Comparison of serum fructosamine vs glycohemoglobin as measures of glycemic control in a large diabetic population

Abstract

In diabetic patients, measurement of glycohemoglobin (HbA_1c) is widely accepted as the standard method for determining long-term glycemic control. Another test, the serum fructosamine test, has been suggested as a less costly alternative. To compare these two tests, we evaluated how well each correlated with fasting blood glucose and how well each could predict the degree of glycemic control perceived by treating physicians. Among 222 diabetic subjects, fructosamine (r=0.74) and fructosamine corrected for serum albumin (c-fructosamine) (r=0.79) correlated better with fasting blood glucose than did HbA_1c (r=0.68) (P<0.05). Among 450 diabetic subjects, fructosamine, c-fructosamine, and HbA_1c showed similar error rates (23%–26%) when discriminating between subjects who had either poor vs not-poor control or poor-to-fair versus good-to-excellent control. However, receiver operating characteristic curves for these tests indicated that HbA_1c was the best discriminator because it showed a 9% to 10% greater area under the curve (P<0.05).