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Interleukin 6 and interleukin 8 play important roles in systemic inflammatory response syndrome of meconium peritonitis

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Abstract

Purpose

Meconium peritonitis is caused by an intestinal perforation that may occur in the fetus, followed by severe chemical peritonitis, resulting in high morbidity.

Methods

We have experienced six patients with meconium peritonitis. Cystic drainage was performed soon after birth for all patients. We investigated the concentrations of several cytokines and a chemokine (interleukin 8) in the ascites from the six patients with meconium peritonitis. In two patients we also measured the serum cytokines and chemokine level just after birth.

Results

Interleukin 6 and interleukin 8 concentrations were very high in the cyst or ascites just after birth. In the serum taken from two patients, the levels of interleukin 6 and interleukin 8 were also high. In five patients who underwent drainage of cysts after birth, systemic inflammation could not be completely suppressed before curative surgery.

Conclusions

Interleukin 6 and interleukin 8 play important roles in the inflammatory response syndrome associated with meconium peritonitis, and drainage of cystic fluid did not completely suppress this inflammation. To lessen the high morbidity of meconium peritonitis, efforts should be made to suppress the inflammatory response using new treatment strategies, such as administration of steroids or anti-cytokine therapy to supplement cystic drainage.

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Authors and Affiliations

  1. Department of Pediatric Surgery, University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Yutaka Kanamori, Kan Terawaki, Masahiko Sugiyama, Makoto Komura, Tetsuro Kodaka, Kan Suzuki & Tadashi Iwanaka

  2. Department of General Surgery, National Center for Child Health and Development, 2-10-1 Ohkura, Setagaya-ku, Tokyo, 157-8535, Japan

    Yutaka Kanamori, Hajime Takayasu, Yoshihiro Kitano & Tatsuo Kuroda

Authors
  1. Yutaka Kanamori
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  2. Kan Terawaki
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  3. Hajime Takayasu
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  4. Masahiko Sugiyama
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  5. Makoto Komura
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  6. Tetsuro Kodaka
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  7. Kan Suzuki
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  8. Yoshihiro Kitano
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  9. Tatsuo Kuroda
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  10. Tadashi Iwanaka
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Corresponding author

Correspondence to Yutaka Kanamori.

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Kanamori, Y., Terawaki, K., Takayasu, H. et al. Interleukin 6 and interleukin 8 play important roles in systemic inflammatory response syndrome of meconium peritonitis. Surg Today 42, 431–434 (2012). https://doi.org/10.1007/s00595-011-0034-3

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  • DOI: https://doi.org/10.1007/s00595-011-0034-3

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