Abstract
Purpose
To determine whether interlobar pleural invasion into the adjacent lobe (interlobar P3) should be assessed as T3 according to the tumor-node metastasis classification.
Methods
Surgically treated patients with primary lung cancer (n = 322) were analyzed.
Results
Tumors with interlobar P3 had a significantly lower incidence of mass screening detection, a higher occurrence rate of squamous cell carcinoma, and a larger tumor diameter than tumors without interlobar P3. The lymph node metastatic rate did not differ between the patients with and without interlobar P3. The 5-year survival rate of patients with interlobar P3 was 63% and the rates of other patients were 56% with T1 disease, 57% with T2, 31% with T3, and 19% with T4. The survival rate for patients with interlobar P3 was higher than for those with T3 without interlobar P3 (P < 0.05). The 5-year survival rate of the patients with interlobar P3 was lower in adenocarcinoma (39%) than in squamous cell carcinoma (69%, P < 0.01). The results were similar when the analysis was restricted to patients without lymph node metastasis. In adenocarcinoma, the survival rate for interlobar P3 was between the rates for T2 (53%) and T3 (13%) without interlobar P3, whereas in squamous cell carcinoma, the survival rate for interlobar P3 was between the rates for T1 (88%) and T2 (54%) without interlobar P3.
Conclusion
Tumors with interlobar P3 should be classified as T2 only in squamous cell carcinoma.
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Additional information
This study was presented at the 10th World Conference of the International Association for the Study of Lung Cancer, held in Vancouver, Canada, August 10–14, 2003
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Nonaka, M., Kataoka, D., Yamamoto, S. et al. Outcome Following Surgery for Primary Lung Cancer with Interlobar Pleural Invasion. Surg Today 35, 22–27 (2005). https://doi.org/10.1007/s00595-004-2894-2
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DOI: https://doi.org/10.1007/s00595-004-2894-2