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Searching peripheral blood mononuclear cells of children with viral respiratory tract infections preceding islet autoimmunity for viruses by high-throughput sequencing

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Abbreviations

IFN:

Interferon

PBMCs:

Peripheral blood mononuclear cells

GAD65:

Glutamic acid decarboxylase 65-kDa Isoform

IA-2:

Insulinoma-associated protein 2

ZnT8:

Zinc transporter 8

References

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Acknowledgements

We wish to thank Sandra Hummel for coordinating the BABYDIET study, Annette Knopf for sample collection, Manja Jolink for data management, Boyhun Lee for bioinformatics support and Gregory J. Keough for project management. A part of this work has been performed as PhD thesis work (MH) at the Technical University of Munich.

Funding

This study was supported by Juvenile Diabetes Research Fund (JDRF-No 17-2012-16, JDRF-No 9-2011-253, FDRF-No 2-SRA-2015-13-Q-R), by Wellcome Trust (WT061858/091157), by grants from the German Federal Ministry of Education and Research (BMBF) to the German Center for Diabetes Research (DZD e.V.) and by iMed—the Helmholtz Initiative on Personalized Medicine. MH was supported by the Helmholtz Graduate School Environmental Health HELENA Lab Exchange Grant.

Authors’ contribution

MH, AO, and RCF acquired the data. MH, KJ, EB, AGZ, and TB analyzed the data. MH, EB, AGZ, and TB wrote the manuscript. MH, CW, EB, AGZ, and TB designed the study. All authors revised and approved the final version of the manuscript. AGZ is responsible for the integrity of the work as a whole.

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Authors and Affiliations

  1. Institute of Diabetes Research, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany

    Markus Hippich, Christiane Winkler & Anette-Gabriele Ziegler

  2. Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA

    Alexandra Oleynik, Komal Jain & Thomas Briese

  3. Forschergruppe Diabetes e.V., at Helmholtz Zentrum München, German Research Center for Environmental, Munich, Germany

    Christiane Winkler & Anette-Gabriele Ziegler

  4. JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK

    Ricardo C. Ferreira

  5. DFG Center for Regenerative Therapies Dresden, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany

    Ezio Bonifacio

  6. Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD), Technische Universität Dresden, Dresden, Germany

    Ezio Bonifacio

  7. Forschergruppe Diabetes, at Klinikum rechts der Isar, Technische Universität München, Munich, Germany

    Anette-Gabriele Ziegler

  8. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA

    Thomas Briese

Authors
  1. Markus Hippich
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  2. Alexandra Oleynik
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  3. Komal Jain
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  4. Christiane Winkler
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  5. Ricardo C. Ferreira
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  6. Ezio Bonifacio
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  7. Anette-Gabriele Ziegler
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  8. Thomas Briese
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Corresponding author

Correspondence to Anette-Gabriele Ziegler.

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Conflict of interest

The authors declare that they have no competing interests.

Ethical standard

The BABYDIET study was approved by the local Institutional Review Board (No. 329/00) and performed in accordance with ethical standards.

Informed consent

Written informed consent was obtained prior to study inclusion.

Additional information

Managed by Massimo Federici.

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Supplementary material 1 (DOC 138 kb)

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Cite this article

Hippich, M., Oleynik, A., Jain, K. et al. Searching peripheral blood mononuclear cells of children with viral respiratory tract infections preceding islet autoimmunity for viruses by high-throughput sequencing. Acta Diabetol 55, 881–884 (2018). https://doi.org/10.1007/s00592-018-1138-7

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  • DOI: https://doi.org/10.1007/s00592-018-1138-7

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