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Left ventricular diastolic function in diabetes mellitus type 2 patients: correlation with heart rate and its variability

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Abstract

Aims

To assess the prevalence of left ventricular diastolic dysfunction in a population of patients with type 2 diabetes mellitus; to determine correlation of diastolic dysfunction with heart rate and its variability.

Methods

The study included 202 patients with type 2 diabetes mellitus. Echocardiography was performed with special reference to diastolic function, and heart rate variability was analysed using standard deviation of normal RR intervals, root mean square of successive differences and percentage of successive R–R intervals greater than 50 ms (pNN 50 %) in a 24-h electrocardiogram recording.

Results

Diastolic dysfunction is present in 79 % of type 2 diabetes mellitus patients: grade 1 in 52 %, grade 2 in 26 % and grade 3 in 1 % of patients. The subjects with grade 1 diastolic dysfunction had a statistically significantly higher heart rate variability compared with those with grade 2 diastolic dysfunction (LSD, post hoc test, p = 0.001). In the group with diastolic dysfunction, grade 2 reduced heart rate variability was recorded in 83 % of patients (37 and 7 % for grade 1 and normal diastolic function). An increase in the severity of diastolic dysfunction was associated with decreased heart rate variability and increased heart rate.

Conclusion

Progression of diastolic dysfunction is associated with a significantly greater prevalence of reduced heart rate variability, which is accompanied by increased heart rate.

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Acknowledgments

This study was elaborated within the grant of the European Regional Development Fund—Project FNUSA-ICRC (No. CZ.1.05/1.1.00/02.0123).

Conflict of interest

Jasna Cerkez Habek, Nenad Lakusic, Peter Kruzliak, Jozica Sikic, Darija Mahovic and Luka Vrbanic declare that they have no conflict of interest.

Human and Animal Rights disclosure

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008.

Informed consent disclosure

Informed consent was obtained from all patients for being included in the study.

Author information

Authors and Affiliations

  1. Department of Cardiology, Croatian Catholic University, University Hospital Sveti Duh, Zagreb, Croatia

    Jasna Cerkez Habek, Jozica Sikic & Luka Vrbanic

  2. Department of Cardiology, Special Hospital for Medical Rehabilitation, School of Medicine Osijek, Krapinske Toplice, Croatia

    Nenad Lakusic

  3. Department of Cardiovascular Diseases, International Clinical Research Center, St. Anne’s University Hospital and Masaryk University, Pekarska 53, 656 91, Brno, Czech Republic

    Peter Kruzliak

  4. Department of Neurology, University Hospital Center Zagreb, Zagreb, Croatia

    Darija Mahovic

Authors
  1. Jasna Cerkez Habek
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  2. Nenad Lakusic
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  3. Peter Kruzliak
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  4. Jozica Sikic
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  5. Darija Mahovic
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  6. Luka Vrbanic
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Corresponding author

Correspondence to Peter Kruzliak.

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Managed by Antonio Secchi.

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Habek, J.C., Lakusic, N., Kruzliak, P. et al. Left ventricular diastolic function in diabetes mellitus type 2 patients: correlation with heart rate and its variability. Acta Diabetol 51, 999–1005 (2014). https://doi.org/10.1007/s00592-014-0658-z

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  • DOI: https://doi.org/10.1007/s00592-014-0658-z

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