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The potential role of glutamate in the current diabetes epidemic

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Abstract

In the present article, we propose the perspective that abnormal glutamate homeostasis might contribute to diabetes pathogenesis. Previous reports and our recent data indicate that chronically high extracellular glutamate levels exert direct and indirect effects that might participate in the progressive loss of β-cells occurring in both T1D and T2D. In addition, abnormal glutamate homeostasis may impact all the three accelerators of the “accelerator hypothesis” and could partially explain the rising frequency of T1D and T2D.

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Acknowledgments

This work was supported by University Research Program 2008 (to CP) and National Institutes of Health Grant RO1 DK080148 (to FF). AMD, CP, and FF and Eliana Sara di Cairano (ESDC) are inventors in a Patent Cooperation Treaty application (PCT/EP09/08256, US2011/0244486A1).

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Authors and Affiliations

  1. Diabetes and Endocrinology Unit, Department of Internal Medicine, San Raffaele Scientific Institute, 20132, Milan, Italy

    Alberto M. Davalli

  2. Department of Molecular Science Applied to Biosystems, Universita` degli Studi di Milano, 20134, Milan, Italy

    Carla Perego

  3. Diabetes Division, Department of Medicine, University of Texas Health Science Center, San Antonio, TX, 78229, USA

    Alberto M. Davalli & Franco B. Folli

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  1. Alberto M. Davalli
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  2. Carla Perego
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  3. Franco B. Folli
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Correspondence to Alberto M. Davalli.

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Davalli, A.M., Perego, C. & Folli, F.B. The potential role of glutamate in the current diabetes epidemic. Acta Diabetol 49, 167–183 (2012). https://doi.org/10.1007/s00592-011-0364-z

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