Abstract
Background
The prognosis of patients with metastatic, recurrent, and/or unresectable osteosarcoma is poor. Aggressive local and medical treatments are available for palliation. Palliative treatments include isolated limb perfusion, radiation therapy, embolization, chemoembolization, thermal ablation, and cryoablation. Their aim is pain relief and tumor size reduction with minimum complications.
Materials and methods
We present 19 patients with metastatic, recurrent, and/or unresectable osteosarcoma of the pelvis and lower lumbar spine treated with palliative selective embolization using N-2-butyl cyanoacrylate. All patients had chemotherapy. At the time of embolization, they experienced severe pain refractory to analgesics. Diagnostic angiography was performed pre-embolization to determine the vascular mapping and hemodynamic status of the tumor. Post-embolization angiography was done to evaluate for complete occlusion of the pathological vessels. Mean follow-up was 18 months. Local pain, tumor necrosis and size, and complications were recorded.
Results
In all patients, pre-embolization angiography showed hypervascularity of the tumor from extensive neovascularization. Five patients had repeat embolization. All patients experienced pain relief at a mean of 3 days post-embolization. No patient had recurrent pain with the intensity of that before embolization. Variable tumor necrosis was observed in follow-up imaging, and reduction in tumor size was minimum. All patients experienced pain at the site of embolization, which resolved completely 1–5 days after embolization. Four patients with pelvic osteosarcomas experienced paraesthesias at the distribution of the sciatic nerve.
Conclusion
Selective arterial embolization is a useful local palliative treatment for patients with advanced osteosarcoma for pain relief.
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References
Wittig JC, Bickels J, Priebat D, Jelinek J, Kellar-Graney K, Shmookler B, Malawer MM (2002) Osteosarcoma: a multidisciplinary approach to diagnosis and treatment. Am Fam Physician 65(6):1123–1132
Bacci G, Ferrari S, Mercuri M, Longhi A, Capanna R, Tienghi A, Brach del Prever A, Comandone A, Cesari M, Bernini G, Picci P (1998) Neoadjuvant chemotherapy for extremity osteosarcoma–preliminary results of the Rizzoli’s 4th study. Acta Oncol 37(1):41–48
Longhi A, Errani C, De Paolis M, Mercuri M, Bacci G (2006) Primary bone osteosarcoma in the pediatric age: state of the art. Cancer Treat Rev 32(6):423–436
Errani C, Longhi A, Rossi G, Rimondi E, Biazzo A, Toscano A, Alì N, Ruggieri P, Alberghini M, Picci P, Bacci G, Mercuri M (2011) Palliative therapy for osteosarcoma. Expert Rev Anticancer Ther 11(2):217–227
Bacci G, Briccoli A, Longhi A, Ferrari S, Mercuri M, Faggioli F, Versari M, Picci P (2005) Treatment and outcome of recurrent osteosarcoma: experience at Rizzoli in 235 patients initially treated with neoadjuvant chemotherapy. Acta Oncol 44(7):748–755
Jaffe N, Bruland ØS, Bielack SS (2009) Pediatric and adolescent osteosarcoma. Springer, NY, USA
Kempf-Bielack B, Bielack SS, Jürgens H, Branscheid D, Berdel WE, Exner GU, Göbel U, Helmke K, Jundt G, Kabisch H, Kevric M, Klingebiel T, Kotz R, Maas R, Schwarz R, Semik M, Treuner J, Zoubek A, Winkler K (2005) Osteosarcoma relapse after combined modality therapy: an analysis of unselected patients in the Cooperative Osteosarcoma Study Group (COSS). J Clin Oncol 23(3):559–568
Grignani G, Palmerini E, Dileo P, Asaftei SD, D’Ambrosio L, Pignochino Y, Mercuri M, Picci P, Fagioli F, Casali PG, Ferrari S, Aglietta M (2011) A phase II trial of sorafenib in relapsed and unresectable high-grade osteosarcoma after failure of standard multimodal therapy: an Italian Sarcoma Group study. Ann Oncol [Epub ahead of print]
Merimsky O, Kollender Y, Inbar M, Meller I, Bickels J (2004) Palliative treatment for advanced or metastatic osteosarcoma. Isr Med Assoc J 6(1):34–38
Malawer MM, Link MP, Donaldson SS (1997) Sarcomas of bone. In: DeVita VT, Hellman Sl, Rosenber SA (eds) Cancer: principles and practice of oncology, 5th edn. Lippincott-Raven, Philadelphia, pp 1731–1752
Kawai A, Healey JH, Boland PJ, Lin PP, Huvos AG, Meyers PA (1998) Prognostic factors for patients with sarcomas of the pelvic bones. Cancer 82(5):851–859
Ta HT, Dass CR, Choong PF, Dunstan DE (2009) Osteosarcoma treatment: state of the art. Cancer Metastasis Rev 28(1–2):247–263
Mialou V, Philip T, Kalifa C, Perol D, Gentet JC, Marec-Berard P, Pacquement H, Chastagner P, Defaschelles AS, Hartmann O (2005) Metastatic osteosarcoma at diagnosis: prognostic factors and long-term outcome–the French pediatric experience. Cancer 104(5):1100–1109
