et al. Grafted skeletal myoblast sheets attenuate myocardial remodeling in pacing-induced canine heart failure model. J Thorac Cardiovasc Surg. 2006;132:918–24.

    Article  PubMed  Google Scholar 

  3. Menasche P, Alfieri O, Janssens S, et al. The myoblast autologous grafting in ischemic cardiomyopathy (MAGIC) trial: first randomized placebo-controlled study of myoblast transplantation. Circulation. 2008;117:1189–200.

    Article  PubMed  Google Scholar 

  4. Memon IA, Sawa Y, Fukushima N, et al. Repair of impaired myocardium by means of implantation of engineered autologous myoblast sheets. J Thorac Cardiovasc Surg. 2005;130:1333–41.

    Article  PubMed  Google Scholar 

  5. Miyagawa S, Sawa Y, Sakakida S, et al. Tissue cardiomyoplasty using bioengineered contractile cardiomyocyte sheets to repair damaged myocardium: their integration with recipient myocardium. Transplantation. 2005;80:1586–95.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan

    Yoshiki Sawa, Shigeru Miyagawa, Taichi Sakaguchi & Tomoyuki Fujita

  2. Medical Center of Translational Research, Osaka University Graduate School of Medicine, Suita, Japan

    Akifumi Matsuyama & Atsuhiro Saito

  3. Tokyo Women’s Medical University Institute of Advanced Biomedical Engineering and Science, Tokyo, Japan

    Tatsuya Shimizu & Teruo Okano

Authors
  1. Yoshiki Sawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shigeru Miyagawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Taichi Sakaguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tomoyuki Fujita
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Akifumi Matsuyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Atsuhiro Saito
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Tatsuya Shimizu
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Teruo Okano
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yoshiki Sawa.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sawa, Y., Miyagawa, S., Sakaguchi, T. et al. Tissue engineered myoblast sheets improved cardiac function sufficiently to discontinue LVAS in a patient with DCM: report of a case. Surg Today 42, 181–184 (2012). https://doi.org/10.1007/s00595-011-0106-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00595-011-0106-4

Keywords

Search

Navigation