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Impaired baroreflex sensitivity in subjects with impaired glucose tolerance, but not isolated impaired fasting glucose

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Abstract

Impaired baroreflex sensitivity (BRS) is associated with adverse cardiovascular outcomes. There are currently no studies on BRS changes in subjects with different glycemic statuses, including normal glucose tolerance (NGT), isolated impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and newly diagnosed diabetes (NDD). The aim of this study was to investigate the effects of NDD, IGT and isolated IFG on BRS, based on a community-based data. A total of 768 subjects were classified as NGT (n = 498), isolated IFG (n = 61), IGT (n = 126) and NDD (n = 83). Spontaneous BRS was determined by the spectral α coefficient method, i.e., the square root of the ratio between the power of the RR interval and the power of systolic blood pressure in the LF frequency region (0.04–0.15 Hz) after the subjects had rested in a supine position for 5 min. Valsalva ratio was calculated as the longest RR interval after release of the Valsalva maneuver, divided by the shortest RR interval during the maneuver. As compared with NGT subjects, NDD (p = 0.039) and IGT (p = 0.041) subjects had a reduced spontaneous BRS in multivariate analysis based on analysis of covariance. NDD subjects exhibited a lower Valsalva ratio than NGT subjects (p = 0.043). However, there were no significant differences in spontaneous BRS and Valsalva ratio between subjects with isolated IFG and NGT. In conclusion, NDD and IGT subjects had an impaired BRS as compared to NGT subjects. However, reduced BRS was not apparent in subjects with isolated IFG.

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Acknowledgments

This study was supported by grants from National Cheng Kung University Hospital (NCKUH 910072) and the National Science Council, Taiwan, R.O.C. (NSC 92-2314-B-006-117).

Conflict of interest

None.

Human and Animal Rights

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008.

Informed consent

The Institutional Review Board of National Cheng Kung University Hospital approved the study and waived the need for informed consent (IRB approval number B-ER-102-060).

Author information

Authors and Affiliations

  1. Department of Family Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC

    Jin-Shang Wu, Feng-Hwa Lu, Yi-Ching Yang & Chih-Jen Chang

  2. Department of Family Medicine, National Cheng Kung University Hospital, 138, Sheng Li Road, Tainan, 70403, Taiwan, ROC

    Jin-Shang Wu, Feng-Hwa Lu, Yi-Ching Yang, Ying-Hsiang Huang & Chih-Jen Chang

  3. Department of Information and Communication, Kun Shan University, Tainan, Taiwan, ROC

    Shei-Hsi Chang

  4. Institute of Biomedical Engineering, National Cheng Kung University, Tainan, Taiwan, ROC

    Jia-Jin Jason Chen

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  1. Jin-Shang Wu
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Correspondence to Chih-Jen Chang.

Additional information

Communicated by Massimo Federici.

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Wu, JS., Lu, FH., Yang, YC. et al. Impaired baroreflex sensitivity in subjects with impaired glucose tolerance, but not isolated impaired fasting glucose. Acta Diabetol 51, 535–541 (2014). https://doi.org/10.1007/s00592-013-0548-9

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  • DOI: https://doi.org/10.1007/s00592-013-0548-9

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