Abstract
Purpose
Combined hepatocellular and cholangiocarcinoma (HCC-CC) is a rare primary hepatic neoplasm (PHN) with features of both hepatocellular and biliary differentiation. We compared the outcome of hepatic resection in patients with HCC-CC, those with hepatocelluar carcinoma (HCC), and those with cholangiocarcinoma (ICC).
Methods
Between November 1994 and December 2003, 952 patients underwent hepatic resection for a PHN.
Results
The incidence of HCC-CC was 3.5%. Hepatitis B surface antigen was positive in 51.2% of these patients and the HCV antibody was positive in 12.2%. Positive hepatitis serology was more common in the HCC group (66.7%). The prevalence of underlying liver cirrhosis was significantly lower in the ICC group (7.8%) than in the HCC (49%) and HCC-CC (41.5%) groups (P < 0.0001). The median overall survival periods after hepatic resection of HCC-CC, HCC, and ICC were 47.3, 71.7, and 21.5 months, respectively (P < 0.0001). The median disease-free survival (DFS) periods after hepatic resection for HCC-CC, HCC, and ICC were 23.4, 68.2, and 15.5 months, respectively (P < 0.0001).
Conclusion
Patients with transitional type HCC-CC had significantly poorer survival rates than those with HCC, after hepatic resection. Therefore, a more aggressive treatment modality should be explored to improve the survival rate of these patients.
Similar content being viewed by others
References
ZD Goodman KG Ishak JM Langloss IA Sesterhenn L Rabin (1985) ArticleTitleCombined hepatocellular-cholangiocarcinoma. A histologic and immunohistochemical study Cancer 55 124–35 Occurrence Handle2578078 Occurrence Handle1:STN:280:DyaL2M%2Fntl2mtA%3D%3D Occurrence Handle10.1002/1097-0142(19850101)55:1<124::AID-CNCR2820550120>3.0.CO;2-Z
R Allen J Lisa (1949) ArticleTitleCombined liver cell and bile duct carcinoma Am J Pathol 25 647–55 Occurrence Handle18152860 Occurrence Handle1:STN:280:DyaH1M%2FlsVCgtQ%3D%3D
K Ishak P Anthony L Sobin (Eds) (1994) Histological typing of the liver. International histological classification of tumors WHO EditionNumber2nd ed Springer Hong Kong
T Maeda E Adachi K Kajiyama K Sugimachi M Tsuneyoshi (1995) ArticleTitleCombined hepatocellular and cholangiocarcinoma: proposed criteria according to cytokeratin expression and analysis of clinicopathologic features Hum Pathol 26 956–64 Occurrence Handle7545644 Occurrence Handle1:STN:280:DyaK2Mvgt12msQ%3D%3D Occurrence Handle10.1016/0046-8177(95)90084-5
Edmonson H. Tumors of the liver and intrahepatic bile ducts. Atlas of tumor pathology 1958:32–105
InstitutionalAuthorNameLiver Cancer Study Group of Japan (1997) Classification of primary liver cancer EditionNumber1st ed Kanehara Tokyo
LH Sobin C Wittekind (1997) TNM classification of malignant tumors EditionNumber5th ed Wiley-Liss New York 74–7
H Wells (1903) ArticleTitlePrimary carcinoma of the liver Am J Sci 126 403–17 Occurrence Handle10.1097/00000441-190309000-00004
WR Jarnagin S Weber SK Tickoo JB Koea S Obiekwe Y Fong et al. (2002) ArticleTitleCombined hepatocellular and cholangiocarcinoma: demographic, clinical, and prognostic factors Cancer 94 2040–6 Occurrence Handle11932907 Occurrence Handle10.1002/cncr.10392
IO Ng TW Shek J Nicholls LT Ma (1998) ArticleTitleCombined hepatocellular-cholangiocarcinoma: a clinicopathological study J Gastroenterol Hepatol 13 34–40 Occurrence Handle9737569 Occurrence Handle1:STN:280:DyaK1cvgslGrtQ%3D%3D
M Tomimatsu N Ishiguro M Taniai H Okuda A Saito H Obata et al. (1993) ArticleTitleHepatitis C virus antibody in patients with primary liver cancer (hepatocellular carcinoma, cholangiocarcinoma, and combined hepatocellular-cholangiocarcinoma) in Japan Cancer 72 683–8 Occurrence Handle8192727 Occurrence Handle1:STN:280:DyaK3szisleitQ%3D%3D Occurrence Handle10.1002/1097-0142(19930801)72:3<683::AID-CNCR2820720310>3.0.CO;2-C
CL Liu ST Fan CM Lo IO Ng CM Lam RT Poon et al. (2003) ArticleTitleHepatic resection for combined hepatocellular and cholangiocarcinoma Arch Surg 138 86–90 Occurrence Handle12511158 Occurrence Handle10.1001/archsurg.138.1.86
J Taguchi O Nakashima M Tanaka T Hisaka T Takazawa M Kojiro (1996) ArticleTitleA clinicopathological study on combined hepatocellular and cholangiocarcinoma J Gastroenterol Hepatol 11 758–64 Occurrence Handle8872774 Occurrence Handle1:STN:280:DyaK2s%2Fis1GqtA%3D%3D
Y Yano J Yamamoto T Kosuge Y Sakamoto S Yamasaki K Shimada et al. (2003) ArticleTitleCombined hepatocellular and cholangiocarcinoma: a clinicopathologic study of 26 resected cases Jpn J Clin Oncol 33 283–7 Occurrence Handle12913082 Occurrence Handle10.1093/jjco/hyg056
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lee, WS., Lee, KW., Heo, JS. et al. Comparison of Combined Hepatocellular and Cholangiocarcinoma with Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma. Surg Today 36, 892–897 (2006). https://doi.org/10.1007/s00595-006-3276-8
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s00595-006-3276-8