Daw NC, Billups CA, Rodriguez-Galindo C, McCarville MB, Rao BN, Cain AM, Jenkins JJ, Neel MD, Meyer WH (2006) Metastatic osteosarcoma. Cancer 106(2):403–412
Bacci G, Rocca M, Salone M, Balladelli A, Ferrari S, Palmerini E, Forni C, Briccoli A (2008) High grade osteosarcoma of the extremities with lung metastases at presentation: treatment with neoadjuvant chemotherapy and simultaneous resection of primary and metastatic lesions. J Surg Oncol 98(6):415–420
Federman N, Bernthal N, Eilber FC, Tap WD (2009) The multidisciplinary management of osteosarcoma. Curr Treat Options Oncol 10(1–2):82–93
Bacci G, Mercuri M, Briccoli A, Ferrari S, Bertoni F, Donati D, Monti C, Zanoni A, Forni C, Manfrini M (1997) Osteogenic sarcoma of the extremity with detectable lung metastases at presentation. Results of treatment of 23 patients with chemotherapy followed by simultaneous resection of primary and metastatic lesions. Cancer 79(2):245–254
Mavrogenis AF, Rossi G, Palmerini E, Errani C, Rimondi E, Ruggieri P, Soucacos PN, Papagelopoulos PJ (2012) Palliative treatments for advanced osteosarcoma. J BUON 17(3):436–445
Mavrogenis AF, Rossi G, Altimari G, Calabrò T, Angelini A, Palmerini E, Rimondi E, Ruggieri P (2012) Palliative embolisation for advanced bone sarcomas. Radiol Med Aug 8
Ferrari S, Briccoli A, Mercuri M, Bertoni F, Picci P, Tienghi A, Del Prever AB, Fagioli F, Comandone A, Bacci G (2003) Postrelapse survival in osteosarcoma of the extremities: prognostic factors for long-term survival. J Clin Oncol 21(4):710–715
Malawer MM, Buch RG, Thompson WE, Sugarbaker PH (1991) Major amputations done with palliative intent in the treatment of local bony complications associated with advanced cancer. J Surg Oncol 47(2):121–130
Merimsky O, Kollender Y, Inbar M, Chaitchik S, Meller I (1997) Palliative major amputation and quality of life in cancer patients. Acta Oncol 36(2):151–157
Rossi G, Mavrogenis AF, Rimondi E, Ciccarese F, Tranfaglia C, Angelelli B, Fiorentini G, Bartalena T, Errani C, Ruggieri P, Mercuri M (2011) Selective arterial embolisation for bone tumours: experience of 454 cases. Radiol Med 116(5):793–808
Krauel L, Albert A, Mora J, Sola T, Cruz O, Mortera C, Ribó JM (2009) Use of angioembolization as an effective technique for the management of pediatric solid tumors. J Pediatr Surg 44(9):1848–1855
Hansen ME, Kadir S (1990) Elective and emergency embolotherapy in children and adolescents. Efficacy and safety. Radiologe 30(7):331–336
Zhang HJ, Yang JJ, Lu JP, Lai CJ, Sheng J, Li YX, Hao Q, Zhang SM, Gupta S (2009) Use of intra-arterial chemotherapy and embolization before limb salvage surgery for osteosarcoma of the lower extremity. Cardiovasc Intervent Radiol 32(4):672–678
Chu JP, Chen W, Li JP, Zhuang WQ, Huang YH, Huang ZM, Yang JY (2007) Clinicopathologic features and results of transcatheter arterial chemoembolization for osteosarcoma. Cardiovasc Intervent Radiol 30(2):201–206
Chuang VP, Soo CS, Wallace S, Benjamin RS (1981) Arterial occlusion: management of giant cell tumor and aneurysmal bone cyst. AJR Am J Roentgenol 136(6):1127–1130
Chuang VP (1984) Angiographic contributions to the management of advanced cancer. AJR Am J Roentgenol 142(2):385–388
Gottfried ON, Schloesser PE, Schmidt MH, Stevens EA (2004) Embolization of metastatic spinal tumors. Neurosurg Clin North Am 15(4):391–399
Owen RJ (2008) Embolization of musculoskeletal tumors. Radiol Clin North Am 46(3):535–543
Mavrogenis AF, Rossi G, Rimondi E, Papagelopoulos PJ, Ruggieri P (2011) Embolization of bone tumors. Orthopedics 34(4):303–310
Börüban S, Sancak T, Yildiz Y, Sağlik Y (2007) Embolization of benign and malignant bone and soft tissue tumors of the extremities. Diagn Interv Radiol 13(3):164–171
Breslau J, Eskridge JM (1995) Preoperative embolization of spinal tumors. J Vasc Interv Radiol 6(6):871–875
Cullen JW, Jamroz BA, Stevens SL, Madsen W, Hinshaw I, Wilkins RM, Cullen P, Camozzi AB, Fink K, Peck SD, Kelly CM (2005) The value of serial arteriography in osteosarcoma: delivery of chemotherapy, determination of therapy duration, and prediction of necrosis. J Vasc Interv Radiol 16(8):1107–1119
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Mavrogenis, A.F., Rossi, G., Rimondi, E. et al. Palliative embolization for osteosarcoma. Eur J Orthop Surg Traumatol 24, 1351–1356 (2014). https://doi.org/10.1007/s00590-013-1312-0
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DOI: https://doi.org/10.1007/s00590-013-1312-0