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Influence of iron metabolism indices on glycated haemoglobin but not glycated albumin levels in premenopausal women

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Abstract

We have recently shown that in premenopausal women without anaemia, glycated haemoglobin (HbA1C) is inversely associated with mean corpuscular haemoglobin (MCH). Based on the hypothesis that iron deficient state (IDS) due to menstruation may influence erythrocyte metabolism and thereby HbA1C levels, we examined the relation of iron metabolism indices with HbA1C in premenopausal women. HbA1C, serum glycated albumin (GA) and iron metabolism indices were determined in 104 premenopausal women with normal glucose tolerance. Among them, 17 were diagnosed with iron deficiency anaemia (IDA) and 30 with IDS. The other 57 subjects were diagnosed with normal iron state (NIS). HbA1C levels showed significant inverse association with serum iron, serum transferrin saturation and serum ferritin in 104 study participants. Multivariate regression analysis identified serum ferritin as negatively associated with HbA1C. These were also observed in 87 premenopausal women without IDA. HbA1C levels in IDA subjects and in IDS subjects were higher than it in NIS subjects, while GA levels were not different among the three groups of subjects. In conclusions, iron metabolism indices influence HbA1C levels, but not serum GA levels, in premenopausal women.

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Abbreviations

HbA1C :

Glycated haemoglobin

GA:

Glycated albumin

IDA:

Iron deficiency anaemia

IDS:

Iron deficiency state

NIS:

Normal iron state

MCH:

Mean corpuscular haemoglobin

MCV:

Mean corpuscular volume

FPG:

Fasting plasma glucose

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Authors and Affiliations

  1. Department of Internal Medicine, Kinki Central Hospital, Kuruma-zuka 3-1, Itami, Hyogo, 664-8533, Japan

    Masafumi Koga, Hiroshi Saito & Mikio Mukai

  2. Department of Clinical Laboratory, Kinki Central Hospital, Itami, Japan

    Soeko Matsumoto

  3. Department of Medicine, Nissay Hospital, Osaka, Japan

    Soji Kasayama

Authors
  1. Masafumi Koga
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  2. Hiroshi Saito
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  3. Mikio Mukai
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  4. Soeko Matsumoto
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  5. Soji Kasayama
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Correspondence to Masafumi Koga.

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Koga, M., Saito, H., Mukai, M. et al. Influence of iron metabolism indices on glycated haemoglobin but not glycated albumin levels in premenopausal women. Acta Diabetol 47 (Suppl 1), 65–69 (2010). https://doi.org/10.1007/s00592-009-0123-6

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  • DOI: https://doi.org/10.1007/s00592-009-0123-6

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