Abstract
We report a case of a gastrointestinal stromal tumor (GIST) with strong and faint KIT protein staining, respectively, at two different sites. A single point mutation (c1727 T>C) was detected in DNA extracted from both sites, and a further deletion mutation (c1678_1680 del GTT) was detected in DNA from the site with strong KIT protein staining. Cloning analysis indicated that the point mutation and the deletion were present on different alleles.
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Ichikawa, Y., Miyagi, Y., Fujii, S. et al. Gastrointestinal stromal tumor with two genetic abnormalities on different alleles: Report of a case. Surg Today 40, 262–266 (2010). https://doi.org/10.1007/s00595-008-4029-7
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DOI: https://doi.org/10.1007/s00595-008-4029-7