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Arterio-jugular Differences in Serum S-100β Proteins in Patients Receiving Selective Cerebral Perfusion

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Abstract

Purpose

The early increase in serum S100β after cardiopulmonary bypass (CPB) seems to be derived from an extracerebral source. To exclude contamination, we investigated the arterio-jugular differences in S100β levels in patients receiving selective cerebral perfusion (SCP). We also evaluated the brain-protective effect of SCP by comparing the arterial S100β levels with those in patients undergoing coronary artery bypass grafting (CABG).

Methods

We measured arterial and jugular venous levels of S100β in ten patients undergoing aortic arch repair with SCP for up to 12 h postoperatively (SCP group). We also measured arterial levels of S100β in nine patients undergoing CABG (CPB group).

Results

There was no incidence of hospital death or stroke. The arterial levels of S100β in both groups were comparable and peaked just after the conclusion of CPB. The arterial and jugular venous levels of S100β were almost equivalent. The arterio-jugular differences in S100β levels were negligible, even in our SCP-group patient with postoperative delirium, who had a peak value three times higher than the other patients.

Conclusions

The arterio-jugular differences in S100β did not clarify the origin of their increase. Thus, measuring the jugular venous levels of S100β in patients without postoperative clinical neurological deterioration would be of little benefit. However, SCP seems to protect the brain against S100β release as effectively as conventional CPB.

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Authors and Affiliations

  1. Department of Cardiovascular Surgery, Hokkaido University School of Medicine, N14, W5, Kita-ku, Sapporo, 060-8648, Japan

    Takashi Kunihara, Norihiko Shiiya, Luo Bin & Keishu Yasuda

Authors
  1. Takashi Kunihara
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  2. Norihiko Shiiya
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  3. Luo Bin
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  4. Keishu Yasuda
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Additional information

This paper was presented in part at the 31st Annual Meeting of the Japanese Society for Cardiovascular Surgery (Yamaguchi, Japan, February, 2001).

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Kunihara, T., Shiiya, N., Bin, L. et al. Arterio-jugular Differences in Serum S-100β Proteins in Patients Receiving Selective Cerebral Perfusion. Surg Today 36, 6–11 (2006). https://doi.org/10.1007/s00595-005-3105-5

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  • DOI: https://doi.org/10.1007/s00595-005-3105-5

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