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Soluble interleukin-2 receptor alpha in preclinical type 1 diabetes

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References

  1. Malek TR, Bayer AL (2004) Tolerance, not immunity, crucially depends on IL-2. Nat Rev Immunol 4:665–674

    Article  CAS  PubMed  Google Scholar 

  2. Maier LM, Anderson DE, Severson CA et al (2009) Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses. J Immunol 182:1541–1547

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  3. Maier LM, Lowe CE, Cooper J et al (2009) IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet 5:e1000322

    Article  PubMed Central  PubMed  Google Scholar 

  4. Lowe CE, Cooper JD, Brusko T et al (2007) Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nat Genet 39:1074–1082

    Article  CAS  PubMed  Google Scholar 

  5. Ziegler AG, Bonifacio B, BABYDIAB-BABYDIET Study Group (2012) Age-related islet autoantibody incidence in offspring of patients with type 1 diabetes. Diabetologia 55:1937–1943

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

The authors thank A. Knopff, A. Wosch, V. Dietrich, C. Ried, C. Matzke, and M. Scholz for expert technical assistance, and M. Bunk, S. Hummel, M. Krasmann, and A. Huppert for clinical assistance. We also thank all participants of the BABYDIAB, BABYDIET, and Munich family studies. This study was supported in part by grants from the Juvenile Diabetes Research Foundation (JDRF 17-2012-16), and from the German Federal Ministry of Education and Research (BMBF) to the Competence Network for Diabetes mellitus (FKZ 01GI0805).

Conflict of interest

None.

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Authors and Affiliations

  1. Institute of Diabetes Research, Helmholtz Zentrum München, Ingolstaedter Landstr. 1, 85764, Neuherberg, Germany

    Stephanie Krause, Andreas Beyerlein, Christiane Winkler, Christiane Kayser, Ramona Puff, Anette-Gabriele Ziegler & Peter Achenbach

  2. Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Munich, Germany

    Stephanie Krause, Andreas Beyerlein, Christiane Winkler, Christiane Kayser, Ramona Puff, Anette-Gabriele Ziegler & Peter Achenbach

  3. Forschergruppe Diabetes e.V, Neuherberg, Germany

    Anita Gavrisan, Anette-Gabriele Ziegler & Peter Achenbach

  4. Center for Regenerative Therapies, Dresden University of Technology, Dresden, Germany

    Ezio Bonifacio

  5. Paul Langerhans Institute Dresden, Dresden University of Technology, Dresden, Germany

    Ezio Bonifacio

Authors
  1. Stephanie Krause
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  2. Andreas Beyerlein
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  3. Christiane Winkler
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  4. Anita Gavrisan
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  5. Christiane Kayser
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  6. Ramona Puff
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  7. Ezio Bonifacio
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  8. Anette-Gabriele Ziegler
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  9. Peter Achenbach
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Corresponding author

Correspondence to Anette-Gabriele Ziegler.

Additional information

Communicated by Massimo Porta.

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Supplementary material 1 (DOC 45 kb)

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Krause, S., Beyerlein, A., Winkler, C. et al. Soluble interleukin-2 receptor alpha in preclinical type 1 diabetes. Acta Diabetol 51, 517–518 (2014). https://doi.org/10.1007/s00592-013-0512-8

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  • DOI: https://doi.org/10.1007/s00592-013-0512-8

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