Skip to main content
SpringerLink
Log in

Mesenchymal Hamartoma of the Liver Accompanied by a Daughter Nodule: Report of a Case

  • Case Report
  • Published:
Surgery Today Aims and scope Submit manuscript

Abstract

Mesenchymal hamartoma of the liver (MHL) is an uncommon benign tumor found primarily in children younger than 2 years of age. We report a rare case of MHL with a daughter nodule and atypical histological findings in a 14-month-old girl. On admission, computed tomography, magnetic resonance imaging, and angiography showed a solid hypovascular mass with a central cystic area in the liver. Laparotomy revealed a tumor, 8 cm in size, occupying segment 5 and parts of segments 4 and 6 of the liver, and a small nodule, 10 mm in size, in segment 7. Thus, we performed a partial hepatic resection (S4–6) and tumor extirpation (S7). The histological findings of both tumors were the same, but atypical of MHL. Recent studies on the pathogenesis of this tumor have found neoplastic features such as genetic anomalies and malignant transformation. These findings suggest that the conventional approach of completely resecting the tumor whenever possible is the best treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. HA Edmondson (1956) ArticleTitleDifferential diagnosis of tumors and tumor-like lesions of liver in infancy and childhood AMA J Dis Child 91 168–86 Occurrence Handle13282629 Occurrence Handle1:STN:280:CymD3svotFc%3D

    PubMed  CAS  Google Scholar 

  2. S Kamata K Nose T Sawai T Hasegawa S Kuroda T Sasaki et al. (2003) ArticleTitleFetal mesenchymal hamartoma of the liver: report of a case J Pediatr Surg 38 639–41 Occurrence Handle12677586 Occurrence Handle10.1053/jpsu.2003.50142

    Article  PubMed  Google Scholar 

  3. JT Stocker KG Ishak (1983) ArticleTitleMesenchymal hamartoma of the liver: report of 30 cases and review of the literature Pediatr Pathol 1 245–67 Occurrence Handle6687279 Occurrence Handle1:STN:280:BiqD3sfivFE%3D

    PubMed  CAS  Google Scholar 

  4. A Helal M Nolan R Bower B Mair D Debich-Spicer (1995) ArticleTitlePathological case of the month. Mesenchymal hamartoma of the liver Arch Pediatr Adolesc Med 149 315–6 Occurrence Handle7858693 Occurrence Handle1:STN:280:ByqC283isF0%3D

    PubMed  CAS  Google Scholar 

  5. JB Yen MS Kong JN Lin (2003) ArticleTitleHepatic mesenchymal hamartoma J Paediatr Child Health 39 632–4 Occurrence Handle14629534 Occurrence Handle10.1046/j.1440-1754.2003.00250.x

    Article  PubMed  Google Scholar 

  6. F Boman C Bossard M Fabre N Diab M Bonnevalle L Boccon-Gibod (2004) ArticleTitleMesenchymal hamartomas of the liver may be associated with increased serum alpha foetoprotein concentrations and mimic hepatoblastomas Eur J Pediatr Surg 14 63–6 Occurrence Handle15024683 Occurrence Handle10.1055/s-2004-815784 Occurrence Handle1:STN:280:DC%2BD2c7jtFCrtQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  7. H Ito T Kishikawa T Toda M Arai H Muro (1984) ArticleTitleHepatic mensenchymal hamartoma of an infant J Pediatr Surg 19 315–7 Occurrence Handle6205130 Occurrence Handle10.1016/S0022-3468(84)80197-9 Occurrence Handle1:STN:280:BiuB28jitVw%3D

    Article  PubMed  CAS  Google Scholar 

  8. KJ Mortele PR Ros (2002) ArticleTitleBenign liver neoplasms Clin Liver Dis 6 119–45 Occurrence Handle11933585 Occurrence Handle10.1016/S1089-3261(03)00069-2

    Article  PubMed  Google Scholar 

  9. K Kanto K Kato T Hebiguchi H Yoshino K Koyama (1990) ArticleTitleFetal mesenchymal hamartoma of the liver: Report of a case. Journal of the Japan Society of Pediatric Surgery 26 706–12

    Google Scholar 

  10. LP Dehner SL Ewing HW Sumner (1975) ArticleTitleInfantile mesenchymal hamartoma of the liver. Histologic and ultrastructural observations Arch Pathol 99 379–82 Occurrence Handle1170838 Occurrence Handle1:STN:280:CSqB3cvmtV0%3D

    PubMed  CAS  Google Scholar 

  11. DC Barnhart RB Hirschl KA Garver JD Geiger CM Harmon AG Coran (1997) ArticleTitleConservative management of mesenchymal hamartoma of the liver J Pediatr Surg 32 1495–8 Occurrence Handle9349781 Occurrence Handle10.1016/S0022-3468(97)90574-1 Occurrence Handle1:STN:280:DyaK1c%2Fgsl2gtQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  12. AC al-Rikabi A Buckai S Al-Sumayer S Al-Damegh AR Al-Bassam (2000) ArticleTitleFine needle aspiration cytology of mesenchymal hamartoma of the liver. A case report Acta Cytol 44 449–53 Occurrence Handle10834010 Occurrence Handle1:STN:280:DC%2BD3c3ptl2hsg%3D%3D

    PubMed  CAS  Google Scholar 

  13. D von Schweinitz BG Dammeier S Gluer (1999) ArticleTitleMesenchymal hamartoma of the liver—new insight into histogenesis J Pediatr Surg 34 1269–71 Occurrence Handle10466610 Occurrence Handle10.1016/S0022-3468(99)90166-5 Occurrence Handle1:STN:280:DyaK1MzpsVCrtA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  14. I Abdulkader M Fraga E Perez-Becerra RM Reyes-Santias A Bautista E Chaves et al. (2004) ArticleTitleMesenchymal hamartoma of the liver; clinicopathological, immunohistochemical and flow cytometric study of two cases Hepatol Res 28 216–9 Occurrence Handle15040962 Occurrence Handle10.1016/j.hepres.2003.11.007

    Article  PubMed  Google Scholar 

  15. TM Ramanujam JC Ramesh DW Goh KT Wong WA Ariffin G Kumar et al. (1999) ArticleTitleMalignant transformation of mesenchymal hamartoma of the liver: case report and review of the literature J Pediatr Surg 34 1684–6 Occurrence Handle10591570 Occurrence Handle10.1016/S0022-3468(99)90644-9 Occurrence Handle1:STN:280:DC%2BD3c%2FlslGksg%3D%3D

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatric Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan

    Suguru Fukahori, Tomomitsu Tsuru, Ken Tanikawa, Kenjiro Akiyoshi, Kimio Asagiri, Yoshiaki Tanaka & Minoru Yagi

  2. Department of Pathology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan

    Masayoshi Kage & Masamichi Kojiro

  3. Chikugo Municipal Hospital, Chikugo, Fukuoka, Japan

    Hiroyoshi Mizote

Authors
  1. Suguru Fukahori
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tomomitsu Tsuru
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ken Tanikawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kenjiro Akiyoshi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Kimio Asagiri
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yoshiaki Tanaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Masayoshi Kage
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Masamichi Kojiro
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Hiroyoshi Mizote
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Minoru Yagi
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fukahori, S., Tsuru, T., Tanikawa, K. et al. Mesenchymal Hamartoma of the Liver Accompanied by a Daughter Nodule: Report of a Case. Surg Today 37, 811–816 (2007). https://doi.org/10.1007/s00595-007-3494-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00595-007-3494-8

Key words

Search

Navigation